CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers by Chiara Tuccilli, Enke Baldini, Salvatore Sorrenti, Antonio Catania, Alessandro Antonelli, Poupak Fallahi, Francesco Tartaglia, Susi Barollo, Caterina Mian, Andrea Palmieri, Giovanni Carbotta, Stefano Arcieri, Daniele Pironi, Massimo Vergine, Massimo Monti, Salvatore Ulisse

“…Higher expression of PD-L1 associated with the classical histological variant and with the presence of BRAFV600E mutation in PTC. …”
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Phase separation of a microtubule plus-end tracking protein into a fluid fractal network by Mateusz P. Czub, Federico Uliana, Tarik Grubić, Celestino Padeste, Kathryn A. Rosowski, Charlotta Lorenz, Eric R. Dufresne, Andreas Menzel, Ioannis Vakonakis, Urs Gasser, Michel O. Steinmetz

“…This process is accompanied by conformational rearrangements in Bik1, leading to at least a two-fold increase in multivalent interactions between its folded and disordered domains. Unlike classical liquids, Bik1 condensates exhibit a heterogeneous, fractal supramolecular structure with protein- and solvent-rich regions. …”
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Hiatal Hernia Repair with Gore Bio-A Tissue Reinforcement: Our Experience by Agrusa Antonino, Romano Giorgio, Frazzetta Giuseppe, De Vita Giovanni, Di Giovanni Silvia, Chianetta Daniela, Di Buono Giuseppe, Sorce Vincenzo, Gulotta Gaspare

“…We present a case of a 65-year-old female patient with a 6-year classic history of GERD. Endoscopy revealed a large hiatal hernia and esophagitis. pH study was positive for acid reflux; esophageal manometry revealed LES intrathoracic dislocation. …”
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Optimal Partitioning of Quantum Circuits Using Gate Cuts and Wire Cuts by Sebastian Brandhofer, Ilia Polian, Kevin Krsulich

“…Quantum circuit partitioning divides a quantum computation into classical postprocessing steps and a set of smaller scale quantum computations that individually require fewer qubits, lower qubit connectivity, and typically incur less error. …”
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Modeling and Identification of Electromagnetic Actuator for the Control of Rotating Machinery by T.S. Morais, J. Der Hagopian, V. Steffen Jr., J. Mahfoud

“…First the EMAs were modeled by using classical equations of electromagnetism and then identified experimentally. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…Some of these effects occur when PPARγ is pharmaceutically antagonized or genetically PPARγ and are thus independent of classical PPARγ-dependent transcriptional control. …”
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A Unique Case of Primary Ewing’s Sarcoma of the Cervical Spine in a 53-Year-Old Male: A Case Report and Review of the Literature by Marshall T. Holland, Oliver E. Flouty, Liesl N. Close, Chandan G. Reddy, Matthew A. Howard

“…These rapidly growing tumors often present with focal neurological symptoms of myelopathy or radiculopathy. There are no classic characteristic imaging findings and thus the physician must keep a high index of clinical suspicion. …”
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Implementation and Comparison of High-Resolution Spatial Discretization Schemes for Solving Two-Fluid Seven-Equation Two-Pressure Model by Pan Wu, Fei Chao, Dan Wu, Jianqiang Shan, Junli Gou

“…As compared to the two-fluid single-pressure model, the two-fluid seven-equation two-pressure model has been proved to be unconditionally well-posed in all situations, thus existing with a wide range of industrial applications. The classical 1st-order upwind scheme is widely used in existing nuclear system analysis codes such as RELAP5, CATHARE, and TRACE. …”
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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats by Manman Li, Nange Ma, Shujie Luo, Yuyi Lu, Xixi Yan, Yang Li, Xinmei Li, Zhuohui Li, Zhipei Wu, Zhenyu Wei, Wei Wang, Huimei Fan, Yu Jiang, Yan Xiong, Yu Wang

“…Results Our histological studies and bulk transcriptome gene expression analysis confirmed that both perirenal and omental adipose tissues (pAT and oAT) exhibited progressive whitening in goats. Compared to the classic brown adipocytes in mice, goat thermogenic adipocytes were more closely related in gene expression patterns to human beige adipocytes, which was also confirmed by adipocyte type- and lineage-specific marker expression analysis. …”
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Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis by Wenhui Qian, Bei Zhang, Ming Gao, Yuting Wang, Jiachen Shen, Dongbing Liang, Chao Wang, Wei Wei, Xing Pan, Qiuying Yan, Dongdong Sun, Dong Zhu, Haibo Cheng

“…Huanglian-Wumei decoction (HLWMD) is a classic prescription used for treating inflammatory diseases, but the necessity of their combination and the exact underlying anti-inflammatory mechanism have not yet been elucidated. …”
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The follow-up of patients with celiac disease by Marco Di Tola, Hetty J. Bontkes, Juan Irure-Ventura, Marcos López-Hoyos, Nicola Bizzaro

“…The aim of this report was to evaluate the classical tools used to monitor the adherence and response to GFD, other non-invasive biomarkers that have been proposed for CD monitoring, and the histological follow-up of CD patients in order to provide a starting point for future discussions on this specific topic.…”
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Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach by Siti Junaidah Ahmad, Mohd Badrin Hanizam Abdul Rahim, Syarul Nataqain Baharum, Mohd Shukri Baba, Noraziah Mohamad Zin

“…Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. …”
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Mean Platelet Volume in Ocular Behçet’s Disease by Fatih Mehmet Türkcü, Abdullah Kürşat Cingü, Harun Yüksel, Yasin Çınar, Meltem Akkurt, Muhammed Şahin, Zeynep Özkurt, Alparslan Şahin, İhsan Çaça

“…MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment.…”
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A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain by Wen-Juan Han, Lei Chen, Hai-Bo Wang, Xiang-Zeng Liu, San-Jue Hu, Xiao-Li Sun, Ceng Luo

“…This analgesic potency was more potent than that produced by classical NSAIDs aspirin and traditional nitroxide radical Tempol alone. …”
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Mathematical analysis of a model for HIV-malaria co-infection by Zindoga Mukandavire, Abba B. Gumel, Winston Garira, Jean Michel Tchuenche

“…Thus, for malaria, the classical requirementof having the associated reproduction number to be less than unity,although necessary, is not sufficient for its elimination. …”
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Personalized Federated Learning for Heterogeneous Residential Load Forecasting by Xiaodong Qu, Chengcheng Guan, Gang Xie, Zhiyi Tian, Keshav Sood, Chaoli Sun, Lei Cui

“…Deep learning (DL) model has replaced other classical models as the most popular prediction models. …”
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Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients by Natalia Maximova, Marilena Granzotto, Francesca Barbieri, Annalisa Marcuzzi, Alberto Tommasini, Lorenzo Monasta, Roberto Simeone, Davide Zanon, Roberto Sala

“…In addition, patients undergoing prophylaxis with defibrotide had “classical” engraftment, a common cytokine profile and a lower incidence of life‐threatening transplant‐related complications. …”
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Performance of Quantum Annealing Machine Learning Classification Models on ADMET Datasets by Hadi Salloum, Kamil Sabbagh, Vladislav Savchuk, Ruslan Lukin, Osama Orabi, Marat Isangulov, Manuel Mazzara

“…We compare QAML with classical machine learning to evaluate their relative performance. …”
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Glycyrrhizic Acid Promotes M1 Macrophage Polarization in Murine Bone Marrow-Derived Macrophages Associated with the Activation of JNK and NF-κB by Yulong Mao, Baikui Wang, Xin Xu, Wei Du, Weifen Li, Youming Wang

“…Meanwhile, GA upregulated the expression of CCR7 and the production of TNF-α, IL-12, IL-6, and NO (the markers of classically activated (M1) macrophages), whereas it downregulated the expression of MR, Ym1, and Arg1 (the markers of alternatively activated (M2) macrophage). …”
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Computer‐Aided High Tibial Osteotomy—A Comparative Study of Commonly Used 3D Printing Technology and Navigation Application by Elvis Chun‐Sing Chui, Kyle Ka‐Kwan Mak, Randy Hin‐Ting Ng, Ericsson Chun‐Hai Fung, Mei‐Shuen Chan, Kai Yue, Lawrence Chun‐Man Lau, Clifford Long‐Fung Chan, Edmond Wing‐Fung Yau, Wei Zhao, Xiuyun Su, Jin Zhang, Jianglong Xu, Hongxun Sang, Guoxian Pei, Louis Wing‐Hoi Cheung, Sheung‐Wai Law, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung

“…Results The results showed that the metal surgical guides had the highest accuracy (angle differences mean, 2.4°) and operation time (mean 9.75 min), followed by plastic guides, classic guides, and the navigation system. The differences in accuracy were attributed to factors like rigidity, melting point, and errors during incisions. …”
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