Critical review of multimorbidity outcome measures suitable for low-income and middle-income country settings: perspectives from the Global Alliance for Chronic Diseases (GACD) res... by Najma Siddiqi, Meena Daivadanam, J Jaime Miranda, Trishul Siddharthan, John R Hurst, Rajesh Vedanthan, Gary Parker, Gina Agarwal, Shabbar Jaffar, Naomi Levitt, Niels H Chavannes, Pallab K Maulik, Patricio Lopez-Jaramillo, Kamran Siddiqi, Muralidhar M Kulkarni, Gillian Sandra Gould, Job F M van Boven, Kirsten Bobrow, M O Owolabi, Joan B Soriano, Erick Wan-Chun Huang, Shahirose Sadrudin Premji, Lijing Yan, Ricardo Araya, F Xavier Gómez-Olivé, Bruce J Kirenga, Rianne M J J van der Kleij, Laura Loli-Dano, Shane Norris, Josefien van Olmen, Antigona C Trofor

Get full text

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

Get full text

Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment by Kai Zhang, Xiaoxia Liu, Siyu Huang, Xinrui Liu, Meiqi Zhao, Chao Xue, Shijun Xia, Jianzeng Dong, Yu Kong, Changsheng Ma

“…Methods We conducted an age-, gender-, and education level-matched case–control study in general CVD participants with a 1:3 ratio of MCI (Montreal Cognitive Assessment [MoCA] score < 26 and Mini-Mental State Examination [MMSE] score ≥ 24) and cognitively normal participants at a tertiary hospital in Beijing, China. The echocardiographic cardiac parameters and cognitive status were retrieved through the clinical electronic database from May 2021 to August 2023. …”
Get full text

Examining the impacts of input factor application, production efficiency, and inefficiency model on maize yield: employing the stochastic frontier model in search of more efficient... by Muslim Salam, Ayu Anisa Amir, A Nixia Tenriawaru, Muhammad Hatta Jamil, Letty Fudjaja, Muhammad An-Nashrullah K Samma, Ahmad Imam Muslim, Hamed Noralla Bakheet Ali, Muhammad Ridwan

Get full text

Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…In the Lingnan region of China, high summer temperatures and humidity often cause symptoms like diminished appetite, sticky tongue coating, sticky stool, unsatisfactory defecation, lethargy, and joint heaviness. …”
Get full text

The Mechanical Power in Patients with Acute Respiratory Distress Syndrome Undergoing Prone Positioning Can Predict Mortality by Ko-Wei Chang, Shaw-Woei Leu, Han-Chung Hu, Ming-Cheng Chan, Shinn-Jye Liang, Kuang-Yao Yang, Li-Chung Chiu, Wen-Feng Fang, Chau-Chyun Sheu, Ying-Chun Chien, Chung-Kan Peng, Ching-Tzu Huang, Kuo-Chin Kao

Get full text

Effectiveness and Safety of the TRIO Optimal Health Management Program in Patients With Type 2 Diabetes Mellitus Initiating Basal Insulin Therapy: Prospective Observational Real-Wo... by Chenxi Li, Lixin Guo, Lixin Shi, Li Chen, Liming Chen, Yaoming Xue, Hong Li, Yuzhen Liang, Jing Yang, Weimin Wang, Dalong Zhu

“…ResultsA total of 199,431 patients were included, and 118,134 patients completed the 3-month follow-up between December 1, 2019, and December 31, 2021, involving 574 hospitals in China. The mean baseline HbA1c was 9.2%, the mean duration of diabetes was 7.3 years, and 80.4% (1,59,930/1,98,969) of patients were using BI with oral antihyperglycemic drugs. …”
Get full text

Prevention of mother-to-child transmission of hepatitis B virus: protocol for a one-arm, open-label intervention study to estimate the optimal timing of tenofovir in pregnancy by François Nosten, Rose McGready, Verena Carrara, Stephan Ehrhardt, Chaisiri Angkurawaranon, Nan Guo, Yuanxi Jia, Marieke Bierhoff, Kenrad E Nelson, Podjanee Jittamala, Wanitda Watthanaworawit, Clare Ling, Fuanglada Tongprasert, Michele van Vugt, Marcus Rijken, Chloe Lynne Thio

Get full text

mHealth-Based Diabetes Prevention Program for Chinese Mothers With Abdominal Obesity: Randomized Controlled Trial by Qinyuan Huang, Qinyi Zhong, Yanjing Zeng, Yimeng Li, James Wiley, Man Ping Wang, Jyu-Lin Chen, Jia Guo

“…MethodsA randomized controlled trial was conducted at health management centers in 2 tertiary hospitals in Changsha, China. The mHealth group (n=40) received 12 weekly web-based lifestyle modification modules for diabetes prevention, 6 biweekly individualized health education messages based on their goal settings, and a Fitbit tracker. …”
Get full text

Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts by Yanqiu Huang, Yi Zhou, Yadan Xu, Xiaoyu Wang, Ziyi Zhou, Kang Wu, Qiqi Meng, Liao Wang, Yang Yang, Hong Gao, Juan Ji, Xu Jiang, Yang Yang, Lipeng Hao, Hui Wang

“…Higher glucose triglyceride-waist height ratio (TyG-WHTR) was linked to higher all-cause mortality (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: HR 1.17, 95%CI 1.00–1.36), CVD mortality (UKBB: HR 1.36, 95%CI 1.23–1.49, NHANES: HR 1.32, 95%CI 1.00–1.72) risks. In the China Pudong cohort, higher triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) ratio was associated with higher risks of CVD and stroke (HR 1.31, 95%CI 1.00–1.73 and 1.67, 1.06–2.63). …”
Get full text

Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machin... by Lele Ye, Chunhao Long, Binbing Xu, Xuyang Yao, Jiaye Yu, Yunhui Luo, Yuan Xu, Zhuofeng Jiang, Zekai Nian, Yawen Zheng, Yaoyao Cai, Xiangyang Xue, Gangqiang Guo

Get full text

Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

Get full text

Association of iron deficiency with kidney outcome and all-cause mortality in chronic kidney disease patients without anemia by Hongxue Yu, Xian Shao, Zhixin Guo, Mingzhen Pang, Shan Chen, Caoxiang She, Lisha Cao, Fan Luo, Ruixuan Chen, Shiyu Zhou, Xin Xu, Sheng Nie

“…Methods This multicenter retrospective nationwide cohort study included adult patients with non-anemia NDD-CKD from 24 hospitals across China. The study investigated the associations between serum ferritin or transferrin saturation (TSAT) levels and the risks of CKD progression and all-cause mortality. …”
Get full text

Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…The MDR plasmids and resistant GIs were phylogenetically relevant to Europe, USA, or China-derived isolates, indicating carry-over of the emerging ARGs from heavily industrialized countries and MSM-burdened (men who have sex with men) populations. …”
Get full text

Plateau hypoxia improves tumor immune microenvironment and inhibits subcutaneous tumor growth of colorectal cancer by ZHAO Sijie, WANG Meng, GAO Yuan

Get full text

Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…Based on the screening results, research on nitrifying bacteria in mangrove sediments is geographically limited to several countries such as Indonesia, Vietnam, Thailand, China, Mexico, the United States, India, and Saudi Arabia. …”
Get full text

Global comparison of the economic costs of coronary heart disease: a systematic review and meta-analysis by Lan Gao, Susan Brumby, Crystal Man Ying Lee, George Mnatzaganian, Suzanne Robinson, Helen Brown, Rachel Huxley, Anna Peeters, Dan Xu, James Boyd, Sean Randall, Adrienne O’Neil, Sangita Shakya, Sarah Gauci, Anita Shrestha, James Lucas

Get full text

Population structure, floral diversity, habitat geography, and conservation status of Himalayan horse chestnut (Aesculus indica) in western Himalayan moist temperate forest ecosyst... by Urwa Irfan, Hamayun Shaheen, Muhammad Manzoor, Muhammad Manzoor, Sidra Nasar, Raja Waqar Ahmed Khan, Syed Waseem Gillani, Syed Waseem Gillani, Abdulwahed Fahad Alrefaei, Arbaz Attique, Asif Kamal, Sarah Abdul Razak, Malik Talha Riaz

Get full text

Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial by Yongli Tao, Yuan Gao, Lu Zhao, Yafang Xu, Chenyang Jiang, Kai Liu, Hui Fang, Lulu Pei, Xin Wang, Rui Zhang, Jun Wu, Jing Yang, Xinsheng Han, Hongling Guo, Baoguo Xue, Jinlou Li, Yuqian Liu, Hongqiu Gu, Kejin Du, Xin Cheng, Qiang Dong, Duolao Wang, Ferdinando S. Buonanno, MingMing Ning, Yuming Xu, Bo Song, the TRUST Trial Investigators

“…The trial was conducted at 25 hospitals in China between October 2020 and February 2023. Eligible patients were randomized to the UK group (1,000,000 U) or the best medicine treatment group. …”
Get full text

Assessment of genetic diversity in Sehima nervosum for yield, nutritional traits and ensiling quality by Sultan Singh, Tejveer Singh, Neeraj Kumar, Pushpendra Koli, Madan Mohan Das, Sanat Kumar Mahanta, Krishna Kumar Singh, Prakash K. Jha, PV Vara Prasad, Manoj Kumar Srivastava, Rohit Katiyar

“…Sehima is a prominent range grass of Sehima-Dichatnthium grasslands in India followed by Africa, Pakistan, China and Australia. In this study, 92 diverse SN germplasm accessions were evaluated for biomass yield, nutritional quality and sugar content. …”
Get full text