Improving the Military Vocational Training of Cadets at Military Institute by Yu. G. Bychenko, T. M. Balandina

“…Military institutions are traditionally focused on the implementation of the classical, narrow form of educational development of professional knowledge and skills of cadets. …”
Get full text

சிந்தனைத் தளத்தில் சுகுமாரனின் வண்டு குண்டு / Thoughts in Sukumaran's Vandu Kundu by முனைவர் ந. இரஞ்சன் / Dr. N. Ranjan

“…In the field of Tamil literature, most classical and modern works focus on men and women with limited references to boys during the Sangam period. …”
Get full text

Interdisciplinary participation in climate-adapted urban land-use planning – findings of two gaming simulations in the city of Bottrop, Germany by Marisa Fuchs, Madeleine Loren Kirstein

“…Participation in formal urban land-use planning procedures is classically linear and multidisciplinary in Germany. …”
Get full text

Role of sirtuins in epigenetic regulation and aging control by E. M. Samoilova, S. E. Romanov, D.  A. Chudakova, P. P. Laktionov

“…As is expected, the activity of sirtuin proteins affects the manifestation of classic signs of aging in the body, such as cellular senescence, metabolic disorders, mitochondrial dysfunction, genomic instability, and the disruption of epigenetic regulation. …”
Get full text

Geodesic Distance on Gaussian Manifolds to Reduce the Statistical Errors in the Investigation of Complex Systems by Michele Lungaroni, Andrea Murari, Emmanuele Peluso, Pasqualino Gaudio, Michela Gelfusa

“…In particular, since some time it has emerged quite clearly that even slightly departures from normality and homoscedasticity can affect significantly classic significance tests. Robust statistical methods have been developed, which can provide much more reliable estimates. …”
Get full text

Rapid assessment of main agronomic indicators in the grain of winter and spring forms of triticale using infrared spectroscopy by V. S. Popov, N. G. Konkova, T. V. Shelenga, V. I. Khoreva, I. A. Kibkalo, M. Kh. Gadjimagomedova, L. G. Suvaryan

“…Calibration models for the assessment of the said agronomic characters in triticale grain were developed on the platform of the MATRIX-I IR analyzer (Bruker Optics, Germany) and based on the values obtained by classical methods of biochemical analysis adopted at VIR. …”
Get full text

Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…There was a strong correlation between reduction of plasma levels of FB and alternative complement pathway activity (AH50), but no meaningful changes in classical complement pathway activity (CH50). The long duration of lowering of FB levels following the last dose supports monthly dosing in future clinical trials. …”
Get full text

The Ischial Spine in Developmental Hip Dysplasia: Unraveling the Role of Acetabular Retroversion in Periacetabular Osteotomy by Gerard El-Hajj, Hicham Abdel-Nour, Rami Ayoubi, Joseph Maalouly, Fouad Jabbour, Raja Ashou, Alexandre Nehme

“…In a previous paper, we reported the classic coxometric measurements of 178 patients with symptomatic hip dysplasia undergoing PAO where retroversion was noted in 42% of the cases and was not found to be a major factor in the appearance of symptoms. …”
Get full text

Physics-Based Compact Model of Independent Dual-Gate BEOL-Transistors for Reliable Capacitorless Memory by Lihua Xu, Kaifei Chen, Zhi Li, Yue Zhao, Lingfei Wang, Ling Li

“…Capacitorless DRAM architectures based on Back-End-of-Line (BEOL)-transistors are promising for long-retention, high-density and low-power 3D DRAM solutions due to its low leakage, operational flexibility, and monolithic integration capability. Different from classical silicon-based devices, in-depth studies on the performances of nanoscale multi-gate transistors (e.g., a-InGaZnO-FET) are still barely conducted for physical description, due to the complicated multi-gating principle, finite-size effects on transport, increased variation sources and enlarged parasitic effect. …”
Get full text

Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation by Eriko Nakano, Kosuke Mukai, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura, Takamasa Ichijo, Mika Tsuiki, Norio Wada, Takashi Yoneda, Yoshiyu Takeda, Kenji Oki, Tetsuya Yamada, Yoshihiro Ogawa, Daisuke Yabe, Miki Kakutani, Masakatsu Sone, Takuyuki Katabami, Akiyo Tanabe, Mitsuhide Naruse, JPAS/JRAS Study Group

“…Logistic regression analysis demonstrated that the ΔPAC (the difference between the PAC measurements before and after ACTH stimulation) significantly increased the odds of previous CCV events in PA patients after adjusting for classical CCV event risk factors, baseline PAC and duration of hypertension (relative PAC: odds ratio [OR], 2.896; 95% confidence interval [CI], 0.989–8.482; ΔPAC: OR, 2.344; 95% CI, 1.149–4.780; ACTH-stimulated PAC: OR, 2.098; 95% CI, 0.694–6.339). …”
Get full text

Delayed Graft Function in Kidney Transplants: Time Evolution, Role of Acute Rejection, Risk Factors, and Impact on Patient and Graft Outcome by Martin Chaumont, Judith Racapé, Nilufer Broeders, Fadoua El Mountahi, Annick Massart, Thomas Baudoux, Jean-Michel Hougardy, Dimitri Mikhalsky, Anwar Hamade, Alain Le Moine, Daniel Abramowicz, Pierre Vereerstraeten

“…From 1983 to 2014, 1784 kidney-only transplantations from deceased donors were studied. Classical risk factors for DGF along with two novel ones, recipient’s perioperative saline loading and residual diuresis, were analyzed by logistic regression and receiver operating characteristic (ROC) curves. …”
Get full text

Ecological network construction and optimization of typical resource-based regions, and strategies for the enhancement of multiple ecosystem services: Balancing function and struct... by Shaoqing Wang, Yanling Zhao, Qiyuan Wang, He Ren, Shichao Zhu, Jiarui Cao

“…However, the application of the classic method of ENs construction in large-scale resource mining areas is not ideal. …”
Get full text

Neethling Strain-Based Homologous Live Attenuated LSDV Vaccines Provide Protection Against Infection with a Clade 2.5 Recombinant LSDV Strain by Wannes Philips, Andy Haegeman, Nina Krešić, Laurent Mostin, Nick De Regge

“…Background: Vaccination is the main control measure to prevent Lumpy skin disease (LSD), and Neethling-based homologous vaccines have been shown to be safe and effective against infection with classical clade 1.2 strains. In 2017, recombinant clade 2 LSDV strains originating from a badly produced and insufficiently controlled vaccine were first detected in Russia. …”
Get full text

Transcriptional and Posttranscriptional Regulations of the HLA-G Gene by Erick C. Castelli, Luciana C. Veiga-Castelli, Layale Yaghi, Philippe Moreau, Eduardo A. Donadi

“…The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-γ and NF-κB, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident. …”
Get full text

Allelic and epigenetic DNA variation in relation to F1 heterosis manifestation in F1 hybrids of Capsicum annuum L. by M. N. Shapturenko, S. V. Vakula, L. A. Tarutina, T. V. Nikitinskaya, T. V. Pechkovskaya, L. A. Mishin, L. V. Khotyleva

“…Managing F1 heterosis is one of the major objectives in hybrid crop breeding programs. The classical theory considers the heterozygosity in F1 hybrids to be the main factor contributing to heterosis and therefore presumes a linear relationship between the value of genetic polymorphisms in parental lines and the heterotic response of their F1 offspring. …”
Get full text

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

“…Therefore, the effect of a cardiomyocyte-specific Hif-1a knockout (cHif1aKO) was studied in an established α-MHC719/+ HCM mouse model that exhibits the classical features of human HCM. The results show that Hif-1α protein and HIF targets were upregulated in left ventricular tissue of α-MHC719/+ mice. …”
Get full text

Classification of Periodic Variable Stars from TESS by Xinyi Gao, Xiaodian Chen, Shu Wang, Jifeng Liu

“…Pulsating variable stars and eclipsing binaries are distinguished mainly by period, LC parameters, and physical parameters. Classical Cepheids, Type-II Cepheids, rotational variable stars, eruptive variable stars of the UV Ceti type, and young stellar objects are distinguished mainly by period and physical parameters. …”
Get full text

A case of hypophysitis after COVID-19 vaccination with a detection of anti-pituitary antibody, with review of literature by Chika Kyo, Tomoko Kobayashi, Shintaro Iwama, Rieko Kosugi, Fumikazu Sawabe, Ryo Hayafusa, Yuki Sakai, Tatsuo Ogawa, Masato Kotani, Tatsuhide Inoue, Hiroshi Arima, Hiroyuki Ariyasu

“…Symptoms of hypophysitis after COVID-19 vaccination are similar to those of classic pituitary dysfunction. Pituitary insufficiency is persistent, with five of the above eight patients presenting posterior pituitary dysfunction and three patients presenting only anterior pituitary dysfunction. …”
Get full text

Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…While third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the cornerstone of frontline therapy for patients harboring classic sensitive EGFR mutations, all tumors ultimately develop acquired resistance to these approaches, which can be categorized into three primary mechanism subclasses. …”
Get full text

A Subclass of Gamma-Ray Burst Originating from Compact Binary Merger by Chen-Wei Wang, Wen-Jun Tan, Shao-Lin Xiong, Shu-Xu Yi, Rahim Moradi, Bing Li, Zhen Zhang, Yu Wang, Yan-Zhi Meng, Bo-Bing Wu, Jia-Cong Liu, Yue Wang, Sheng-Lun Xie, Wang-Chen Xue, Zheng-Hang Yu, Peng Zhang, Wen-Long Zhang, Yan-Qiu Zhang, Chao Zheng

“…Since they show strikingly similar properties (indicating a common mechanism), which are different from the classic “long”-short burst (e.g., GRB 060614), we find they form an interesting subclass of type I GRBs, and we suggest to name them as type IL GRB. …”
Get full text