Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance by Xia-Lu Hong, Chen-Kai Huang, Hui Qian, Chen-Hong Ding, Fang Liu, Huan-Yu Hong, Shu-Qing Liu, Si-Han Wu, Xin Zhang, Wei-Fen Xie

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Prevalence and clinical profile of hepatitis C virus infections in multitransfused thalassemic patients in the capital twin cities of Pakistan by Z. Z. Piracha, U. Saeed, R. Uppal, M. R. Uppal, A. Ahmad Khan, M. Abdullah, K. Mari, A. Basra, S. S. Gilani, M. N. Tariq, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…This study aimed to assess the prevalence of hepatitis C virus infections among multitransfused thalassemic patients in the twin cities of Pakistan's capital. The clinical research, involving the enrollment of 262 multitransfused beta thalassemic patients residing in the capital twin cities of Pakistan. …”
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Association of dietary acid load with inflammatory markers, oxidative stress, and clinical features in patients with knee osteoarthritis by Jalal Moludi, Akram Rahimi, Shaimaa A. Qaisar, Soudabeh Hamedi-Shahraki, Farshad Amirkhizi

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Evaluation of acute plant toxicity, antioxidant activity, molecular docking and bioactive compounds of lemongrass oil isolated from Omani cultivar by Haneen Al Weshahi, Mohammad Sohail Akhtar, Salem Said Al Tobi, Amzad Hossain, Shah Alam Khan, Alia Bushra Akhtar, Sadri Abdullah Said

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Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients by Yiliang Meng, Kai Cai, Jingjie Zhao, Keyu Huang, Xiumei Ma, Jian Song, Yunguang Liu

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Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebo-controlled study by Yoshiya Tanaka, Yosuke Okada, Tetsuya Kawahara, Gen Suzuki, Tetsuya Inazu, Shoichi Mizuno, Fumiyoshi Kasagi

“…Follow-up is estimated to span 144 weeks.Ethics and dissemination All protocols and an informed consent form comply with the Ethics Guideline for Clinical Research (Japan Ministry of Health, Labour and Welfare). …”
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Skin Metabolic Signatures of Psoriasis and Psoriasis Concurrent with Metabolic Syndrome by Yan L, Wang W, Dong M, Wang R, Li C

“…Liang Yan,1,2 Wenqiu Wang,1 Meihan Dong,1 Rui Wang,1 Chengxin Li1,3 1Department of Dermatology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Dermatology, General Hospital of Central Theater Command of PLA, Wuhan, 430070, People’s Republic of China; 3State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, 100853, People’s Republic of ChinaCorrespondence: Chengxin Li; Rui Wang, Department of Dermatology, The First Medical Center of Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China, Tel +86-01066939315 ; +86-01066939314, Email chengxinderm@163.com; wr0699@163.comPurpose: Psoriasis is a complex inflammatory skin disorder that is closely associated with metabolic syndrome (MetS). …”
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Applications of MDMA in Modern Medicine - A Literature Review by Wiktoria Podlasiewicz, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Tomaszewska, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“…Despite the highly promising results of MDMA- assisted therapy so far, additional clinical research is crucial to enable this drug to revolutionise future treatment methods. …”
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Arsenic and fifteen other metal (loid)s exposure of children living around old mines in the south of France by Igor Pujalté, Zeno Loi, Alice Bernard, Lionel Moulis, Sophie Delpoux, Jacques Gardon

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CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its Association with Immune Infiltrates in Ovarian Cancer by Pan Hu, Li Lei, Ying Wang, Xue Tian, Xia Wei, Ni Jiang, Lubin Liu

“…Patients with high CLDN4 expression predicted a shorter overall survival (OS) and disease-specific survival (DSS) than those with low CLDN4 expression, according to clinical research. Patients with low CLDN4 expression predicted longer OS and DSS. …”
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Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy by Jia Lv, Xinyu Gao, Lihua Liu, Libing He, Geng Tian, Xuehong Lu

“…This study preliminarily reveals the possible mechanism of KX in the treatment of IMN and provides a theoretical basis for future clinical research.…”
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Successful Treatment of Caesarean Scar Pregnancies by Local Treatment Only by Shinji Tanigaki, Chie Nagata, Kazunori Ueno, Nobuaki Ozawa, Shinichi Nagaoka, Kei Tanaka, Haruhiko Sago, Mitsutoshi Iwashita

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Process Assessment of Fencer's Parents within the scope of the Covid-19 Normalization Steps by Yusuf Barsbuğa

“…For this study, an approval was received from the Ethics Committee for Non-Invasive Clinical Research of the School of Sport Sciences of Seljuk University. …”
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Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway by Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng

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Evaluation of the efficacy of low concentration fluoride gel using custom trays to prevent radiation-related dental caries in patients with head and neck cancer: protocol for a ran... by Yumiko Kawashita, Masahiro Umeda, Toshiyuki Saito, Sakiko Soutome, Souichi Yanamoto, Maho Murata, Masako Yoshimatsu, Madoka Funahara

“…Target accrual is 80 patients with a two-sided type I error rate of 5% and 80% power to detect 80% risk reduction.Ethics and dissemination This study was approved by the Clinical Research Review Board in Nagasaki University The protocol of this study was registered at Japan Registry of Clinical Trials (jRCT) and University hospital Medical Information Network Clinical Trials Registry (UMIN). …”
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Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Few of the identified drug targets for AD have been clinically tractable, and phenotypic heterogeneity is an obstacle to both clinical research and basic science. In four cohorts (n = 7241), we performed genome-wide association studies (GWAS) and Mendelian randomization (MR) to discover novel targets associated with progression and assess causal relationships. …”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

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A Meta-Analysis of a Cohort Study on the Association between Sleep Duration and Type 2 Diabetes Mellitus by Huapeng Lu, Qinling Yang, Fang Tian, Yi Lyu, Hairong He, Xia Xin, Xuemei Zheng

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Mortal consequences of a cooperative action between Takotsubo syndrome and increased intracranial pressure by Gennaro Alfano, Deasy Ciervo, Teresa Migliore, Antonia Sorbo, Manuela Ariello, Andrea Vitale, Mikko O. Laukkanen, Salvatore Del Gaudio

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Indigenous university students' perceptions regarding nature, their daily lives and climate change: a photovoice study by Ieda M. A. V. Dias, Antonio Jose Grande, Paulo T. C. Jardim, Alessandra Aparecida Vieira Machado, Jacks Soratto, Maria Inês da Rosa, Luciane Bisognin Ceretta, Leonardo Roever, Xanthi Zourntos, Seeromanie Harding

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