Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes by Zijun Ma, Kaiqin Jin, Mengmeng Yue, Xin Chen, Jun Chen

“…Its hypoglycaemic and weight loss effects have been demonstrated in several large clinical trials, and there is also evidence that it has great potential for cardiovascular protection. …”
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Mechanisms of Inflammation in Proliferative Vitreoretinopathy: From Bench to Bedside by Stavros N. Moysidis, Aristomenis Thanos, Demetrios G. Vavvas

“…Here we review inflammatory and other mechanisms involved in the pathogenesis of PVR, we highlight important clinical trials, and we discuss how findings at the bench have the potential to be translated to the bedside.…”
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Current Situation and Consideration about Rehabilitation of Spinal Cord Injury by Anren ZHANG

“…This article reviews the epidemiology, pathophysiology and present situation of treatment for SCI, and points out that conducting epidemiological investigation, establishing unified evaluation criterion of curative effect, arranging randomized controlled clinical trials and searching for safe and effective methods are important. …”
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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor by Joshua D. Grill, Daniel Gillen

“…Abstract We consider the recent publication by Ornish and colleagues and the rigor expected for interventional clinical trials. We contend that lifestyle intervention trials should strive for the same rigor as drug trials and highlight opportunities to improve rigor in this example, particularly in design, data analysis, and publication of results for this and other lifestyle intervention studies.…”
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A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy by Jin Bian, Yan Niu, Yanli Ma, Fuhua Chen, Ning Ma

“…Immune checkpoint blockade therapy targeting the programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L 1) receptors have shown efficacy in early phase I clinical trials, with ongoing phase III clinical trials. …”
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A Systematic Overview of the Measurement Properties of the Chronic Respiratory Questionnaire by Yves Lacasse, Eric Wong, Gordon Guyatt

“…The authors examined the measurement properties of a disease-specific HRQL questionnaire, the Chronic Respiratory Questionnaire (CRQ), when used by independent investigators in clinical trials and observational studies.…”
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Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…Of central importance for clinical trials is the detection of retinal neurodegeneration in the clinical setting, and spectral domain optical coherence tomography seems the most indicated technique. …”
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Novel findings regarding treatment obesity and weight-related comorbidities – the systemic literature review by Karina Urbańska, Dariusz Popiela, Łukasz Stojak, Filip Kwiatkowski, Katarzyna Grego, Mateusz Grego, Mateusz Baczewski, Witold Czyż

“…Recent years have brought many new drugs that are very effective in obesity treatment and even more are in clinical trials. This review aims to synthesize the literature regarding new drugs and their effectiveness in treating obesity and their impact on related diseases. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…We searched for relevant papers within PubMed, EMBASE, the Cochrane Database of Systematic Reviews, and the Clinical Trials database (ClinicalTrials.gov). Two authors independently selected studies for inclusion, data extraction, and bias assessment. …”
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Psychedelics for Brain Injury: A Mini-Review by Mia Khan, Gregory T. Carter, Sunil K. Aggarwal, Julie Holland

“…Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. Recent clinical trials have begun into the use of psychedelic therapeutics for treatment of brain injury. …”
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Validation of a multiplexed immunoassay for immunological analysis of pre erythrocytic malaria vaccines by L. K. Stockdale, S. Provstgaard-Morys, D. Bellamy, D. Woods, K. Rapi, A. Bajer, B. Hollingdale, O. Muñoz, S. Malik, A. V. S. Hill, K. J. Ewer

“…Abstract The primary immunological readout for clinical trials of R21/MatrixM™ malaria vaccine, is total IgG antibody specific to the central four amino acid NANP repeat region of the circumsporozoite protein. …”
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The Effect of Locomotor Training on Gait Parameters in Pediatric Patients with Cerebral Palsy: a Systematic Review and Meta-analysis by Emilija Strazdaitė, Dovilė Kielė

“…A systematic review with meta-analysis was conducted based on the results of the PubMed (MEDLINE) and the CINAHL Ultimate (EBSCOhost) searches for randomized clinical trials. Results. Fifteen eligible randomized clinical trials involving 375 pediatric patients with cerebral palsy were included. …”
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Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening by Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu, Yujing Li

“…Clinical trials serve as the fundamental prerequisite for clinical therapy of human disease, which is primarily based on biomedical studies in animal models. …”
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DEPEND study protocol: early detection of patients with pancreatic cancer – a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as scr... by Christopher D Byrne, Sam Wilding, Paul Remi Afolabi, Declan McDonnell, Victoria Goss, Jocelyn Walters, Zaed Z Hamady

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Evaluation of the Content Validity of the COVID-19 Symptoms Daily Diary by Dine J, Guan Y, Milien M, Ervin C, Byrne DD, Brown ML, De Anda C, Norquist JM

“…This rigorous evaluation (aligned with regulatory guidance) indicates that the CSDD is fit for the purpose of supporting efficacy endpoints in planned clinical trials evaluating medications for COVID-19 treatment.Keywords: patient-reported outcome measures, COVID-19, qualitative, symptom burden…”
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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

“…Trial Registration: EU Clinical Trials Register Eudra CT: 2017-001785-14 ( https://www.clinicaltrialsregister.eu/ctr-search/trial/2017-001785-14/GB ); ISRCTN registry Identifier: ISRCTN12600919 ( https://www.isrctn.com/ISRCTN12600919 ).…”
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mRNA vaccines in the context of cancer treatment: from concept to application by Qiang Fu, Xiaoming Zhao, Jinxia Hu, Yang Jiao, Yunfei Yan, Xuchen Pan, Xin Wang, Fei Jiao

“…Additionally, we summarize preclinical studies and clinical trials to provide valuable insights into the current status of mRNA vaccines in cancer treatment. …”
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The Pathology of T Cells in Systemic Lupus Erythematosus by Anselm Mak, Nien Yee Kow

“…Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings.…”
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The methods of treatment of atrial fibrillation in patients with valvular heart disease by O.M. Grytsay, Y.V. Skybchyk, I.Y. Mokryk, E.V. Zhytyns’kiy, V.О. Kuts, О.J. Zharinov, B.M. Todurov

“…The article also presents the results of clinical trials in valvular atrial fibrillation, after surgical and complex treatment. …”
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Prostate-Specific Membrane Antigen-Based Therapeutics by Naveed H. Akhtar, Orrin Pail, Ankeeta Saran, Lauren Tyrell, Scott T. Tagawa

“…Anti-PSMA monoclonal antibody-drug conjugates have also been developed with completed and ongoing early-phase clinical trials. As PSMA is a selective antigen that is highly overexpressed in prostate cancer, anti-PSMA-based immunotherapy has also been studied and utilized in clinical trials.…”
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