Correlation between hemoglobin, albumin, lymphocyte, and platelet score and short-term mortality in critically ill patients by Chong Zhang, Wenjin Peng, Meng Ning, Weiru Liang, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Yingwu Liu

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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

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Efficiency and safety of HAIC combined with lenvatinib and tislelizumab for advanced hepatocellular carcinoma with high tumor burden: a multicenter propensity score matching analys... by Zhonghua Zhao, Xiongying Jiang, Shiping Wen, Yanzhang Hao

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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Development of a Transcultural Social Ethical and Integrated Care Model, for Dependent and Older People Populations at Risk of Exclusion in the Mediterranean Sea Basin (TEC-MED): A... by Ana María Porcel-Gálvez, Elena Fernández-García, Soledad Vázquez-Santiago, Sergio Barrientos-Trigo, María Dolores Mateos-Garcia, Mercedes Bueno-Ferrán, Jalila El Ati, Hajer Aounallah-Skhiri, Marta Lima-Serrano

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The American Society of Pain and Neuroscience (ASPN) Guidelines and Consensus on the Definition, Current Evidence, Clinical Use and Future Applications for Physiologic Closed-Loop... by Pope JE, Deer TR, Sayed D, Antony AB, Bhandal HS, Calodney AK, Chakravarthy K, Costandi S, Diep J, Durbhakula S, Fishman MA, Gilligan C, Goree JH, Guirguis M, Hagedorn JM, Hunter CW, Kallewaard JW, Kapural L, Lam CM, Li S, Mayrsohn B, Nijhuis H, Nikolic S, Petersen EA, Poree LR, Puri SK, Reece DE, Rosen SM, Russo MA, Shah JM, Staats PS, Verrills P, Vu CM, Levy RM, Mekhail N

“…Jason E Pope,1 Timothy Ray Deer,2 Dawood Sayed,3 Ajay B Antony,4 Harjot Singh Bhandal,1 Aaron K Calodney,5 Krishnan Chakravarthy,6 Shrif Costandi,7 Jack Diep,8 Shravani Durbhakula,9 Michael A Fishman,10 Christopher Gilligan,11 Johnathan Heck Goree,12 Maged Guirguis,13 Jonathan Michael Hagedorn,14 Corey William Hunter,15,16 Jan Willem Kallewaard,17,18 Leonardo Kapural,19– 21 Christopher M Lam,3 Sean Li,22 Brian Mayrsohn,23,24 Harold Nijhuis,25 Serge Nikolic,26 Erika A Petersen,27 Lawrence Raymond Poree,28 Shawn K Puri,29 David E Reece,30 Steven Mark Rosen,31 Marc A Russo,32 Jay M Shah,33 Peter Sean Staats,34 Paul Verrills,35 Chau M Vu,1 Robert M Levy,36 Nagy Mekhail37 1Evolve Restorative Center, Santa Rosa, CA, USA; 2Pain Services, The Spine & Nerve Center of the Virginias, Charleston, WV, USA; 3Department of Anesthesiology and Pain Medicine, The University of Kansas Medical Center, Kansas City, KS, USA; 4The Orthopaedic Institute, Gainesville, FL, USA; 5Clinical Research, Precision Spine Care, Tyler, TX, USA; 6Anesthesiology and Pain Medicine, Solaris Research Institute, Wilmington, DE, USA; 7Pain Medicine, Cleveland Clinic, Cleveland, OH, USA; 8Nevada Pain Management, Las Vegas, NV, USA; 9Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA; 10Michael Fishman MD PLLC, Lebanon, PA, USA; 11Robert Wood Johnson University Hospital, New Brunswick, NJ, USA; 12Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 13Interventional Pain Management Department, Ochsner Health System, New Orleans, LA, USA; 14Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA; 15Ainsworth Institute of Pain Management, New York City, NY, USA; 16Physical Medicine & Rehabilitation, Icahn School of Medicine at Mount Sinai Hospital, New York City, NY, USA; 17Amsterdam University Medical Centre, Amsterdam, The Netherlands; 18Rijnstate Hospital, Arnhem, The Netherlands; 19Carolinas Pain Institute, Winston Salem, NC, USA; 20Centers for Clinical Research, Winston Salem, NC, USA; 21Chronic Pain Research Institute, Winston Salem, NC, USA; 22National Spine and Pain Centers, Shrewsbury, NJ, USA; 23Interventional Pain Management, Maywell Health, Plainview, NY, USA; 24Interventional Pain Management, Maywell Health, New York City, NY, USA; 25Anesthesiology, St Antonius Hospital, Nieuwegein, Utrecht, The Netherlands; 26Pain Medicine and Neuromodulation, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK; 27Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 28Anesthesia- Division of Pain Medicine, University of California, San Francisco, CA, USA; 29Integrated Pain Associates, Killeen, TX, USA; 30Absolute Pain Management, Rockville, MD, USA; 31Delaware Valley Pain and Spine Institute, Trevose, PA, USA; 32School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia; 33Samwell Institute of Pain Management, Colonia, Livingston, and Englewood, NJ, USA; 34National Spine and Pain Centers, Atlantic Beach, FL, USA; 35Metropain, Melbourne, VIC, Australia; 36Neuromodulation: Technology at the Neural Interface, International Neuromodulation Society, Boca Raton, FL, USA; 37Evidence-Based Pain Management Research, Cleveland Clinic, Cleveland, OH, USACorrespondence: Timothy Ray Deer, The Spine and Nerve Center of the Virginias, 400 Court Street, Charleston, WV, 25304, USA, Tel +1 304 347 6141, Email doctdeer@aol.comIntroduction: Neuromodulation has been a staple of treatment for moderate-to-severe chronic refractory pain since the introduction of the first spinal cord stimulator by Norman Shealy in 1967. …”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

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Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults by Shiqi Yang, Minwen Zhou, Bing Lu, Pengfei Zhang, Jingke Zhao, Mei Kang, Ruoshi Wang, Fenghua Wang, Xiaodong Sun

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Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis by Shuyuan Chang, Ayaka Tomii, Yunfei Zhou, Xun Yang, Yihong Dong, Jun Yan, Aodi Wu, Yumeng Wang, Qingxin Zhang, Hongxue Meng, Lei Yu, Wei Sun, Dabin Liu

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Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

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Lifestyle Intervention Improves Heart Rate Recovery from Exercise in Adults with Type 2 Diabetes: Results from the Look AHEAD Study by Paul M. Ribisl, Sarah A. Gaussoin, Wei Lang, Judy Bahnson, Stephanie A. Connelly, Edward S. Horton, John M. Jakicic, Tina Killean, Dalane W. Kitzman, William C. Knowler, Kerry J. Stewart, Look AHEAD Research Group

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Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy by Yonghua Cai, Heng Xiao, Shuaishuai Xue, Peng Li, Zhengming Zhan, Jie Lin, Zibin Song, Jun Liu, Wei Xu, Qixiong Zhou, Songtao Qi, Xi’an Zhang, Ziyi Luo

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Acupuncture Dosage and Its Correlation with Effectiveness in Patients with Chronic Stable Angina: A Systematic Review and Meta-Analysis of Randomized Controlled Trial by Huang D, Li Y, Zheng X, Hu J, Tang H, Yin Y, Wu Z, Kong L

“…Dajun Huang,1,* Yanwei Li,1,* Xiaoyan Zheng,2,3,* Jinming Hu,1 Hanzhang Tang,1 Yongjun Yin,1 Zhou Wu,1 Lingqiu Kong1 1Department of Cardiovascular Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Clinical Research Center for Acupuncture and Moxibustion in Sichuan province, Sichuan JinXin Xinan Women’s and Children’s Hospital, Chengdu, People’s Republic of China; 3Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingqiu Kong; Zhou Wu, Department of Cardiovascular Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Address: No. 39 Shi’er Qiao Road, Chengdu, Sichuan, 610023, People’s Republic of China, Email klq521@163.com; 1209293923@qq.comObjective: This systematic review aimed to compare the efficacy of various acupuncture dosages for Chronic Stable Angina (CSA) using randomized controlled trials (RCTs), addressing the unclear relationship between dosage and effectiveness despite acupuncture’s potential.Methods: We searched eight bibliographic databases from inception to October 31, 2024, evaluating RCTs comparing acupuncture to placebo or standard care for CSA patients, focusing on angina attack frequency as the primary outcome. …”
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Feline sacroiliac luxation: comparison of fluoroscopy-controlled freehand vs. computer-navigated drilling in the sacrum—a cadaveric study by Lukas Kleiner, Nicole Wolf, Christina Precht, Kati Haenssgen, Franck Forterre, Pia Düver

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ESTRO guidelines for developing questionnaires in survey-based radiation oncology research by Amanda Webster, Lotte S. Fog, Emma Hall, Peter S.N. van Rossum, Daan Nevens, Pierre Montay-Gruel, Pierfrancesco Franco, Elizabeth Joyce, Nuria Jornet, Catharine H. Clark, Jenny Bertholet

“…Dissemination strategies are highlighted to maximize response rates and enhance data completeness across diverse clinical, research and industrial settings. Rigorous analysis techniques are discussed to uncover insights that optimize operational efficiencies and inform evidence-based practices. …”
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Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels by Jeong Min Song, Ala Aiob, Ala Aiob, Kidong Kim, Kidong Kim, Kwang Beom Lee, Sokbom Kang, Chae Hyeong Lee, Se Ik Kim, Nam Kyeong Kim, Dae Hoon Jeong

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Paracetamol did not improve the analgesic efficacy with regional block after video assisted thoracoscopic surgery: a randomized controlled trial by Sujin Kim, Seung Woo Song, Haesung Lee, Chun Sung Byun, Ji-Hyoung Park

“…Trial registration this trial was registered on Clinical Research Information Service (CRIS), Republic of Korea (KCT0008710). …”
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Research progress of Traditional Chinese Medicine nursing techniques for cough symptoms of lung cancer patients (中医护理技术改善肺癌患者咳嗽症状的研究进展) by HOU Yanli (侯燕丽), ZHANG Ying (张英), LIN Haiqing (林海青), CHEN Mengna (陈梦娜), CHEN Yang (陈扬)

“…The four most commonly used Traditional Chinese Medicine nursing techniques were summarized as acupoint application, moxibustion, acupoint injection and Chinese herbal medicine ointment rubbing, and the existing problems in clinical research were analyzed, aiming at improving the standard clinical application and research of TCM nursing techniques for lung cancer patients with cough symptoms. …”
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Observational research in epidemic settings: a roadmap to reform by Marc Lipsitch, Nicholas Evans, Alexandra L Phelan, Stephany N Duda, Annette Rid, Colin J Carlson, Jennifer B Rosen, Natalie E Dean, John Barugahare, Maya B Mathur, Emily E Ricotta, Fausto A Bustos Carrillo, Samuel Angelli-Nichols, Adia Benton, Emma Chang-Rabley, Lisa Federer, Mary-Margaret A Fill, Elizabeth C LeRoy, Natalie M Linton, Lauren Sauer, Sheena G Sullivan, Mackenzie Zendt

“…Observational studies are critical tools in clinical research and public health response, but challenges arise in ensuring the data produced by these studies are scientifically robust and socially valuable. …”
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

“…The translation of animal-based biomedical research into clinical research is often inadequate. Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. …”
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