Discordant CAR-T cell signaling: implications of divergence from physiological T cell activation by Pablo Gonzalez-Garcia, Noelia Moares, Isabel Serrano-García, Ricardo Fernandez-Cisnal, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Wenjie Yi-He, Juan P. Muñoz-Miranda, Antonio Gabucio, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar

Subjects: “…Chimeric antigen receptors (CAR)…”
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Editorial: Immunotherapy resistance and advancing adaptive cell therapeutics by Luciana Rodrigues Carvalho Barros, Amar Yeware

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New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies by Yuanyuan Yang, Hongwei Peng, Jianxiang Wang, Fei Li

Subjects: “…Chimeric antigen receptor (CAR)…”
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Dap10 co-stimulation enhances the anti-HCC efficacy of NKp30 chimeric antigen receptor T cells by JieYu Li, LiMei Chen, MingShui Chen, Miao Lin, Zineng Xie, HuiLing Wu, ZhiFeng Zhou, WanSong Lin

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Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy by Ali Moazzeni, Maryam Kheirandish, Gholamreza Khamisipour, Fatemeh Rahbarizadeh, Ali Akbar Pourfathollah

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Can chimeric antigen receptors – based therapy bring a gleam of hope for thyroid-associated ophthalmopathy and other autoimmune diseases? by Zhou Weiyi, Zhu Xinyu, Shi Yongquan

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γδT cells, a key subset of T cell for cancer immunotherapy by Jianzhen Lv, Zheng Liu, Xiangting Ren, Siyuan Song, Yan Zhang, Yi Wang, Yi Wang

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Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways by Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu

Subjects: “…Chimeric antigen receptor (CAR)-NK cells…”
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Dose-dependent impact of tixagevimab–cilgavimab as primary prevention against SARS-CoV-2 in immunocompromised individuals by Daniela Dluzynski, Paddy Ssentongo, Cory M. Hale, Shareef K. Shaheen, Natella Maglakelidze, Jeffrey M. Sivik, Maria Paula Henao, Vernon M. Chinchilli, Catharine I. Paules

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Siltuximab for the treatment of early complications after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia in children, adolescents, and young adults by Víctor Galán-Gómez, Berta González-Martínez, Anna Alonso-Saladrigues, Susana Rives, Blanca Herrero, Mi Kwon, Jose Sánchez-Pina, Jordi Minguillón, Isabel Martínez-Romera, Isabel Mirones Aguilar, Carmen Mestre-Durán, Gema Casado, María Sánchez-Martín, Carlos Echecopar, Carlos González-Pérez, Odelaisy León-Triana, Cristina Aguirre-Portolés, Águeda Molinos-Quintana, Pere Barba, Pascual Balsalobre, Antonio Pérez-Martínez

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Outcomes-based reimbursement for gene therapies in practice: the experience of recently launched CAR-T cell therapies in major European countries by Jesper Jørgensen, Eve Hanna, Panos Kefalas

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Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM by Danielle R. Cook, Alina C. Boesteanu, Yibo Yin, Yibo Yin, Reiss Reid, Laura Roccograndi, Nadia Dahmane, Maria Martinez-Lage, Donald M. O’Rourke, Carl H. June, Carl H. June, Laura A. Johnson, Laura A. Johnson

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Development of a workflow for in vitro on– and off-target cytotoxicity assessment of CAR T cell therapies to support first-in-human clinical trials: An orthogonal approach using hu... by Shari Price, Krista G. Zindel, Joshua K. Overcash, Elizabeth Glaze, Sandy Eldridge

Subjects: “…Chimeric antigen receptor (CAR) T cells…”
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Regulatory T cell therapy in autoimmune liver disease and transplantationKeypoints by Maegen Fleming, Alberto Sanchez-Fueyo, Niloufar Safinia

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Risk of Severe COVID-19 in Four Immunocompromised Populations: A French Expert Perspective by Paul Loubet, Ilies Benotmane, Slim Fourati, Florent Malard, Fanny Vuotto, Elodie Blanchard, François Raffi, Stéphanie Nguyen, Nicolas de Prost, Jérôme Avouac

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Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

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Chimeric antigen receptor dendritic cells targeted delivery of a single tumoricidal factor for cancer immunotherapy by Rong Duan, Philip Milton, Chutamath Sittplangkoon, Xin Liu, Zhining Sui, Brendan F. Boyce, Zhenqiang Yao

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T cell exhaustion in pediatric B-ALL: current knowledge and future perspectives by Tanmaya Atre, Gregor S. D. Reid, Gregor S. D. Reid

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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

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CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs by Matteo Doglio, Jyoti Rana, Adriana Stucchi, Maite-Muñoz Melero, Alessia Ugolini, Tatiana Jofra, Cristiano Toma, Clara Bercher-Brayer, Pierluigi Carulli, Sandeep Kumar, Paolo Monti, Elisa Martini, Senthilkumar Thirumurugan, Moanaro Biswas, Chiara Bonini, Georgia Fousteri

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