Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…Yixian Liu,1,2,* Xiaoyu Li,1,2,* Mengyu Zhang,1,2 Yuchun Men,1,2 Ying Wang,1,2 Xiaohong Zhu,1,2 Li Zheng1,2 1Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Clinical Trial Center, NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zheng, Cancer Center, West China Hospital, Sichuan University, No. 5 Telecom Road, Wuhou District, Chengdu, 610041, People’s Republic of China, Email zhengli@wchscu.cnPurpose: HA121-28, a novel multi-targeting tyrosine kinase inhibitor, has dual efficacy against tumor growth and neovascularization. …”
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Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes by Yukiko Kikuchi, Mohammed Uddin, Joris A. Veltman, Sara Wells, Christopher Morris, Marc Woodbury-Smith

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Outcomes following Placement and Removal of Transvaginal Cerclage in at Risk Pregnancies: A Single Center Experience by Henry Adekola, Jennifer Addo, Elizabeth Ramsey Unal, Emma James, Vivek Prakash, Robert Abrams

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Clinical Outcomes of “U” Route Transforaminal Percutaneous Endoscopic Lumbar Discectomy in Chronic Pain Patients with Lumbar Spinal Stenosis Combined with Disc Herniation by Binbin Wu, Xinyi Tian, Ce Shi, Chenchen Jiang, Jing Zhang, Gonghao Zhan, Danli Xie

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Defining patient-reported outcomes in diabetes, obesity, cardiovascular disease, and chronic kidney disease for clinical practice guidelines - perspectives of the taskforce of the... by Katharine Barnard-Kelly, Tadej Battelino, Frank C. Brosius, Antonio Ceriello, Francesco Cosentino, James R. Gavin, Francesco Giorgino, Jennifer Green, Linong Ji, Monika Kellerer, Sue Koob, Mikhail Kosiborod, Nebojsa Lalic, Nikolaus Marx, Prashant Nedungadi, Christopher G. Parkin, Helena W. Rodbard, René D. Rötzer, Lars Rydén, Wayne Huey-Herng Sheu, Eberhard Standl, Britta Tendal Jeppesen, Pinar Topsever, Per Olav Vandvik, Christoph Wanner, Oliver Schnell

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Effect of oxytocin nasal spray pretreatment on postoperative acute stress disorder in patients with accidental traumatic fracture: a single-centre prospective randomised controlled... by Ling Ren, Qingqing Huang, Hengdi Zhang, Jingzheng Zeng, Yi Wen, Haifeng Shu, Gu Gong

“…The exploratory results include the concentrations of stress response indicators such as malondialdehyde, cortisol and superoxide dismutase in the saliva before the first intervention and on days 1–3 after surgery.Ethics and dissemination The trial was approved by the clinical research ethics committee of the General Hospital of the Western Theater Command (identifier: 2024EC3-ky014). …”
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Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy by Alireza Tabibkhooei, Maziar Azar, Mohsen Nabiuni, Javad Jahandideh, Mohsen Benam, Farid Qoorchi Moheb Seraj, Feizollah Ebrahimnia, Ali Moradi

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A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation by Ayesha Juhi, Manul Das, Dinesh Bhatia, Suman Dhaka, Rajesh Kumar, Deepak Kumar, Shreya Sharma, Pritam Kumar Chaudhary, Chanchal Goyal, Md Asif Khan, Himel Mondal

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Antibacterial activity and impact on keratinocyte cell growth of Cutibacterium acnes bacteriophages in a Cutibacterium acnes IA1- colonized keratinocyte model by Juan C Farfán-Esquivel, María Victoria Gutiérrez, Alejandro Ondo-Méndez, John M González, Martha J Vives-Flórez

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Early dual antiplatelet therapy (DAPT) administration within 6 h post-coronary artery bypass grafting (CABG): an audit, pilot study, and follow-up analysis by Yen Chuan Chen, Khairul Anuar Abdul Aziz, Mohamed Ezani Md Taib, Alwi Mohamed Yunus, Intan Fariza Gaaffar

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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication by Ryoya Sekine, Kouki Takeda, Tsukasa Suenaga, Satsuki Tsuno, Takumi Kaiya, Maki Kiso, Seiya Yamayoshi, Yoshihide Takaku, Shiho Ohno, Yoshiki Yamaguchi, Seiichi Nishizawa, Kazuhiro Sumitomo, Kazufumi Ikuta, Teru Kanda, Yoshihiro Kawaoka, Hidekazu Nishimura, Shusuke Kuge

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SPAGRM: effectively controlling for sample relatedness in large-scale genome-wide association studies of longitudinal traits by He Xu, Yuzhuo Ma, Lin-lin Xu, Yin Li, Yufei Liu, Ying Li, Xu-jie Zhou, Wei Zhou, Seunggeun Lee, Peipei Zhang, Weihua Yue, Wenjian Bi

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Intestinal microbiota as biomarkers for different colorectal lesions based on colorectal cancer screening participants in community by Gairui Li, Gairui Li, Dan Zhao, Binfa Ouyang, Yinggang Chen, Yashuang Zhao

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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…We provide a brief overview of the cellular expression and function of these targets, noting their selectivity for astrocytes and/or microglia, and highlight the classes of PET radiotracers that have been investigated in early-stage preclinical or clinical research studies of neuroinflammation.…”
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Diagnosis Osteoporosis Risk: Using Machine Learning Algorithms Among Fasa Adults Cohort Study (FACS) by Saghar Tabib, Seyed Danial Alizadeh, Aref Andishgar, Babak Pezeshki, Omid Keshavarzian, Reza Tabrizi

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Demographic and motivational factors affecting the whole-body donation programme in Nanjing, China: a cross-sectional survey by Li Yuan, Jiayi Jiang, Mingyi Zhang, Haojie Meng, Xiang Cui, Yuxin Yang, Chuan Su, Jinfan Wang, Luqing Zhang

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Facilitators and barriers affecting the implementation of e-health for chronic respiratory diseases in remote settings: a qualitative evidence synthesis by Emil Matias Salmi, Francesca Wanda Basile, Faiz Ahmad Khan, Larry Watt, Rinn Song, Else Margreet Bijker

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Development trend of primary healthcare after health reform in China: a longitudinal observational study by Hui Li, Jie Feng, Zuxun Lu, Yanhong Gong, Xuan Zhou, Guopeng Zhang, Xiaoxv Yin, Jianxiong Wu

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Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction by Zheping Chen, Zhenxiang Zuo, Yizheng Zhang, Guoliang Shan, Le Zhang, Moxuan Gong, Yuyang Ye, Yufeng Ma, Yanwu Jin

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Scalable information extraction from free text electronic health records using large language models by Bowen Gu, Vivian Shao, Ziqian Liao, Valentina Carducci, Santiago Romero Brufau, Jie Yang, Rishi J. Desai

“…Further refinement and domain-specific training could enhance their utility in clinical research and predictive analytics, improving healthcare outcomes and addressing health disparities.…”
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