PRPF3-Associated Autosomal Dominant Retinitis Pigmentosa and CYP4V2-Associated Bietti’s Crystalline Corneoretinal Dystrophy Coexist in a Multigenerational Chinese Family by Xiaohong Meng, Qiyou Li, Hong Guo, Haiwei Xu, Shiying Li, Zhengqin Yin

“…One missense mutation (c.1482C>T, p.T494M) in the PRPF3 gene was detected in 9 out of 22 affected family members who manifested classical clinical features of RP. Conclusions. Our results showed that two compound heterozygous CYP4V2 mutations caused BCD, and one missense mutation in PRPF3 was responsible for adRP in this large family. …”
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MSC-derived exosome ameliorates pulmonary fibrosis by modulating NOD 1/NLRP3-mediated epithelial-mesenchymal transition and inflammation by Wei Chen, Jie Peng, Xiangyi Tang, Shao Ouyang

“…Using cell counting kit-8 (CCK-8) to detect cell viability. Classic molecular biology approaches such as RT-qPCR, Western blot, immunofluorescence, and ELISA were used to examine molecular pathways. …”
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The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…This review focused on SUMOylation in tumor cells to discuss its effects on tumor suppressor proteins and oncoproteins as well as classical tumor pathways to identify new insights for cancer clinical therapy.…”
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Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching by Yuyang Sun, Jiqing Tang, Cui Li, Jun Liu, Haijie Liu

“…Of note, sulforaphane skewed the switching from classically (M1) to alternatively (M2) activated phenotype both in intestinal and bone marrow-derived macrophages (BMDMs). …”
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An improved fuzzy time series forecasting model based on hesitant fuzzy sets by Lubna Shafi, Shilpi Jain, Praveen Agarwal, Pervaiz Iqbal, Aadil Rashid Sheergojri

“…The Hesitant Fuzzy Set (HFS) theory better emphasizes the chances of capturing fuzziness and uncertainty due to randomness than the classic fuzzy set theory. This study aims to improve the previously identified hesitant fuzzy TSF models by including various degrees of hesitation to improve forecasting performance. …”
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The DOA Estimation Algorithm Based on Virtual Domain Block Matching for Nested Arrays in the Presence of Mutual Coupling by Shun He, Nan Sun, Zhiwei Yang, Le Qin

“…The algorithm begins by partitioning the mutual coupling matrix of nested arrays, then applies a classical separation method used in Uniform Linear Array to obtain the separation parameters. …”
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An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of Bordetella pertussis by Alexandre D’Halluin, Denisa Petráčková, Ivana Čurnová, Jakub Držmíšek, Jan Čapek, Peggy Bouquet, Loïc Henin, Rudy Antoine, Loïc Coutte, Camille Locht, Branislav Večerek, David Hot

“…Here, we describe the regulatory RNA Rfi2, which is transcribed from the Pout promoter of the IS481 gene BP1118 antisense to the adjacent fim2 gene encoding the major serotype 2 fimbrial subunit of B. pertussis. Among the classical bordetellae, Rfi2 is unique to B. pertussis, suggesting its specific role in virulence. …”
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Spectral multiplier theorems for abstract harmonic oscillators on UMD lattices by van Neerven, Jan, Portal, Pierre, Sharma, Himani

“…We prove functional calculus results for these abstract harmonic oscillators that match classical Hörmander spectral multiplier estimates for the harmonic oscillator $-\frac{1}{2}\Delta + \frac{1}{2}|x|^{2}$ on $L^{p}(\mathbb{R}^{d})$. …”
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Urdu Handwritten Characters Data Visualization and Recognition Using Distributed Stochastic Neighborhood Embedding and Deep Network by Mujtaba Husnain, Malik Muhammad Saad Missen, Shahzad Mumtaz, Dost Muhammad Khan, Mickäel Coustaty, Muhammad Muzzamil Luqman, Jean-Marc Ogier, Hizbullah Khattak, Sikandar Ali, Ali Samad

“…We performed three tasks in a disciplined order; namely, (i) we generated a state-of-the-art dataset of both the Urdu handwritten characters and numerals by inviting a number of native Urdu participants from different social and academic groups, since there is no publicly available dataset of such type till date, then (ii) applied classical approaches of dimensionality reduction and data visualization like Principal Component Analysis (PCA), Autoencoders (AE) in comparison with t-Stochastic Neighborhood Embedding (t-SNE), and (iii) used the reduced dimensions obtained through PCA, AE, and t-SNE for recognition of Urdu handwritten characters and numerals using a deep network like Convolution Neural Network (CNN). …”
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Telecommand Rejection Probability in CCSDS-Compliant LDPC-Coded Space Transmissions With Tail Sequence by Rebecca Giuliani, Massimo Battaglioni, Marco Baldi, Franco Chiaraluce, Nicola Maturo

“…A low-complexity approach classically used to detect CLTU termination is to choose a non-correctable string as the tail sequence, and then exploit the decoder failure on that sequence as termination detection. …”
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Functional Involvement of Melatonin and Its Receptors in Reproductive Regulation of the Marine Teleost, Large Yellow Croaker (<i>Larimichthys crocea</i>) by Xudong Liang, Jixiu Wang, Baoyi Huang, Haojie Yuan, Yucheng Ren, Chenqian Wu, Tianming Wang, Jingwen Yang

“…Enzyme- linked immunosorbent assay (ELISA) results further demonstrated that in vitro melatonin incubation in the brain of <i>L. crocea</i> influenced gonadotropin-releasing hormone (GnRH) and testosterone secretion in a dose-dependent manner, suggesting actions beyond the classical hypothalamic–pituitary–gonadal (HPG) axis. …”
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SensorDBSCAN: Semi-Supervised Active Learning Powered Method for Anomaly Detection and Diagnosis by Petr Ivanov, Maria Shtark, Alexander Kozhevnikov, Maksim Golyadkin, Dmitry Botov, Ilya Makarov

“…The proposed approach combines a transformer-based encoder trained with a triplet-based contrastive learning objective and the classical density-based clustering algorithm DBSCAN, enabling strong feature extraction, efficient and interpretable feature space organization and simple clustering algorithm. …”
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Determination of the degree of sulfonation in cross-linked and non-cross-linked Poly(ether ether ketone) using different analytical techniques by Abdul G. Al Lafi, Mohammed S. Rihawy, Abdul W. Allaf, Ali Alzier, Reem Hasan

“…Both non-cross-linked and cross-linked SPEEK were examined to assess the advantages and limitations of these methods. Classical approaches, such as titration and back titration are suitable for all sulfonated samples; however, they are limited by challenges like the extended time required for neutralization reaction due to hydrogen bonding between sulfonic acid groups. …”
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Mesenchymal stem cells-derived exosomes attenuate mouse non-heart-beating liver transplantation through Mir-17-5p-regulated Kupffer cell pyroptosis by Yang Tian, Ming Jin, Nanwei Ye, Zhenzhen Gao, Yuancong Jiang, Sheng Yan

“…This action inhibited NLRP3-mediated pyroptosis of Kupffer cells through the classical Caspase1-dependent pathway, alleviating DCD liver graft injury. …”
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Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study by Huiping Li, Shu Liu, Caimei Lin, Yuchao Wu, Xiuping Wu, Yukun Huang, Yajun Wu, Xiubin Tong, Xiu Xu

“…This was a prospective, single-arm, single-site, open-label, early phase 1 pilot study. Three girls with classic RTT aged 5–10 years were enrolled. Esketamine was intravenously administrated once per week for 5 weeks. …”
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Complete Genome Sequence of the Plant Growth-Promoting Bacterium Hartmannibacter diazotrophicus Strain E19T by Christian Suarez, Stefan Ratering, Torsten Hain, Moritz Fritzenwanker, Alexander Goesmann, Jochen Blom, Trinad Chakraborty, Boyke Bunk, Cathrin Spröer, Jörg Overmann, Sylvia Schnell

“…Interestingly, no genes classically reported to encode for ACC deaminase activity are present. …”
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Approximate Solutions of Combinatorial Problems via Quantum Relaxations by Bryce Fuller, Charles Hadfield, Jennifer R. Glick, Takashi Imamichi, Toshinari Itoko, J. Richard Thompson, Yang Jiao, M. Marna Kagele, W. Blom-Schieber Adriana, Rudy Raymond, Antonio Mezzacapo

“…It produces average cuts that approximate the optimal one by a factor of least 0.555 or 0.625, depending on the relaxation chosen, if given access to a quantum state with energy between the optimal classical cut and the maximal relaxed energy. The second rounding protocol is deterministic and is based on the estimation of Pauli observables. …”
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A Multistage Detection Framework Based on TFA and Multiframe Correlation for HFSWR by Zongtai Li, Gangsheng Li, Ling Zhang, Lanjun Liu, Q. M. Jonathan Wu

“…Comparative analysis against classical target detection algorithms demonstrates the superior detection performance of the proposed framework within clutter regions. …”
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RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Furthermore, depletion of PARP1 or RECQL4 substantially impacted classical-NHEJ- and alternative-NHEJ-mediated DSB repair. …”
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Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy by Run‐Wei Song, Tian‐Ci Jiang, Xue‐Yang Zhang, Cheng‐Long Shen, Qing Lou, Chong‐Xin Shan

“…Abstract In classical photodynamic therapy, tumor cells are killed by the cytotoxic species via type‐I/II photochemical reactions, seriously limited by the external photoexcitation and hypoxia. …”
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