Possible factors responsible for increased risk of tendon injuries during strength training in adult patients: systematic review by Zbigniew Wroński, Burim Gjinovci, Mario Klasic

“…Material and methods: A search was conducted in June and July 2023 in PubMed/Medline, EMBASE, Science Direct, PEDro, and Cochrane databases. Clinical trials, meta-analyses, randomized controlled trials, reviews, and systematic reviews published within the last ten years were included if they considered strength and resistance training as risk factors for tendon injuries. …”
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Acute Putrescine Supplementation with Schwann Cell Implantation Improves Sensory and Serotonergic Axon Growth and Functional Recovery in Spinal Cord Injured Rats by J. Bryan Iorgulescu, Samik P. Patel, Jack Louro, Christian M. Andrade, Andre R. Sanchez, Damien D. Pearse

“…Schwann cell (SC) transplantation exhibits significant potential for spinal cord injury (SCI) repair and its use as a therapeutic modality has now progressed to clinical trials for subacute and chronic human SCI. Although SC implants provide a receptive environment for axonal regrowth and support functional recovery in a number of experimental SCI models, axonal regeneration is largely limited to local systems and the behavioral improvements are modest without additional combinatory approaches. …”
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Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques by Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Mahesh Attimarad, Anroop B. Nair

“…This article summarizes key stabilizers, polymers, surfactants, and excipients used in NS formulations, along with ongoing clinical trials and recent patents. Furthermore, a comprehensive analysis of various methods for NS preparation is provided. …”
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Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia by Yuri Sakai Ishizaki, Masao Kikuchi, Koichi Kaikita, Shouichi Fujimoto

“…SGLT2 inhibitors have demonstrated efficacy in suppressing CKD progression in clinical trials, but their mechanisms are not fully understood. …”
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The Natural History of Pancreatic Cancer in Manitoba: A Population Based Study by Jack Martin, Brian H Weinerman

“…The poor prognosis of all individuals confirms the rationale of trying to develop better treatments for all stages of disease, and stage and pathological differentiation should be taken into account when designing clinical trials.…”
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Design and Preparing a Topical Semi-solid Formulation of a Combination of Plantago ovata seeds and Rosehip oil to Provide an Analgesic and Anti-inflammatory Medicine by Amirhossein Zamani, Aida Alipour, Mohammad M. Zarshenas, Hajar Ashrafi

“…After passing the clinical trials, the mentioned product can be effective as a product derived from herbal compounds for pain control.…”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…While there are various novel treatment strategies already underway in clinical trials, the need for further development of preclinical models of this rare but aggressive disease is paramount.…”
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GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes by María Isabel del Olmo-Garcia, Juan Francisco Merino-Torres

“…On the other hand, recent clinical trials aimed at studying cardiovascular episodes have been conducted with GLP-1 RAs. …”
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An sveir model for assessing potential impact of an imperfect anti-SARS vaccine by Abba B. Gumel, C. Connell McCluskey, James Watmough

“…Owing to the recent ongoing clinical trials ofsome candidate anti-SARS vaccines, this study aims to assess, via mathematical modelling, the potential impact of a SARS vaccine,assumed to be imperfect, in curtailing future outbreaks. …”
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Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinso... by Antonio Daniele, Francesco Panza, Antonio Greco, Giancarlo Logroscino, Davide Seripa

“…Since a high density of zolpidem binding sites is in the two main output structures of the basal ganglia which are abnormally overactive in PD (internal globus pallidus, GPi, and substantia nigra pars reticulata, SNr), it was hypothesized that in PD patients zolpidem may induce through GABAA receptors an inhibition of GPi and SNr (and, possibly, of the subthalamic nucleus also), resulting in an increased activity of motor cortical areas (such as supplementary motor area), which may give rise to improvement of motor symptoms of PD. Randomized clinical trials are needed in order to assess the efficacy, safety, and tolerability of zolpidem in treating motor symptoms of PD.…”
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The Role of Immunotherapy in Extensive Stage Small-Cell Lung Cancer: A Review of the Literature by Ioanna Tsiouprou, Athanasios Zaharias, Dionisios Spyratos

“…During the past few years, several clinical trials have evaluated the effect of addition of immunotherapy to conventional chemotherapy in patients with extensive SCLC. …”
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Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials by Changjiang Qin, Xuequn Ren, Kaiwu Xu, Zhihui Chen, Yulong He, Xinming Song

“…Preoperative radio(chemo)therapy (pR(C)T) appears to increase postoperative complications of rectal cancer resection, but clinical trials have reported conflicting results. The objective of this meta-analysis was performed to assess the effects of pR(C)T on anastomotic leak after rectal cancer resection. …”
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Finite Element Modelling Based Studies for Dental Implants: Systematic Review by Shahad Mohammed Shakir, Saja Ali Muhsin, Raad Al Marza

“…Finite element methods not only give speedy and reliable data on the patients under investigation, but they also act as essential guidance for many clinical trials. To have a better understanding of the finite element modelling method. …”
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Immunotherapy for Metastatic Melanoma with Right Atrial Involvement in a Patient with Rheumatoid Arthritis by Zachary Benson, Sarah Gordon, Patricia Nicolato, Andrew Poklepovic

“…Patients with preexisting autoimmune diseases or prior immune-related adverse events from therapy are largely excluded from clinical trials. Concerns exist that immunotherapy in these patients could worsen autoimmune disease or increase the risk of developing additional immune-related adverse events on therapy. …”
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Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…In experiment, MMSC prevented the ethanol-induced GM damage, stimulated mucin release and its redistribution on the GM surface; in clinical trials, MMSC effectively facilitated remission in duodenal ulcer.Conclusion. …”
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Acupuncture in the Treatment of a Female Patient Suffering from Chronic Schizophrenia and Sleep Disorders by Peggy Bosch, Sabina Lim, Sujung Yeo, Sook-Hyun Lee, Heike Staudte, Maurits van den Noort

“…In sum, this study showed that acupuncture might be beneficial in the treatment of sleep disorders in patients suffering from chronic schizophrenia, but future, large, randomized (placebo), controlled, clinical trials are needed in order to replicate the present preliminary findings.…”
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Long-Term Safety of Transplanting Human Bone Marrow Stromal Cells into the Extravascular Spaces of the Choroid of Rabbits by Adi Tzameret, Sapir E. Kalish, Ifat Sher, Lea Twito, Amilia Meir, Itay Levy, Shlomo Margel, Iris Moroz, Mordechai Rosner, Avraham J. Treves, Arnon Nagler, Michael Belkin, Ygal Rotenstreich

“…Assessing the safety of hBMSC treatment and graft survival in a large animal is a crucial step before initiating clinical trials. Here, we transplanted hBMSCs into the EVSC compartment of New Zealand White rabbits. …”
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A Bayesian Adaptive Design in Cancer Phase I Trials Using Dose Combinations in the Presence of a Baseline Covariate by Márcio Augusto Diniz, Sungjin Kim, Mourad Tighiouart

“…A Bayesian adaptive design for dose finding of a combination of two drugs in cancer phase I clinical trials that takes into account patients heterogeneity thought to be related to treatment susceptibility is described. …”
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Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions: What Is the Current State of Evidence? by Noémi Dahan-Oliel, Bahar Kasaai, Kathleen Montpetit, Reggie Hamdy

“…A literature search using five electronic databases identified 24 studies that met our inclusion criteria. Two randomized clinical trials were included; most studies were case studies with small sample sizes and no control group. …”
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Osteogenic Potential of Dental Mesenchymal Stem Cells in Preclinical Studies: A Systematic Review Using Modified ARRIVE and CONSORT Guidelines by Murali Ramamoorthi, Mohammed Bakkar, Jack Jordan, Simon D. Tran

“…However well-designed randomized animal trials are needed before moving into clinical trials.…”
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