Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

Subjects: “…Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS)…”
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A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

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Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatric myalgic encephalomyelitis/chronic fatigue syndrome in Australian adolescents aged 12–19 years by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling condition that can affect adolescents during a vulnerable period of development. …”
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« Mauvaise fatigue » et contrôle de soi : une approche sociohistorique by Marc Loriol

“…New pathological categories emerged, ranging from acedia to chronic fatigue syndrome, to give a socially recognized meaning to this new form of fatigue experienced by individuals who found it difficult to adapt to the new requirements, and often to convey a sense of normality. …”
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Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection by Shixing Tang, Indira K. Hewlett

“…Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in 2010, several test methods including nucleic acid testing methods and serological assays have been developed for detection of XMRV and/or MLV-like sequences. …”
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Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients by Krista A. Delviks-Frankenberry, Chawaree Chaipan, Rachel Bagni, Kathleen Wyvill, Robert Yarchoan, Vinay K. Pathak

“…Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus reported to be associated with human prostate cancer and chronic fatigue syndrome. Since retroviruses cause various cancers, and XMRV replication might be facilitated by HIV-1 co-infection, we asked whether certain patients with HIV-associated lymphomas are infected with XMRV. …”
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Fatigue Status in Relation to Lifestyle in Healthy Japanese Adolescents by Ning Zou, Masaru Kubota, Eriko Kuruma, Chiaki Kojima, Ayako Nagai

“…In order to investigate the prevalence of physical, mental, and chronic fatigue syndrome-(CFS-) related fatigue and its relation to lifestyle, 1,225 adolescents (591 males, 634 females) aged 11 to 16 years were asked to complete a self-reported questionnaire on fatigue status and lifestyle in the past one month. …”
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XMRV Discovery and Prostate Cancer-Related Research by David E. Kang, Michael C. Lee, Jaydip Das Gupta, Eric A. Klein, Robert H. Silverman

“…Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. …”
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Crohn’s disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management—a case report by Johannes Haedrich, Roman Huber

“…Conclusions This case report exemplifies the interrelation between organic (Crohn’s disease) and functional diseases (irritable bowel syndrome, chronic fatigue syndrome, and somatoform pain). It further demonstrates that these connections may be overlooked in daily practice and that providing a plausible explanation in combination with symptom relief may be important for patients with functional syndromes.…”
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Machine learning and multi-omics in precision medicine for ME/CFS by Katherine Huang, Brett A. Lidbury, Natalie Thomas, Paul R. Gooley, Christopher W. Armstrong

“…Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and multifaceted disorder that defies simplistic characterisation. …”
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A Comparison of Dysautonomias Comorbid with Cyclic Vomiting Syndrome and with Migraine by Gisela Chelimsky, Shruti Madan, Amer Alshekhlee, Elizabeth Heller, Kevin McNeeley, Thomas Chelimsky

“…Cross-sectional study of patients utilizing the ODYSA instrument, evaluating the probability of 12 functional/autonomic diagnoses, CVS, migraine, orthostatic intolerance (OI), reflex syncope, interstitial cystitis, Raynaud's syndrome, complex regional pain syndrome (CRPS), irritable bowel syndrome, functional dyspepsia, functional abdominal pain, fibromyalgia, and chronic fatigue syndrome. Control subjects were age-matched gender-matched friends. …”
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Theoretical Accounts of Gulf War Syndrome: From Environmental Toxins to Psychoneuroimmunology and Neurodegeneration by Eamonn Ferguson, Helen J. Cassaday

“…This paper reviews evidence suggesting that such symptoms can be explained more parsimoniously as a single symptom cluster than as a set of separate illnesses such as Gulf War Syndrome (GWS) and chronic fatigue syndrome (CFS). This superordinate syndrome could have its biological basis in the activity of pro-inflammatory cytokines (in particular interleukin-1: IL-1), that give rise to what has become known as the ‘sickness response’. …”
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Cerebral Blood Flow in Orthostatic Intolerance by Muhammad Shahzeb Khan, Amanda J. Miller, Arooba Ejaz, Jeroen Molinger, Parag Goyal, David B. MacLeod, Ashley Swavely, Elyse Wilson, Meghan Pergola, Harikrishna Tandri, Camille Frazier Mills, Satish R Raj, Marat Fudim

“…However, in many other OI syndromes such as myalgic encephalomyelitis/chronic fatigue syndrome and long COVID, heart rate and blood pressure are frequently normal despite significant drops in CBF. …”
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How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies by Agata Sebastian, Maciej Sebastian, Maria Misterska-Skóra, Patryk Woytala, Katarzyna Jakuszko, Piotr Wiland

“…In conclusion, invasive methods are pivotal in pSS diagnosis in this salivary gland biopsy. Chronic fatigue syndrome is more common in pSS patients and can be subjective distinguishing factor in the group of people with dryness.…”
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Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals by J Sardell, S Das, K Taylor, C Stubberfield, A Malinowski, M Strivens, S Gardner

“…We exemplify this by identifying individuals who remain healthy despite possessing several disease signatures associated with increased risk of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or amyotrophic lateral sclerosis (ALS). …”
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A Novel Nomogram for Early Identification of CFS-Like Symptoms in University Students with Infectious Mononucleosis by Deping Sun, Yanan Liang, Fuwei Yang, Lan Liu, Yuqin Yan

“…This study aims to develop and evaluate a nomogram for predicting the risk of chronic fatigue syndrome (CFS)-like symptoms in university students diagnosed with infectious mononucleosis (IM), using clinical characteristics and laboratory findings as predictive variables. …”
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Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples by M. F. Kearney, K. Lee, R. K. Bagni, A. Wiegand, J. Spindler, F. Maldarelli, P. A. Pinto, W. M. Linehan, C. D. Vocke, K. A. Delviks-Frankenberry, R. W. deVere White, G. Q. Del Prete, J. W. Mellors, J. D. Lifson, V. N. KewalRamani, V. K. Pathak, J. M. Coffin, S. F. J. Le Grice

“…The MLV-related retrovirus, XMRV, was recently identified and reported to be associated with both prostate cancer and chronic fatigue syndrome. At the National Cancer Institute-Frederick, MD (NCI-Frederick), we developed highly sensitive methods to detect XMRV nucleic acids, antibodies, and replication competent virus. …”
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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…Cognitive impairment is one of the many symptoms reported by individuals suffering from long-COVID and other post-viral infection disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A common factor among these conditions is a sustained immune response and increased levels of inflammatory cytokines. …”
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