Development of Carnivac-Cov vaccine against coronavirus infection (COVID-19) in carnivores by T. S. Galkina, A. A. Nesterov, A. V. Borisov, I. A. Chvala, A. V. Kononov

“…More than 330 animals (fur animals, cats, dogs) were involved in the preclinical and clinical trials. The trials have demonstrated that the vaccine is safe for target animals. …”
Get full text

Enteral L-Arginine and Glutamine Supplementation for Prevention of NEC in Preterm Neonates by M. S. El-Shimi, H. A. Awad, M. A. Abdelwahed, M. H. Mohamed, S. M. Khafagy, G. Saleh

“…This work is registered in ClinicalTrials.gov (ClinicalTrials.gov Identifier: NCT01263041).…”
Get full text

Efficacy and Acceptability of Orthokeratology for Slowing Myopic Progression in Children: A Systematic Review and Meta-Analysis by Daizong Wen, Jinhai Huang, Hao Chen, Fangjun Bao, Giacomo Savini, Antonio Calossi, Haisi Chen, Xuexi Li, Qinmei Wang

“…A systematic literature retrieval was conducted in MEDLINE, EMBASE, Cochrane Library, World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov. …”
Get full text

DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis by Qixian Wang, Min Long, Hua Qu, Rufei Shen, Rui Zhang, Jing Xu, Xin Xiong, Hui Wang, Hongting Zheng

“…Further optimized clinical trials are needed.…”
Get full text

MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

“…Immunotherapy has been developed and underwent clinical trials, but displayed limited therapeutic benefit. …”
Get full text

Exploring the Potential of SGLT-2 Inhibitors in Cancer Treatment: Mechanisms, Preclinical Findings, and Clinical Implications by Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak

“…However, more extensive clinical trials are required to validate their effectiveness, optimize treatment regimens, and better understand their safety profiles in cancer patients. …”
Get full text

Photodynamic therapy for the precise treatment of localized prostate cancer by Youcheng Xu, Qinyuan Tan, Chong Sun, Yuefeng Jia, Shengxian Li, Xuecheng Yang

“…We also reviewed the results of a few photosensitizers in these clinical trials. However, a few limitations and challenges regarding PDT for prostate cancer still exist. …”
Get full text

Responsive afatinib treatment in high-grade salivary gland ductal carcinoma and NSCLC with uncommon EGFR mutations: Treatment outcomes by Sivakamavalli Jeyachandran

“…Preclinical studies demonstrate its effectiveness in inhibiting tumor growth and inducing apoptosis in EGFR-amplified cell lines. Clinical trials confirm significant tumor responses and improved progression-free survival with afatinib treatment. …”
Get full text

Evaluation of the efficacy of low concentration fluoride gel using custom trays to prevent radiation-related dental caries in patients with head and neck cancer: protocol for a ran... by Yumiko Kawashita, Masahiro Umeda, Toshiyuki Saito, Sakiko Soutome, Souichi Yanamoto, Maho Murata, Masako Yoshimatsu, Madoka Funahara

“…Target accrual is 80 patients with a two-sided type I error rate of 5% and 80% power to detect 80% risk reduction.Ethics and dissemination This study was approved by the Clinical Research Review Board in Nagasaki University The protocol of this study was registered at Japan Registry of Clinical Trials (jRCT) and University hospital Medical Information Network Clinical Trials Registry (UMIN). …”
Get full text

Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy by Irina Arutyunyan, Andrey Elchaninov, Andrey Makarov, Timur Fatkhudinov

“…A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria.…”
Get full text

Early disease detection expert system development: primary machining software applications and dependences by A. S. Serobabov, E. V. Chebanenko, L. A. Denisova, T. S. Krolevets

“…The article observes descriptive statistics tools for the biomedical information processing, clinical trials data on the nonalcoholic fatty liver disease (NAFLD). …”
Get full text

A conceptual model for advanced/metastatic gastric or gastroesophageal junction cancer: a review of qualitative studies and results from patient interviews by France Ginchereau Sowell, Thom de Milliano, Keri J. S. Brady, Ginamarie Foglia, Medha Sasane, Samira Bensfia, Matthew Reaney

“…Interviews also help understand patients’ perspectives on clinical trials.…”
Get full text

Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder by Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman

“…However, urgency has been understudied in clinical trials, potentially owing to inherent difficulties in its assessment. …”
Get full text

The need for evidence-based, outcome-focused medical imaging research for cancer management by Jiazheng Wang, Richard L. Hesketh, John C. Gore, Kevin M. Brindle

“…We argue there remain compelling needs for better designs of clinical trials, imaging protocol standards, quantification methods, efficient translation pathways and patient engagement.…”
Get full text

Maintenance Therapy for Inflammatory Bowel Disease: What Really Works by Lloyd R Sutherland

“…Therapies that have been shown in randomized, controlled, double-blind clinical trials to either lengthen the time of remission or improve the odds of staying in remission during a set time interval are required.…”
Get full text

Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Open Access Journal of Clinical Trials. 2018;Volume 10:19-28. doi:10.2147/oajct.s156054; Mezher M. …”
Get full text

Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad by Laura Bennet, Joanne O. Davidson, Miriam Koome, Alistair Jan Gunn

“…Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. …”
Get full text

The Pros and Cons of Dental Laser Therapy in Conservative Dentistry and Endodontics—A Systematic Review by Priyanka Sarangi, Shradha Suman, Sukanta Kumar Satapathy, Rinki Meher, Abhisek Das, Divya M Pradeep

“…The search engines, such as PubMed, Cochrane, and Scopus, were utilized to locate human clinical trials pertaining to the application of lasers in endodontic therapy. …”
Get full text

Progress in personalized immunotherapy for patients with brain metastasis by Lalit Patel, Nikola Kolundzic, Malak Abedalthagafi

“…This review explores the immune landscape of brain metastases, current therapies, clinical trials, and the need for personalized, biomarker-driven approaches to optimize outcomes.…”
Get full text

Association of age, race, and ethnicity with access, response, and toxicities from CAR-T therapy in children and adults with B-cell malignancies: a review by Marco Ruella, Guido Ghilardi, Zainul S. Hasanali, Sandra P. Susanibar-Adaniya, Lena E. Winestone, Alfred L. Garfall

“…We also review the representation of age, racial, and ethnic groups in key CAR-T clinical trials. We focus on B-cell acute lymphoblastic leukemia, B-cell non-Hodgkin’s lymphoma, and multiple myeloma.…”
Get full text