Mesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations by María Piñeiro-Ramil, Iván Gómez-Seoane, Ana Isabel Rodríguez-Cendal, Isaac Fuentes-Boquete, Silvia Díaz-Prado

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The role of N6-methyladenosine (m6A) mediated LncRNA DDIT3 upregulation in chondrocyte ferroptosis in ankylosing spondylitis by Huiping Wang, Cong Wang, Zhansheng Zhu, Renren Li

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Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis by Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S

“…The dual luciferase experiment demonstrated that ZEB2 was the target gene of miR-200c-3p.Conclusion: The synergistic effect of AgPEI and miR-200c-3p can inhibit the inflammatory response, apoptosis, and matrix degradation of chondrocytes. Lipo-AgPEI-miR-200c-3p can also improve transfection efficiency and obtain good physicochemical properties of drugs. miR-200c-3p may be crucial in the development of OA and can influence the target gene ZEB2, control the inflammatory response, apoptosis, and chondrocyte matrix breakdown.Keywords: microfluidic synthesis, miR-200c-3p, lipid nanoparticles, osteoarthritis, ZEB2…”
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Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses by Zhantao Deng, Jiewen Jin, Jianning Zhao, Haidong Xu

“…In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). …”
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Short-term high-fat diet post-ACLT surgery activates chondrocyte AMPK pathway and slows articular cartilage degeneration in rats by Hongri Ruan, Tingting Zhu, Tianwen Ma, Yun Liu, Jiasan Zheng

“…In vitro experiments reveal that low concentrations of FFAs stimulate chondrocyte proliferation and energy metabolism, whereas AMPK inhibition leads to elevated expression of inflammatory mediators and ECM-degrading enzymes in chondrocytes. …”
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Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis by Gu Man, Haiwen Yang, Kai Shen, Donghong Zhang, Julin Zhang, Hao Wu, Hongyu Zhang, Jinhuan Wang

“…Circular RNA RHOT1 enhances the CCND1 expression by sponging miR-142-5p to inhibit chondrocyte autophagy and promote chondrocyte proliferation in osteoarthritis. …”
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IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes by Yusuke Watanabe, Aki Namba, Yukiko Aida, Kazuhiro Honda, Hideki Tanaka, Naoto Suzuki, Hideo Matsumura, Masao Maeno

“…Conditioned medium from IL-1β-treated chondrocytes decreased TRAP staining in RAW264.7 cells. …”
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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…Osteoarthritis (OA) is an age-related chronic inflammatory disease, predominantly characterized by chondrocyte senescence and extracellular matrix (ECM) degradation. …”
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Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1β in Osteoarthritic Chondrocytes by Julia Platas, Maria Isabel Guillén, María Dolores Pérez del Caz, Francisco Gomar, Vicente Mirabet, Maria José Alcaraz

“…CM enhanced type II collagen expression in OA chondrocytes while decreasing matrix metalloproteinase (MMP) activity in cell supernatants as well as the levels of MMP-3 and MMP-13 proteins and mRNA in OA chondrocytes stimulated with interleukin- (IL-) 1β. …”
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Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans by Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang

“…We demonstrated that Sema3A is a key molecule in maintaining cartilage homeostasis from chondrocyte hypertrophy via activating the PI3K pathway. …”
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lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p by Xiangkun Wu, Shuai Yin, Lihua Yan, Yongxi Liu, Lilin Shang, Jun Liu

“…Moreover, we demonstrated that DLEU1 targets miR-671-5p expression in chondrocytes. Overexpression of DLEU1 suppresses miR-671-5p expression in chondrocytes. …”
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Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat by John Garcia, Claire Mennan, Helen S. McCarthy, Sally Roberts, James B. Richardson, Karina T. Wright

“…Autologous chondrocyte implantation (ACI) is a cell-based therapy that has been used clinically for over 20 years to treat cartilage injuries more efficiently in order to negate or delay the need for joint replacement surgery. …”
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Self‐Healing Hyaluronic Acid‐based Hydrogel with miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach by Wei Zhu, Han Wang, Bin Feng, Guangli Liu, Yixin Bian, Tianhao Zhao, Qi Wang, Xisheng Weng

Subjects: “…chondrocyte regeneration…”
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EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis by Yang Chen, Shanshan Dong, Xin Zeng, Qing Xu, Mingwei Liang, Guangneng Liao, Lan Li, Bin Shen, Yanrong Lu, Haibo Si, Peifang Wei

“…Enhanced endoplasmic reticulum (ER) stress and increased pyroptosis in chondrocytes may be responsible for cartilage degeneration. …”
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Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway by Junzheng Yang, Delong Chen, Qi He, Baihao Chen, Zhaofeng Pan, Gangyu Zhang, Miao Li, Shaocong Li, Jiacong Xiao, Haibin Wang, Peng Chen, Zhantian An

“…We aimed to elucidate that Arctiin (ARC) plays a role in managing KOA caused by accumulated iron levels by restoring chondrocyte apoptosis and ferroptosis. Single-cell RNA sequencing analysis was used to discover the disparities in chondrocytes between KOA patients and non-KOA individuals. …”
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Fibroblast Growth Factor 18 Increases the Trophic Effects of Bone Marrow Mesenchymal Stem Cells on Chondrocytes Isolated from Late Stage Osteoarthritic Patients by Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian Wu

“…Coculture of mesenchymal stem cells with chondrocytes increases production of cartilaginous matrix. …”
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Corrigendum to “TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence” [Experimental Gerontology Volume 195 (2024) 1-8 /112546] by Limeiting Wang, Jun Zhang, Lu Liang, Zijun Song, Pinwen Wang, Liya Ma, Zhenhui Liao, Ning Li, Hefeng Yang, Song Li

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Arctiin alleviates the progression of osteoarthritis by regulating the cholesterol metabolic pathway by Jiale Mai, Jiacong Xiao, Yanhuai Ma, Dawei Gong, Jianliang Li

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The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels by Guanglei Zhao, Jinyang Lyu, Xin Huang, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang, Jun Xia, Jie Chen, Jingsheng Shi

“…Conclusions Furthermore, DPSC-exosomes show an ability to promote autophagy in chondrocytes through mTOR inhibition, in addition to reducing the mTOR luciferase activity. …”
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