Resolution of Crizotinib-Associated Fulminant Hepatitis following Cessation of Treatment by Gregory W. Charville, Sukhmani K. Padda, Richard K. Sibley, Ajithkumar Puthillath, Paul Y. Kwo

“…We discuss the case of a 26-year-old female with a history of ROS1-rearranged lung adenocarcinoma, undergoing treatment with the tyrosine kinase inhibitor crizotinib, who presented to our hospital with abdominal pain and scleral icterus. Liver chemistries were notable for hyperbilirubinemia (5 mg/dL total) and marked transaminasemia (AST 1736 U/L, ALT >3500 U/L); liver biopsy demonstrated acute hepatitis with extensive necrosis. …”
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Unconventional Nuclides for Radiopharmaceuticals by Jason P. Holland, Matthew J. Williamson, Jason S. Lewis

“…With the increased availability of small, low-energy cyclotrons and improvements in both cyclotron targetry and purification chemistries, the use of “nonstandard” radionuclides is becoming more prevalent. …”
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Evolutionary Trajectories of Shoots vs. Roots: Plant Volatile Metabolomes Are Richer but Less Structurally Diverse Belowground in the Tropical Tree Genus <i>Protium</i> by Katherine D. Holmes, Paul V. A. Fine, Italo Mesones, Julieta Alvarez-Manjarrez, Andressa M. Venturini, Kabir G. Peay, Diego Salazar

“…Plants also experience strong pressure from enemies such as belowground pathogens; however, little work has been carried out to examine the evolutionary trajectories of species’ specialized chemistries in both roots and leaves. Here, we examine the GCMS detectable phytochemistry (for simplicity, hereafter referred to as specialized volatile metabolites) of the tropical tree genus <i>Protium</i>, testing the hypothesis that phenotypic divergence will be weaker belowground compared to aboveground due to more limited dispersal by enemies. …”
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Case-based analysis of mechanically-assisted leaching for hydrometallurgical extraction of critical metals from ores and wastes: application in chalcopyrite, ferronickel slag, and... by Laskar, Clément, Dakkoune, Amine, Julcour, Carine, Bourgeois, Florent,  Biscans, Béatrice, Cassayre, Laurent

“…Despite very different system chemistries and conditions, the particle size distribution is similar for the three materials, showing that particles’ behavior is controlled by the attrition environment. …”
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Martini compatible coarse-grained model of polyethylenimine for pulmonary gene delivery by Graham Lunt, Niloofar Hashemi, Subhamoy Mahajan, Tian Tang

“…Differences in hydrophobicity of plasma membrane and pulmonary surfactant require different chemistries of gene carriers to improve efficacy. Large-scale coarse-grained (CG) molecular dynamics simulations would facilitate the screening of gene carriers and understanding of the molecular mechanisms involved in pulmonary delivery. …”
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A Reduced-Order Model of Lithium–Sulfur Battery Discharge by Noushin Haddad, Hosam K. Fathy

“…Zero-dimensional models typically succeed in capturing key features of Li-S battery discharge, including the high plateau, low plateau, and dip point visible in the discharge curves of certain Li-S battery chemistries. However, these models’ use of one state variable to represent the mass of each active species tends to furnish high-order models, with many state variables. …”
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Quantification and discovery of PCR inhibitors found in food matrices commonly associated with foodborne viruses by Cassandra Suther, Matthew D. Moore

“…Although some studies have been done on PCR inhibitors from foods, many of them are over a decade old and do not investigate inhibition in contemporary one-step RT-qPCR-based detection chemistries. The purpose of this work was to quantify the degree of inhibition that occurs from inhibitory compounds found in produce (pectin) and mollusks (hemocyanin, glycogen)—foods commonly associated with norovirus outbreaks. …”
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Energetic and genomic potential for hydrogenotrophic, formatotrophic, and acetoclastic methanogenesis in surface-expressed serpentinized fluids of the Samail Ophiolite by Alta E. G. Howells, Alta E. G. Howells, Lilja M. Quinn, Lilja M. Quinn, Miguel G. Silva, Miguel G. Silva, Kylie Akiyama, Kylie Akiyama, Lucas M. Fifer, Lucas M. Fifer, Grayson Boyer, Srishti Kashyap, Kirt Robinson, Kirt Robinson, Jared Broddrick, Everett L. Shock, Tori M. Hoehler

“…In this study we quantified the impact of inorganic carbon, formate and acetate availability for methanogenic metabolisms, across a range of fluid chemistries, in terms of (1) the potential diffusive flux of substrates to the cell, (2) the Affinity (Gibbs energy change) associated with methanogenic metabolism, and (3) the energy “inventory” per kg fluid. …”
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Lithological and geochemical characterization of ‘adinole’ artefacts from cave deposits in southwest Wales: A material of choice during the late Middle to Upper Palaeolithic by Richard Bevins, Elizabeth A. Walker, Nick Pearce, Duncan Pirrie, Rob Ixer, Ian Saunders, Matthew Power

“…In other cases, however, certain artefacts with similar chemistries have dissimilar petrological characteristics and are not from a common source. …”
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Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, C... by Nattaphol Uransilp, Pannawat Chaiyawatthanananthn, Sombat Muengtaweepongsa

“…Personal data and past history of all patients were recorded at baseline. The blood chemistries were measured by standard laboratory techniques. …”
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EV Hybrid Battery With Integrated Multilevel Neutral-Point-Clamped Interfacing and Lossless Intermodule State-of-Charge Balancing by Gabriel Garcia-Rojas, Sergio Busquets-Monge, Alber Filba-Martinez, Turev Sarikurt, Salvador Alepuz, Josep Bordonau

“…Instead, hybrid batteries, combining only two battery cell chemistries, with distinct particular strengths, such as high specific energy or high specific power, offer an opportunity to cover a wide range of vehicle battery specifications while avoiding oversizing and dispersion in the cells to be employed. …”
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