Cell-Based Strategies for Meniscus Tissue Engineering by Wei Niu, Weimin Guo, Shufeng Han, Yun Zhu, Shuyun Liu, Quanyi Guo

“…Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. …”
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Mesenchymal Stem Cells as New Therapeutic Agents for the Treatment of Primary Biliary Cholangitis by Aleksandar Arsenijevic, C. Randall Harrell, Crissy Fellabaum, Vladislav Volarevic

“…In this review, we have summarized the therapeutic potential of MSCs for the treatment of these diseases, emphasizing molecular and cellular mechanisms responsible for MSC-based effects in an animal model of PBC and therapeutic potential observed in recently conducted clinical trials. We have also presented several outstanding problems including safety issues regarding unwanted differentiation of transplanted MSCs which limit their therapeutic use. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…This paper will highlight the preclinical successes and the excitement generated by phase II trials while offering alternative possibilities and new translational avenues that can be explored given the very recent disappointment in leading agents in more advanced clinical trials.…”
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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…This review will discuss experimental therapeutics that have been tested in murine ALS models, with an emphasis on those that have progressed to human clinical trials. Reasons will be considered for the frequent failure of preclinical successes to translate into positive clinical outcomes. …”
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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection by Aarti Tripathi, Shailendra Chauhan, Renu Khasa

“…Various approaches have been extensively utilized in clinical trials for antiviral development, targeting virus entry, replication, polyprotein synthesis and processing, and egress pathways exploiting virus as well as host proteins. …”
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Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease by Tianle Chen, Yuanjia Wang, Yanyuan Ma, Karen Marder, Douglas R. Langbehn

“…Accurate estimation of the AAO distribution based on CAG repeat length is important for genetic counseling and the design of clinical trials. In the Cooperative Huntington's Observational Research Trial (COHORT) study, the CAG repeat length is known for the proband participants. …”
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Novel fusion protein REA induces robust prime protection against tuberculosis in mice by Sintayehu Kebede Gurmessa, Han-Gyu Choi, Yong Woo Back, Zongyou Jiang, Thuy An Pham, Seunga Choi, Hwa-Jung Kim

“…Abstract While many novel candidates for tuberculosis vaccines are presently undergoing pre-clinical or clinical trials, none of them have been able to eliminate infection entirely. …”
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Bringing MDMA-assisted therapy for PTSD to traditional healthcare systems: tending to set and setting by Dimitri Perivoliotis, Dimitri Perivoliotis, Kayla Knopp, Kayla Knopp, Shannon Remick, Allie Kaigle, Allie Kaigle, Christopher S. Stauffer, Christopher S. Stauffer, Chandra Khalifian, Chandra Khalifian, Tamara R. Wachsman, Bettye E. Chargin, Andrew W. Bismark, Andrew W. Bismark, Al Alam, Al Alam, Leslie Morland, Leslie Morland, Leslie Morland

“…Mostly derived from our experience conducting clinical trials of MDMA-AT for PTSD in VHA, we present specific and practical suggestions for optimizing set and setting from both the participant’s and clinician’s perspective in a manner that both leverages the opportunities of such settings and adapts to their challenges. …”
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Update on Nonsurgical Lung Volume Reduction Procedures by J. Alberto Neder, Denis E. O’Donnell

“…ELVR procedures are currently available in selected Canadian research centers as part of ethically approved clinical trials. If a decision is made to offer an ELVR procedure, one-way valves are the first option in the presence of complete lobar exclusion and no significant collateral ventilation. …”
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Pharmacotherapy of Peptic Ulcer Disease by F Molina, MM Vohra, CN Williams

“…Combination therapy has not yet proved to be better than single drug therapy; however, the number of studies is still small, and more clinical trials are necessary. Resistant ulcers have demonstrated that acid is one of several etiological factors and that more research is needed to elucidate the reason(s) for refractoriness. …”
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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

“…Bridging laboratory findings with practical applications, recent clinical trials highlight the potential of optimizing liver regeneration strategies. …”
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Drugs from poisonous plants: Ethnopharmacological relevance to modern perspectives by Bhagya Lakhmi Rajbongshi, Ashis K. Mukherjee

“…This review accentuates the need for rigorous scientific investigations, prior to clinical trials to validate their traditional uses, which would reveal the pharmacological interventions that will eventually advance human health and well-being.…”
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Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy by Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding

“…Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused researchers to shift their focus to synaptic functions and increased the importance of clinically available imaging for synaptic density and the development of synapse-targeted intervention. …”
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Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside by Sidra Tabassum, Silin Wu, Chang-Hun Lee, Bosco Seong Kyu Yang, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren

“…We also evaluate various preclinical studies exploring pharmacological agents, gene therapy, and novel drug delivery systems designed to protect and restore mitochondrial function. Clinical trials and their outcomes are assessed to evaluate the translational potential of mitochondrial-targeted therapies in TBI. …”
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The Impacts of Educational Asthma Interventions in Schools: A Systematic Review of the Literature by Ana Carla Carvalho Coelho, Laís Souza Barretto Cardoso, Carolina de Souza-Machado, Adelmir Souza-Machado

“…A systematic review was conducted for controlled clinical trials investigating the effectiveness of educational asthma interventions for students, asthmatic or nonasthmatic, families, and school staff. …”
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The potential impact of a prophylactic vaccine for Ebola in Sierra Leone by Erin N. Bodine, Connor Cook, Mikayla Shorten

“…A prophylactic vaccine for ebolavirus (rVSV-ZEBOV) has been developed, and clinical trials show near-perfect efficacy. We have developed an ordinary differential equations model that simulates an EVD epidemic and takes into account (1) transmission through contact with infectious EVD individuals and deceased EVD bodies, (2) the heterogeneity of the risk of becoming infected with EVD, and (3) the increased survival rate of infected EVD patients due to greater access to trained healthcare providers. …”
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Prediction of hemolytic peptides and their hemolytic concentration by Anand Singh Rathore, Nishant Kumar, Shubham Choudhury, Naman Kumar Mehta, Gajendra P. S. Raghava

“…Abstract Peptide-based drugs often fail in clinical trials due to their toxicity or hemolytic activity against red blood cells (RBCs). …”
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Nutraceuticals and Pharmaceuticals by E. A. Poluektova, A. G. Beniashvili, R. V. Maslennikov

“…Some nutraceuticals, such as probiotics, have confirmed their effectiveness in clinical trials, while the beneficial properties of others require further elucidation.Conclusions. …”
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Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Michael P. Kahle, Gregory J. Bix

“…It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …”
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Safety and immunogenicity in humans of enterotoxigenic Escherichia coli double mutant heat-labile toxin administered intradermally by Marcela F. Pasetti, Patricia L. Milletich, Jessica A. White, Jessica Butts, Rebecca C. Brady, Michelle D. Dickey, Cassandra Ballou, Nicole Maier, Marcelo B. Sztein, Shahida Baqar, A. Louis Bourgeois, David I. Bernstein

“…Trial registration Clinical Trials NCT02531685.…”
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