NCK2 Is Significantly Associated with Opiates Addiction in African-Origin Men by Zhifa Liu, Xiaobo Guo, Yuan Jiang, Heping Zhang

“…By employing both SNP- and gene-based methods of analysis, we identified a strong (odds ratio = 13.87) and significant (P value = 1.33E−11) association of an SNP in the NCK2 gene on chromosome 2 with opiates addiction in African-origin men. …”
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Evaluation of Possible Genotoxic Activity of Dirithromycin in Cultured Human Lymphocytes by Ahmet Kayraldız, Lale Dönbak, Ayşe Yavuz Kocaman, Esra Köker, Şule Gökçe

“…In the present study, the possible genotoxicity of dirithromycin was evaluated in cultured human lymphocytes by using sister chromatid exchanges (SCEs), chromosome aberration (CA), and micronucleus (MN) tests and also cell proliferation kinetics such as mitotic index (MI), replication index (RI), and nuclear division index (NDI) were analyzed for cytotoxicity. …”
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Elevated Aminotransferase Activity as an Indication of Muscular Dystrophy: Case Reports and Review of the Literature by S Zamora, C Adams, JD Butzner, H Machida, Rb Scott

“…All five were later diagnosed with X chromosome-linked muscular dystrophy. The serum level of ALT, generally considered to be specific for hepatocellular injury, was increased two to 25 times above normal in all the reported cases. …”
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Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition by Sun Ah Kim, Yun Joo Yoo

“…We used several experimental datasets obtained by sampling subsets of single nucleotide polymorphism (SNP) markers of chromosome 22 region in the 1000 Genomes Project data and also the HapMap phase 3 data to compare the results of haplotype block partitions by five methods. …”
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Microduplication of 3p26.3 Implicated in Cognitive Development by Leah Te Weehi, Raj Maikoo, Adrian Mc Cormack, Roberto Mazzaschi, Fern Ashton, Liangtao Zhang, Alice M. George, Donald R. Love

“…Several deletions, one translocation, and one duplication have previously been described in this region of chromosome 3. The CHL1 gene has been proposed as a dosage-sensitive gene with a central role in cognitive development, and so the microduplication reported here appears to be implicated in our patient’s phenotype.…”
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Screening and marker trait association for salinity tolerance in rice (Oryza sativa L.) by P. Hima Bindu1*, G. Shiva Prasad2, R.M. Sundaram3, K. Sumalini1 and C.H. Damodar Raju4

“…Nine of the 16 polymorphic markers RM3412, RM10843, RM562, RM10793, RM 10748, RM8094, RM10694, RM1287 and RM493 showed statistically significant marker-trait relationships, suggesting the presence of important putative genetic loci linked to chromosome 1 with ability to withstand salinity. The range of 1.0% to 24.9% for the percentage of total variance of phenotype explained by the relevant markers indicates the dependability of these genetic markers for enhancing breeding for salinity tolerance. …”
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Determination of mutagenicity of chemical compounds, physical factors and environmental pollutants by the Drosophila melanogaster wing somatic mutation and recombination test by L. P. Zakharenko, I. K. Zakharov

“…The mutations, multi wing hairs (mwh; 3 – 0.3) and flare (flr; 3 – 38.8), are located on the left arm of chromosome 3. The Drosophila melanogaster wing contains 24,400 cells arranged in two layers. …”
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Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder by Syouichi Katayama, Noriyuki Sueyoshi, Tetsuya Inazu, Isamu Kameshita

“…Cyclin-dependent kinase-like 5 (CDKL5, also known as STK9) is a serine/threonine protein kinase originally identified in 1998 during a transcriptional mapping project of the human X chromosome. Thereafter, a mutation in CDKL5 was reported in individuals with the atypical Rett syndrome, a neurodevelopmental disorder, suggesting that CDKL5 plays an important regulatory role in neuronal function. …”
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Facioscapulohumeral muscular dystrophy type 1 combined with becker muscular dystrophy: a family case report by Menglin Tan, Huiyi Huo, Jieming Feng, Chandi Wang, Suhua Jiang

“…Genetic testing showed that the number of D4Z4 repeat units in the sub-terminal region 4qA of chromosome 4q35 in the proband was only 4 (normal value ≥ 11) and, at the same time, a heterozygous deletion was found in exons 13–29 of DMD gene in the proband, thus the diagnosis was clinically and genetically compatible with both FSHD1 and BMD. …”
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H3K56 acetylation regulates chromatin maturation following DNA replication by Shoufu Duan, Ilana M. Nodelman, Hui Zhou, Toshio Tsukiyama, Gregory D. Bowman, Zhiguo Zhang

“…These findings establish a central role of H3K56ac in chromatin maturation and reveal a mechanism regulating this critical aspect of chromosome replication.…”
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Metabolism of Mycotoxins, Intracellular Functions of Vitamin B12, and Neurological Manifestations in Patients with Chronic Toxigenic Mold Exposures. A Review by Ebere C. Anyanwu, Mohammed Morad, Andrew W. Campbell

“…The overall functions of vitamin B12 as a source of coenzymes, in intracellular recycling of methionine, in methionine synthase reaction, in the prevention of chromosome breakage, in methylation, and in maintaining a one-carbon metabolic balance are reviewed. …”
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Functionally-informed fine-mapping identifies genetic variants linking increased CHD1L expression and HIV restriction in monocytes by Riley H. Tough, Paul J. McLaren, The International Collaboration for the Genomics of HIV

“…A recent genome-wide association study in individuals of African ancestries identified a region on chromosome 1 significantly associated with decreased HIV set-point viral load. …”
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Comparative Genome Characterization of a Petroleum-Degrading Bacillus subtilis Strain DM2 by Shi-Weng Li, Meng-Yuan Liu, Rui-Qi Yang

“…The genome of strain DM2 consists of a circular chromosome of 4,238,631 bp for 4458 protein-coding genes and a plasmid of 84,240 bp coding for 103 genes. …”
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Permanent Sensorineural Deafness in a Patient with Chronic Myelogenous Leukemia Secondary to Intracranial Hemorrhage by Sakshi Kapur, Michael Wax, Levin Miles, Adnan Hussain

“…Results confirmed Philadelphia chromosome positive chronic myelogenous leukemia (chronic phase). …”
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Yeast silent mating type loci form heterochromatic clusters through silencer protein-dependent long-range interactions. by Adriana Miele, Kerstin Bystricky, Job Dekker

“…We have employed live cell 3-D imaging and chromosome conformation capture (3C) to determine the contribution of nuclear positioning and heterochromatic factors in mediating associations of the silent mating type loci. …”
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Genetic optimization–based scheduling in maritime cyber physical systems by Tingting Yang, Hailong Feng, Jian Zhao, Ruilong Deng, Ying Wang, Zhou Su

“…Specially, the genetic based algorithm as well as the improved genetic based algorithm are described in detail, including a novel chromosome representation, a heuristic initialization procedure, as well as a modified crossover and mutation process. …”
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Optimizing Ontology Alignment through Linkage Learning on Entity Correspondences by Xingsi Xue, Chaofan Yang, Chao Jiang, Pei-Wei Tsai, Guojun Mao, Hai Zhu

“…Compact encoding mechanism does not need to store and maintain the whole population in the memory during the evolving process, and the utilization of linkage learning protects the chromosome’s building blocks, which is able to reduce the algorithm’s running time and ensure the alignment’s quality. …”
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Association mapping and candidate gene identification for yield traits in European hazelnut (Corylus avellana L.) by Asena Akköse Baytar, Ertuğrul Gazi Yanar, Anne Frary, Sami Doğanlar

“…Furthermore, we identified 23 loci of multiple QTs comprising chromosome locations associated with more than one trait at the same position or in close proximity. …”
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Design of an Evolutionary Approach for Intrusion Detection by Gulshan Kumar, Krishan Kumar

“…In this paper, a three-phase, approach is proposed to generate solutions to a simple chromosome design in the first phase. In the first phase, a Pareto front of noninferior individual solutions is approximated. …”
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A Biphasic Pleural Tumor with Features of an Epithelioid and Small Cell Mesothelioma: Morphologic and Molecular Findings by Sarah Hackman, Richard D. Hammer, Lester Layfield

“…Array based-comparative genomic hybridization (a-CGH) confirmed the tumor had numerous chromosome copy number losses, including 11p15.5-p11.12 and 22q12.1-q13.33, with loss of the EWSR1 and WT1 gene regions. …”
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