Preparedness for and impact of COVID-19 on primary health care delivery in urban and rural Malawi: a mixed methods study by Tracy Morse, Kondwani Chidziwisano, Gift Kawalazira, Mackwellings Maganizo Phiri, Eleanor Elizabeth MacPherson, Mindy Panulo, Khumbo Kalua, Chawanangwa Mahebere Chirambo, Zaziwe Gundah, Penjani Chunda

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ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis by Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang, Jinghua Jiang, Qiudong Zhao, Lixin Wei, Li Zhang, Zhipeng Han, Wenting Liu, Jianxin Qian

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A Rare Case of Spontaneous Heterotopic Pregnancy at 12 weeks of Gestation Following Natural Conception With Literature Review by Wang F, Xu Y, Dong X, Jiang P, Yu QQ

“…Fei Wang,1,* Yuting Xu,1,* Xin Dong,2 Pei Jiang,3 Qing-Qing Yu4 1Department of Gynecology, Jining No.1 People’s Hospital, Jining, People’s Republic of China; 2Department of Ultrasonography, Jining No.1 People’s Hospital, Jining, People’s Republic of China; 3Translational Pharmaceutical Laboratory, Jining NO.1 People’s Hospital Jining, People’s Republic of China; 4Clinical Research Center, Jining NO.1 People’s Hospital, Jining, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing-Qing Yu, Clinical Research Center, Jining No.1 People’s Hospital, Jining, People’s Republic of China, 272011, Email yuqingqing_lucky@163.com Pei Jiang, Translational Pharmaceutical Laboratory, Jining No.1 People’s Hospital, Jining, 272011, People’s Republic of China, Email jiangpeicsu@sina.comBackground: Spontaneous heterotopic pregnancy is an uncommon and possibly serious problem characterized by maternities at unique implantation sites, with only one occurring in the intrauterine cavity. …”
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Enablers of Physician Prescription of a Long-Term Asthma Controller in Patients with Persistent Asthma by Francine M. Ducharme, Alexandrine J. Lamontagne, Lucie Blais, Roland Grad, Kim L. Lavoie, Simon L. Bacon, Martha L. McKinney, Eve Desplats, Pierre Ernst

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Using Large Language Models to Detect and Understand Drug Discontinuation Events in Web-Based Forums: Development and Validation Study by William Trevena, Xiang Zhong, Michelle Alvarado, Alexander Semenov, Alp Oktay, Devin Devlin, Aarya Yogesh Gohil, Sai Harsha Chittimouju

“…ObjectiveThe aim of this study is to provide a flexible framework for investigating various clinical research questions in data-sparse environments. …”
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Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systematic review and meta-analysis by Idrees A. Shah, Rabiya Rashid, Haroon Rashid, Abid Bhat, Mohd Ashraf Ganie

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Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer by Zhang JN, Li LW, Cao MQ, Liu X, Yi ZL, Liu SS, Liu H

“…Jia-Ning Zhang,1,2,* Lin-Wei Li,1,2,* Man-Qing Cao,1,2,* Xin Liu,1,2 Zi-Lu Yi,1,2 Sha-Sha Liu,1,2 Hong Liu1,2 1The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China; 2Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Liu, Email liuhong_submit@tjmuch.comPurpose: Cell division cycle protein 45 (CDC45) plays a crucial role in DNA replication. …”
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Predicting Time to First Rejection Episode in Lung Transplant Patients Using a Comprehensive Multi-Indicator Model by Chen Y, Li E, Yang Q, Chang Z, Yu B, Lu J, Wu H, Zheng P, Cheng ZJ, Sun B

“…Youpeng Chen,1,* Enzhong Li,2,* Qingqing Yang,1 Zhenglin Chang,1 Baodan Yu,1 Jiancai Lu,1 Haojie Wu,1 Peiyan Zheng,1 Zhangkai J Cheng,1,* Baoqing Sun1 1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, People’s Republic of China; 2Department of Endocrinology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhangkai J Cheng; Baoqing Sun, Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, People’s Republic of China, Email jasontable@gmail.com; sunbaoqing@vip.163.comBackground: Rejection hinders long-term survival in lung transplantation, and no widely accepted biomarkers exist to predict rejection risk. …”
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Knockdown of RFC4 inhibits cell proliferation of oral squamous cell carcinoma in vitro and in vivo by Pengyue You, Di Wang, Zheng Liu, Shuzhen Guan, Ning Xiao, Haotian Chen, Xin Zhang, Lichuan Wu, Guizhen Wang, Haitao Dong

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Characterizing the medical and social complexity experienced by Inuit children and their families from Nunavut who access care at an urban Canadian tertiary level paediatric hospit... by Yipeng Ge, Amanda Mills, Victoria McCann, Sara Trincao-Batra, Deepti Reddy, Dennis Newhook, Richard J. Webster, Stephanie Sutherland, Melissa Weber, Radha Jetty

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The CuePed Trial: How Does Environmental Complexity Impact Cue Effectiveness? A Comparison of Tonic and Phasic Visual Cueing in Simple and Complex Environments in a Parkinson’s Dis... by Rodney Marsh, Michael H. Cole, Nadeeka N. W. Dissanayaka, Tiffany R. Au, Sandra Clewett, John D. O’Sullivan, Peter A. Silburn

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Serum-Free Culture System for Spontaneous Human Mesenchymal Stem Cell Spheroid Formation by Guoyi Dong, Shengpeng Wang, Yuping Ge, Qiuting Deng, Qi Cao, Quanlei Wang, Zhouchun Shang, Wenjie OuYang, Jing Li, Chao Liu, Jie Tang, Weihua Zhao, Ying Gu

“…Human mesenchymal stem cells (hMSCs) are widely used in clinical research because of their multipotential, immunomodulatory, and reparative properties. …”
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Hufu Tongbian Guasha in the treatment of bloating and constipation in a patient with cholestatic jaundice (虎符铜砭刮痧改善1例胆汁淤积性黄疸患者腹胀和便秘的护理)... by WANG Rui (王蕊), HU Jinrui (胡金瑞)

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Beyond the storms: Exploring predictors of posttraumatic stress and posttraumatic growth among survivors of hurricanes Irma and Maria in Puerto Rico by Marie-Claire Meadows, Noelle Serino, Dahianira M. Camacho-Monclova, Kaumudi Joshipura, Sarah R. Lowe

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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

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Direct anterior and direct lateral approach in patients with femoral neck fractures receiving a total hip arthroplasty: a randomized controlled trial by John Magne Hoseth, Tommy Frøseth Aae, Øystein Bjerkestrand Lian, Tor Åge Myklebust, Otto Schnell Husby

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Impact of remnant cholesterol on acute ischemic stroke prognosis: a nationwide cohort analysis stratified by non-alcoholic fatty liver disease status by Sili Jiang, Aoming Jin, Aoming Jin, Wenli Xing, Jing Jing, Jing Jing

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The Association of Occipital Spur with Craniocervical Posture and Craniofacial Morphology by Cheng Q, Xiao C, Lau Rui Han S, Hu S, Wu X, Dong Y, Xiong X, Fang S

“…Qiaoyu Cheng,1 Chuqiao Xiao,1 Sophie Lau Rui Han,1 Shoushan Hu,1 Xiayanran Wu,1 Yanhua Dong,1 Xin Xiong,1 Shanbao Fang2 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 2Department of Orthodontics, College & Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of ChinaCorrespondence: Xin Xiong, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Email drxiongxin@scu.edu.cn Shanbao Fang, Department of Orthodontics, College & Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China, Email fangshanbao@gxmu.edu.cnPurpose: This cross-sectional study aimed to evaluate the relationship between occipital spur (OS) with both craniocervical posture and craniofacial morphology.Methods: The study involved 240 lateral cephalograms from subjects with and without OS. …”
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Bibliometric insights into astrocytic roles in depression and treatment by Linsun Lin, Linsun Lin, Ziyi Guo, Zhuoyu Ren, Yanchen Feng, Peigang Fang, Tao Wang, Min Chen, Min Chen

“…We hope that this study will facilitate a broader integration of basic and clinical research, offering novel approaches for the treatment of depression.…”
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Glaucomatous Visual Field Defect Severity and the Prevalence of Motor Vehicle Collisions in Japanese: A Hospital/Clinic-Based Cross-Sectional Study by Takeshi Ono, Kenya Yuki, Ryo Asaoka, Keisuke Kouyama, Takayuki Abe, Sachiko Tanabe, Kazumi Fukagawa, Miki Uchino, Masaru Shimoyama, Yoko Ozawa, Naoki Ozeki, Daisuke Shiba, Kazuo Tsubota

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