A Systematic Review of Bilateral Upper Limb Training Devices for Poststroke Rehabilitation by A. (Lex) E. Q. van Delden, C. (Lieke) E. Peper, Gert Kwakkel, Peter J. Beek

“…In total, 6 mechanical and 14 robotic bilateral upper limb training devices were evaluated in terms of mechanical and electromechanical characteristics, supported movement patterns, targeted part and active involvement of the upper limb, training protocols, outcomes of clinical trials, and commercial availability. Conclusion. …”
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Outcomes of Vitrectomy in Pediatric Retinal Detachment with Proliferative Vitreoretinopathy by Robert Rejdak, Dominika Nowakowska, Katarzyna Wrona, Ryszard Maciejewski, Anselm G. Junemann, Katarzyna Nowomiejska

“…This trial is registered with ClinicalTrials.gov Identifier: NCT03208205.…”
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Environmental Enrichment Therapy for Autism: Outcomes with Increased Access by Eyal Aronoff, Robert Hillyer, Michael Leon

“…We have previously shown in two randomized clinical trials that environmental enrichment is capable of ameliorating symptoms of autism spectrum disorder (ASD), and in the present study, we determined whether this therapy could be effective under real-world circumstances. 1,002 children were given daily Sensory Enrichment Therapy, by their parents, using personalized therapy instructions given over the Internet. …”
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Efficacy of Dental Bleaching with Whitening Dentifrices: A Systematic Review by Bruno G. S. Casado, Sandra L. D. Moraes, Gleicy F. M. Souza, Catia M. F. Guerra, Juliana R. Souto-Maior, Cleidiel A. A. Lemos, Belmiro C. E. Vasconcelos, Eduardo P. Pellizzer

“…Electronic systematic searches of PubMed/MEDLINE, Scopus, and the Cochrane Library were conducted for published articles. Only randomized clinical trials in adults that compared the use of so-called whitening dentifrices to the use of nonwhitening dentifrices were selected. …”
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Comparative efficacy of minoxidil alone versus minoxidil combined with low-level laser therapy in the treatment of androgenic alopecia: a systematic review and meta-analysis by Abdulmajeed Alosaimi, Abdullah Algarni, Abdulrahman Alharbi, Abdulmalik Alotaibi, Abdullah Alomairi, Mohannad Alsurayhi, Waleed Alharbi

“…Objective This systematic review evaluates the efficacy of minoxidil alone versus minoxidil with low-level laser therapy (LLLT) for androgenic alopecia.Study design systematic review and meta-analysis.Methods An online search of PubMed, Web of Science, and MEDLINE was conducted. Randomized clinical trials comparing minoxidil monotherapy with minoxidil and LLLT combination therapy were included based on predefined criteria. …”
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Phages as potential life-saving therapeutic option in the treatment of multidrug-resistant urinary tract infections by Beata Zalewska-Piątek, Michalina Nagórka

“…PT demonstrates significant potential in treating chronic and recurrent UTIs, also including catheter-associated infection by reducing bacterial biofilms, delaying catheter blockage, and enhancing antibiotic efficacy when used in combination. Clinical trials and case studies have reported high rates of bacterial eradication and symptom improvement with minimal side effects. …”
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Opioid Therapy for Chronic Nonmalignant Pain by Russell K Portenoy

“…The few controlled clinical trials that have been performed support the safety and efficacy of opioid therapy, but have been too limited to ensure generalization to the clinical setting. …”
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Harnessing the AI/ML in Drug and Biological Products Discovery and Development: The Regulatory Perspective by Fahimeh Mirakhori, Sarfaraz K. Niazi

“…Artificial Intelligence (AI) has the disruptive potential to transform patients’ lives via innovations in pharmaceutical sciences, drug development, clinical trials, and manufacturing. However, it presents significant challenges, ethical concerns, and risks across sectors and societies. …”
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New Test for the Comparison of Survival Curves to Detect Late Differences by Ildephonse Nizeyimana, Samuel Mwalili, George Orwa

“…It has been widely exploited in clinical trials when comparing different treatments looking at their survival probabilities. …”
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A Review of Herbal Treatment for Functional Gastrointestinal Disorders and Infection by Krupavaram B, A Kishore Babu, Santhiya Manickam Pillay, Tan Ching Siang, Bama V. V. Menon, Ganesh Sritheran Paneerselvam, Long Chiau Ming, Yaser Mohammed Al-Worafi, Wen Han Chooi

“…In this article, we conducted PubMed searches using specific keywords to review clinical trials focusing on conventional and herbal treatments for dyspepsia as well as the adverse effects of non-herbal treatments. …”
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Submacular Injection of Ranibizumab as a New Surgical Treatment for Refractory Diabetic Macular Edema by Samir M. El-Baha, Ahmed M. Abdel Hadi, Mahmoud A. Abouhussein

“…The study has been registered in Contact ClinicalTrials.gov PRS Identifier: NCT03975088.…”
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The Effects of Uncomplicated Cataract Surgery on Retinal Layer Thickness by Ali Kurt, Raşit Kılıç

“…This study was registered with Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12618000763246.…”
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Effects of using wearable devices to monitoring physical activity in pulmonary rehabilitation programs for chronic respiratory diseases: A systematic review protocol. by Thaianne Rangel Agra Oliveira, Ana Tereza do Nascimento Sales Figueiredo Fernandes, Thayla Amorim Santino, Fernanda Elizabeth Pereira da Silva Menescal, Patrícia Angélica de Miranda Silva Nogueira

“…We will include baseline data from randomized clinical trials reporting the use of wearable devices for monitoring physical activity in protocols for pulmonary rehabilitation programs for chronic respiratory diseases. …”
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Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints by Jun Fukae, Yoshiharu Amasaki, Yuichiro Fujieda, Yuki Sone, Ken Katagishi, Tatsunori Horie, Tamotsu Kamishima, Tatsuya Atsumi

“…The study was registered in UMIN Clinical Trials Registry (UMIN000054321). Results A total of 156 clinical joint ultrasound images from 74 patients with RA were included. …”
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The Relationship Between the Modulation of Intestinal Microbiota and the Response to Immunotherapy in Patients with Cancer by Laura Radoš, Marin Golčić, Ivana Mikolašević

“…Fecal transplantation is a safe and realistic adjuvant option for the treatment of cancer patients with immunotherapy, but more clinical trials are necessary. Modulating the microbiota composition indeed changes the effectiveness of immunotherapy, but in the future, more human studies should be organized to precisely determine the types and procedures of microbiota modulation.…”
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An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy by Zunaira Qureshi, Murtaza Najabat Ali, Minahil Khalid

“…Treating painful symptoms in diabetic patient can be frustrating not only for the patients but also for health care workers, so additional clinical trials for novel and conventional treatments are required to devise more effective treatment for PDN with minimal side effects. …”
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The Microbiome-Gut-Brain Axis, Nutrition and Parkinson’s Disease by Jevgenija Guk, Rūta Kaladytė Lokominienė, Dalius Jatužis

“…Although epidemiological and experimental studies in animal models have shown their neuroprotective properties, their effectiveness was not confirmed in clinical trials. However, daily food intake comprises many nutrients that can interact and produce either a synergistic or antagonistic effect on the human body. …”
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Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease by Jie Zhao, Yan Bao, Ying Gao, Keliang Xie

“…Urgent and well-designed clinical trials are imperative to unravel the intricate interplay between RP-ILD and the IFN signature in MDA5-DM, and to evaluate novel therapeutic targets that promise long-term efficacy and safety.…”
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A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines by Jose Miguel Rubio-Perez, Juana Maria Morillas-Ruiz

“…It has been observed in epidemiological studies that treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) decreases the risk for developing AD. Unfortunately, clinical trials of NSAIDs in AD patients have not been very fruitful. …”
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PPAR Agonists and Cardiovascular Disease in Diabetes by Anna C. Calkin, Merlin C. Thomas

“…Many of these potentially anti-atherosclerotic effects are thought to be mediated by transrepression of nuclear factor-kB, STAT, and activator protein-1 dependent pathways. In recent clinical trials, PPAR𝛼 agonists have been shown to be effective in the primary prevention of cardiovascular events, while their cardiovascular benefit in patients with established cardiovascular disease remains equivocal. …”
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