Therapeutic applicability of helminths in autoimmune diseases – literature overview by Jacek Zwiernik, Tomasz Arłukowicz, Beata Zwiernik, Tomasz Matyskieła, Marta Gimeła-Dargiewicz, Agnieszka Rakowska, Beata Januszko-Giergielewicz, Ewa Rotkiewicz

“…The outcomes of clinical trials conducted both on animals and humans give reasons to assume that the modification of the human intestinal microflora may be the key to fighting against these diseases.…”
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Tecovirimat in the management of poxviruses: a narrative review of available evidence by Olalekan John Okesanya, Jerico Bautista Ogaya, Ikponmwosa Jude Ogieuhi, Mohamed Mustaf Ahmed, Bonaventure Michael Ukoaka, Ojoisimi Franca Jamgbadi, Deborah Oluwaseun Shomuyiwa, Don Lucero-Prisno Eliseo, Blessing Olawunmi Amisu, Olakulehin Adebusuyi, William K. Chung, Emery Manirambona, Nimat Bola Idris, Janet Alexis A. De los Santos

“…Methodology A literature search was conducted using keywords from Scopus and ClinicalTrials.gov. English studies from 2018 to 2024 were included. …”
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The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients by Faisal A. Alzahrani, Islam M. Saadeldin, Abrar Ahmad, Dipak Kumar, Esam I. Azhar, Arif Jamal Siddiqui, Bassem Kurdi, Abdulrahim Sajini, Abdulmajeed F. Alrefaei, Sadaf Jahan

“…This review highlights the available clinical trials that support the therapeutic potential of MSCs or MSCs-Exo in severely affected COVID-19 patients.…”
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Defining Optimal Aerobic Exercise Parameters to Affect Complex Motor and Cognitive Outcomes after Stroke: A Systematic Review and Synthesis by S. M. Mahmudul Hasan, Samantha N. Rancourt, Mark W. Austin, Michelle Ploughman

“…Using predefined criteria, we included clinical trials of stroke of any type or duration and animal studies employing any established models of stroke. …”
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Brain Metastases Research 1990–2010: Pattern of Citation and Systematic Review of Highly Cited Articles by Carsten Nieder, Anca L. Grosu, Minesh P. Mehta

“…Among the 10 most cited articles, 7 reported on randomized clinical trials. Nine covered surgical or radiosurgical approaches and the remaining one a widely adopted prognostic score. …”
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Randomised controlled trial to investigate the effectiveness of local oestrogen treatment in postmenopausal women undergoing pelvic organ prolapse surgery (LOTUS): a pilot study to... by Jane Daniels, Lee Middleton, Tina Sara Verghese, Versha Cheed, Lisa Leighton, Pallavi Manish Latthe

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‘Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus’ by Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Daniel Fabian, Claudia Wild

“…Information on clinical trials, university spinouts and public funding for SMEs was then gathered from various sources. …”
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Inhaled Corticosteroid Therapy Does Not Control Asthma by Robert L Cowie, Margot F Underwood, Stephen K Field

“…BACKGROUND: Randomized clinical trials demonstrate efficacy and show that inhaled corticosteroid therapy can control asthma, but details concerning their effectiveness in achieving this goal in the community are lacking.…”
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A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality by Jain Nem Kumar, Tailang Mukul, Thangavel Neelaveni, Makeen Hafiz A., Albratty Mohammed, Najmi Asim, Alhazmi Hassan Ahmad, Zoghebi Khalid, Alagusundaram Muthumanickam, Jain Hemant Kumar, Chandrasekaran Balakumar

“…Several FGFR inhibitors have been developed for addressing these genetically altered FGFR-harboring malignancies, and some have performed well in clinical trials. In contrast, others are still being investigated in different phases of clinical trials. …”
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Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies by Natascia Brondino, Simona Re, Annalisa Boldrini, Antonella Cuccomarino, Niccolò Lanati, Francesco Barale, Pierluigi Politi

“…In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. …”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.…”
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Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions by Shigeo Koido, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri

“…Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce antitumor immune responses against tumors have been tested in clinical trials worldwide. Although DCs-based vaccine such as fusions of whole tumor cells and DCs has been proven to be clinically safe and is efficient to enhance antitumor immune responses for inducing effective immune response and for breaking T-cell tolerance to tumor-associated antigens (TAAs), only a limited success has occurred in clinical trials. …”
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Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy by Adam Romanovsky, Sean Bagshaw, Mitchell H. Rosner

“…Continued clinical trials with these agents are needed to determine their specific role in the treatment of both chronic and decompensated heart failure.…”
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A survey of obstetric ultrasound uses and priorities for artificial intelligence-assisted obstetric ultrasound in low- and middle-income countries by Amy Sarah Ginsburg, Zylee Liddy, Eren Alkan, Kayla Matcheck, Susanne May

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Effect of Sodium Hypochlorite Concentration on the Outcome of Full Pulpotomy in Mature Permanent Teeth with Irreversible Pulpitis – A Systematic Review by Aakriti Saini, Amandeep Kaur, Sidhartha Sharma, Vijay Kumar, Amrita Chawla, Ajay Logani

“…Electronic searches were performed in PubMed, Embase, Web of Science, International Clinical Trials Registry Platform, and ClinicalTrials.gov for English language articles until July 2021. …”
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Polatuzumab vedotin combined with bendamustine and rituximab for relapsed/refractory diffuse large B-cell lymphoma: A systematic review protocol. by Mohammadreza Eslami, Mahdi Mehrabi, Mehrdad Payandeh, Fakhredin Saba

“…A comprehensive search will be conducted across databases such as Medline/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE, ProQuest, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from the January 2000 to April 2024. …”
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TZDs and Bone: A Review of the Recent Clinical Evidence by Ann V. Schwartz

“…Increased fracture risk in women, but not men, was reported for both TZDs, based on analyses of adverse event reports from clinical trials. In short-term clinical trials in women, both TZDs caused more rapid bone loss. …”
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Statistical Inference of the Class of Nonparametric Tests for the Panel Count and Current Status Data from the Perspective of the Saddlepoint Approximation by Abd El-Raheem M. Abd El-Raheem, Mona Hosny, Ehab F. Abd-Elfattah

“…Equal allocation of both treatments is a largely prevalent approach in clinical trials to eliminate experimental bias and increase power. …”
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Optimizing non-invasive vagus nerve stimulation for treatment in stroke by Sheharyar S. Baig, Samantha Dorney, Mudasar Aziz, Simon M. Bell, Ali N. Ali, Li Su, Jessica N. Redgrave, Arshad Majid

“…In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. …”
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Medicinal products used for the treatment and prophylaxis of COVID-19 by A. Vaitkevičius

“…Data on newly initiated clinical trials on medicinal products for the treatment and prevention of COVID-19 are also provided. …”
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