Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical... by Jiangtao Bai, Tetsuya Asakawa, Wenfang Yuan, Yuanlong Lin, Hao Ju, Dandan Xu, Mingming Yang, Shuo Li, Guanguan Li, Deyin Guo, Hongzhou Lu, Xumu Zhang

Get full text

Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

Get full text

Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma ≤3 cm in Potentially Transplantable Patients: A Over 1... by Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

“…Shuanggang Chen,1,2,* Han Qi,1,2,* Hongtong Tan,1,2,* Fei Cao,1,2 Lin Xie,1,2 Tao Huang,1,2 Ying Wu,3 Chunyong Wen,1,2 Yujia Wang,1,2 Lujun Shen,1,2 Weijun Fan1,2 1Department of Minimally Invasive Interventional Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Interventional Therapy, Shenzhen second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weijun Fan, Email fanwj@sysucc.org.cn; Lujun Shen, Email shenlj@sysucc.org.cnBackground: Salvage liver transplantation is promising for hepatocellular carcinoma(HCC) recurrence post-ablation but is significantly affected by recurrence beyond Milan Criteria (RBM).Materials and Methods: A retrospective cohort study of potentially transplantable HCC patients undergoing ablation between 2007 and 2017 assessed median time to recurrence beyond Milan Criteria(TRBM) via Kaplan-Meier curves and predictive capacity of recurrence and RBM for overall survival(OS) via Receiver Operating Characteristic Curves, and identified independent risk factors for TRBM and RBM via Cox and binary logistic regression models.Results: We enrolled 191 potentially transplantable patients with early-stage HBV-related HCC ≤ 3 cm who underwent ablation. …”
Get full text

Delayed Graft Function in Kidney Transplants: Time Evolution, Role of Acute Rejection, Risk Factors, and Impact on Patient and Graft Outcome by Martin Chaumont, Judith Racapé, Nilufer Broeders, Fadoua El Mountahi, Annick Massart, Thomas Baudoux, Jean-Michel Hougardy, Dimitri Mikhalsky, Anwar Hamade, Alain Le Moine, Daniel Abramowicz, Pierre Vereerstraeten

Get full text

Serum 25‐Hydroxyvitamin D Levels and Survival Outcomes in Advanced Biliary Tract Cancer: Results From the NIFTY Trial by So Heun Lee, Jaekyung Cheon, Ilhwan Kim, Kyu‐pyo Kim, Baek‐Yeol Ryoo, Jae Ho Jeong, Myoung Joo Kang, Byung Woog Kang, Hyewon Ryu, Ji Sung Lee, Changhoon Yoo

Get full text

An AI recognition method for children's clinical operative pain by skin potential (SP) signal by Mingxuan Huang, Cangcang Fu, Linbo Chui, Jiadong He, Xiaozhi Wang, Jikui Luo, Bin Wu, Yonggang Chen, Shaohua Hu, Jihua Zhu, Yubo Li

Get full text

Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study by Xiao S, Ou J, Qiu W, Ye C, Li N, Chen S, Lai Y, Deng Z, Wu F, Shen Y

“…Shan Xiao,1,&ast; Jie Ou,2,&ast; Wangli Qiu,3,&ast; Chunxin Ye,1 Na Li,1 Sida Chen,1 Yuting Lai,1 Zhishan Deng,4 Fan Wu,4 Yan Shen1 1Department of Pulmonary and Critical Care Medicine, Shenzhen Longgang District Central Hospital, Shenzhen, People’s Republic of China; 2State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, People’s Republic of China; 4State Key Laboratory of Respiratory Disease & Guangzhou Institute of Respiratory Health & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Shen, Email drshenyan2022@163.com Fan Wu, Email wu.fan@vip.163.comBackground: Preserved ratio impaired spirometry (PRISm) is defined as forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)≥ 0.70 and FEV1< 80% predicted. …”
Get full text

Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…By using aggregate level, routinely collected data for the coprimary outcomes, we removed the need to recruit individual participants.Setting Primary care.Participants Baseline data from general practitioner practices and interviews with individuals from Clinical Research Networks (CRNs) in England who helped recruit practices and Clinical Commission Groups (CCGs) who collected outcome data.Intervention The intervention included: (1) explicit elicitation of parental concerns, (2) a prognostic algorithm to identify children at low risk of hospitalisation and (3) provision of a printout for carers including safety-netting advice.Coprimary outcomes For 0–9 years old—(1) Dispensing data for amoxicillin and macrolide antibiotics and (2) hospital admission rate for RTI.Results We recruited 294 of the intended 310 practices (95%) representing 336 496 registered 0–9 years old (5% of all 0–9 years old children). …”
Get full text

The Diagnostic Value of Bile Acids and Amino Acids in Differentiating Acute Coronary Syndromes by Yu Q, Zhao F, Wang S, Jia X, Shen S, Zhao X, Li Y, Song J, Sun M, Liu X, Liu Z

“…Qian Yu,1– 3,&ast; Furong Zhao,3,4,&ast; Shuang Wang,4 Xingwang Jia,1,5 Shuang Shen,2 Xiaofeng Zhao,2 Ying Li,3,4 Jiaolei Song,2 Miao Sun,1,5 Xin Liu,1,2 Zhining Liu1,6 1Post Graduate School of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China; 2Huludao Central Hospital Teaching Base of Jinzhou Medical University, Huludao, Liaoning, People’s Republic of China; 3Liaoning Provincial Key Laboratory of Clinical Oncology Metabolomics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China; 4Clinical Research department, Dalian Boyuan Medical Technology Co., Ltd, Dalian, Liaoning, People’s Republic of China; 5Department of Laboratory Medicine, General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group, Fushun, Liaoning, People’s Republic of China; 6Ultrasound Department, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhining Liu, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, People’s Republic of China, Tel +86 15941695215, Email liuzhiningfuyi@163.com Xin Liu, Huludao Central Hospital Teaching Base of Jinzhou Medical University, Huludao, Liaoning, 125001, People’s Republic of China, Tel +86 15941695215, Email lyy66112@163.comPurpose: Acute coronary syndrome (ACS), comprising unstable angina and acute myocardial infarction, is the most dangerous and fatal form of coronary heart disease. …”
Get full text

Relationship between obesity indicators and hypertension–diabetes comorbidity among adults: a population study from Central China by Li Li, Ling Li, Ying Wang, Wenwen Wu, Xiaodong Tan, Fen Yang, Jinru Yang, Yifan Wu, Donghan Sun, Ziling Ni, Yaofei Xie

Get full text

Immunogenicity of the 9-valent human papillomavirus vaccine: Post hoc analysis from five phase 3 studies by Anna R. Giuliano, Joel M. Palefsky, Stephen E. Goldstone, Jacob Bornstein, Ilse De Coster, Ana María Guevara, Ole Mogensen, Andrea Schilling, Pierre Van Damme, Corinne Vandermeulen, Misoo C. Ellison, Susan Kaplan, Jianxin Lin, Rachael Bonawitz, Alain Luxembourg

Get full text

Impaired Sphenoparietal Venous Drainage Is Associated With Increased Risk of Vasospasm in Aneurysmal Subarachnoid Hemorrhage by Kyle A. Lyman, Gautam Adusumilli, Hera A. Kamdar, Joanna Yang, Guy A. Rordorf, Daniel B. Rubin, Robert W. Regenhardt, Christopher J. Stapleton, Aman B. Patel, Joseph J. Locascio, William Taylor Kimberly, Brian L. Edlow, Jeremy J. Heit, David Y. Chung

Get full text

TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD by Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang

Get full text

The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation by Mark Bitsch Vestergaard, Aftab Bakhtiari, Merete Osler, Erik Lykke Mortensen, Ulrich Lindberg, Ian Law, Martin Lauritzen, Krisztina Benedek, Henrik Bo Wiberg Larsson

Get full text

Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model by Zigui Chen, Chunyuan Zhang, Yuhua Fang, He Zhang, Jiawei Luo, Changfeng Miao, Jiale Li, Jun Peng, Yingqi Qiu, Ying Xia, Qisheng Luo

Get full text

Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling by Lu Wang, Fangzheng Hu, Qianqian Cui, Huarui Qiao, Lingyun Li, Tengjie Geng, Yuying Li, Zengchao Sun, Siyu Zhou, Zhongyun Lan, Shaojue Guo, Ying Hu, Jiqiu Wang, Qilun Yang, Zenan Wang, Yuanyuan Dai, Yong Geng

Get full text

Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation by Ting Shen, Jing Yu, Bin Xie, Cuiping Huang, Jingjie Cui, Kefu Liu, Chunyu Liu, Chao Chen

Get full text

Does completion of radical hysterectomy improve oncological outcomes of women with clinical early-stage cervical cancer and intraoperative detection of nodal involvement?: protocol... by Hui Xu, Qing Liu, Yu Xu, Yi Du, Ai Zheng, Cui Hu, Ya Jia, Qianwen Zhang, Yue-Dong He, Shuang-Shuang Cui, Yong Tian, Lin Ran, Fengmei Ke

Get full text

Benzodiazepine agonist treatment for patients with benzodiazepine dependence undergoing opioid agonist treatment: a study protocol for the randomized controlled trial BMX-BAR by Fatemeh Chalabianloo, Lars Thore Fadnes, Jörg Assmus, Jon Mordal, Kristin K. Solli, Kjetil S. Dale, Christina D. Andersen, Silvia Zavenova, Beathe H. Rønning, Andreas W. Blomkvist, Martin Ryssdal, Wasifa S. J. Butt, Anne Marciuch, Anne G. Ørmen, Christian Ohldieck, Else-Marie Løberg, Kjell Arne Johansson, for the BMX-BAR and NORCATS study group

Get full text

Association Between Metabolic Syndrome and Cardiac Autonomic Nervous Function and Cardiorespiratory Fitness in Older Adults: A Retrospective Observational Study with Propensity Sco... by Cui N, Li Q, Cheng J, Xing T, Shi P, Wang Y, Luo M, Dun Y, Liu S

“…Ni Cui,1,&ast; Qiuxia Li,1,&ast; Jing Cheng,2,&ast; Tianhua Xing,1 Peiyao Shi,3 Yingmei Wang,2 Min Luo,2 Yaoshan Dun,1,4 Suixin Liu1,4 1Division of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, People’s Republic of China; 2Department of Cardiovascular medicine, Shenzhen District Yantian People’s Hospital, Shenzhen, Guangdong, 518081, People’s Republic of China; 3Department of Experimental Diagnosis, Shenzhen District Yantian People’s Hospital, Shenzhen, Guangdong, 518081, People’s Republic of China; 4National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Suixin Liu; Yaoshan Dun, Division of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, People’s Republic of China, Email liusuixin@csu.edu.cn; dunyaoshan@csu.edu.cnBackground: Delayed heart rate recovery (HRR) after exercise, an indicator of cardiac autonomic nervous function (CANF), has been found to be associated with metabolic syndrome (MetS) in general populations. …”
Get full text