A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…BackgroundLactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial respiration. …”
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Enhancing thermoelectric properties of ScN films through twin domains by J. More-Chevalier, U.D. Wdowik, J. Martan, T. Baba, S. Cichoň, P. Levinský, D. Legut, E. de Prado, P. Hruška, J. Pokorný, J. Bulíř, C. Beltrami, T. Mori, M. Novotný, I. Gregora, L. Fekete, L. Volfová, J. Lančok

“…The microstructure of the produced thin films is examined by X-ray diffraction and atomic force microscopy, while their chemical composition and contamination by defects are determined by X-ray photoelectron spectroscopy. …”
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Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Top predictions made by Pathopticon have high chemical structural diversity, suggesting their potential for building compound libraries. …”
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Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

“…To modulate UGT2B15 expression, we employed siRNA and (R)/(S)-NAF (naftopidil), a chemical inducer of UGT2B15 identified in our previous studies on a prostate hyperplasia model. …”
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Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract by Anuwatchakij Klamrak, Shaikh Shahinur Rahman, Napapuch Nopkuesuk, Jaran Nabnueangsap, Jaraspim Narkpuk, Piyapon Janpan, Yutthakan Saengkun, Thananya Soonkum, Supawadee Sriburin, Samaporn Teeravechyan, Poramet Sitthiwong, Nisachon Jangpromma, Sirinan Kulchat, Kiattawee Choowongkomon, Rina Patramanon, Arunrat Chaveerach, Jureerut Daduang, Sakda Daduang

“…Abstract In a recent study, we used chemical analysis to show that the Caesalpinia mimosoides aqueous extract, which contains a high concentration of simple phenolics, has strong anti-influenza activity. …”
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Automated multidimensional deep learning platform for referable diabetic retinopathy detection: a multicentre, retrospective study by Chi Pui Pang, Weiqi Chen, Mingzhi Zhang, Tsz Kin Ng, Yi Zheng, Guihua Zhang, Jian-Wei Lin, Ji Wang, Jie Ji, Ling-Ping Cen, Peiwen Xie, Yongqun Xiong, Hanfu Wu, Dongjie Li

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Screening and Identification of Cold-Tolerant Phosphorus and Potassium Solubilizing Bacteria and Their Growth-Promoting Effects on Soybean in Cold Regions by Hao Yan, Tianyi Wang, Haocheng Wang, Nan Sun, Xuebing Wang, Xingbo Zhao, Zhongbao Yao, Hao Tian, Shengjie Chen, Songyan Tang, Chenyang Li

“…This study has important theoretical value for the replacement of chemical fertilizer application by microbial agents in the cold region of China, and it has important practical and strategic significance for the promotion of income green safety in China’s main grain-producing areas.…”
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3D Coaxial Printing of Small‐Diameter Artificial Arteries by Yuxiang Zhu, Siying Liu, Xuan Mei, Zeng Lin, Tiffany V. Pulido, Jixin Hou, Srikar Anudeep Remani, Dhanush Patil, Martin Taylor Sobczak, Arunachalam Ramanathan, Sri Vaishnavi Thummalapalli, Lindsay B. Chambers, Churan Yu, Shenghan Guo, Yiping Zhao, Yang Liu, Xianqiao Wang, Jessica N. Lancaster, Yu Shrike Zhang, Xiangfan Chen, Kenan Song

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Interventions used to reduce infectious aerosol concentrations in hospitals—a reviewResearch in context by Gráinne Brady, Fiona Bennin, Rosaline De Koning, Cecilia Vindrola-Padros, Sigrún Eyrúnardóttir Clark, Manish K. Tiwari, Simon Watt, Andrea Ducci, Ryo Torii, Danielle Morris, Elizabeth Lloyd-Dehler, Jerry Slann, Fiona Stevenson, Zarnie Khadjesari, Hakim-Moulay Dehbi, Lena Ciric, Ruth Epstein, John Rubin, Catherine F. Houlihan, Rachael Hunter, Laurence B. Lovat

“…Whilst these efforts can contribute to improved air quality in hospitals, they should be considered with the other interacting factors such as microclimates, room dimensions and use of chemical products that effect air quality. Funding: This study is funded by the National Institute for Health and Care Research (NIHR) (NIHR205439).…”
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Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis by Junxian Hu, Junxian Hu, Yibo Zhu, Yibo Zhu, Zeyu Pang, Zeyu Pang, Xiaoxiao Li, Xiaoxiao Li, Huilin Zhang, Huilin Zhang, Xiangwei Li, Xiangwei Li, Yongjian Gao, Yongjian Gao, Yiyang Wang, Yiyang Wang, Pei Li, Pei Li, Qiang Zhou, Qiang Zhou

“…TRPV4, a baroreceptor in the intervertebral disc, is primarily responsible for converting extracellular pressure signals into intracellular chemical signals. Upon activation, TRPV4 facilitates the influx of calcium ions, thereby regulating the physiological behavior of NP cells. …”
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Pollution index and load of total nitrogen and phosphate on agriculture and fisheries in Jatigede Reservoir by Zulfia Kamila Mutia, Denny Kurniadie, Dadan Sumiarsa

“…Problems arising from the use of chemical fertilizers, regarding the development of agricultural land used to increase agricultural productivity, support food security and also activities in floating net cages (FNC) can result in a decrease in reservoir water quality, siltation of reservoirs, etc. …”
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Numerical simulation of Stephan blowing impacts on thermally laminated 3D flow of MHD trihybrid nanofluid with Soret and Dufour effects by Noureddine Elboughdiri, Munawar Abbas, Hamdi Ayed, Abir Mouldi, Nahid Fatima, Dilsora Abduvalieva, Mohamed Said, Ibrahim Mahariq, Ahmed S. Hendy, Ahmed M. Galal

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Balanced displacement methods and effect evaluation of heterogeneous combination flooding in different reservoirs by Dejun WU, Jian HOU, Lijie LIU, Kang ZHOU, Zhibin AN

“…However, because of the complex heterogeneity of the actual formation, differences in the deployment of interlayer well networks, and different injection volumes of chemical agents in different layers, the extraction of planar and vertical remaining oil by heterogeneous combination flooding is affected. …”
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Correlation between aboveground vegetation composition and soil seed bank of Raudhat desert habitat: a case study of Raudhat Alkhafs, Saudi Arabia by Asma A. Al-Huqail, Hanan F. Al-Harbi, Abdullah M. Alowaifeer, Mohamed A. El-Sheikh, Abdulaziz M. Assaeed, Turki S. Alsaleem, Hazem S. Kassem, Omar M. Azab, Basharat A. Dar, Jahangir A. Malik, Ahmed M. Abd-ElGawad

“…Soil samples were collected from each site for seed bank analysis through seedling emergence techniques and for chemical and physical analyses. Eighty-three plant species were recorded (50.6% perennial and 49.4% annual plants). …”
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Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater by Bui Van Hoi, Cam-Tu Vu, Lan-Anh Phung-Thi, Thao Thi Nguyen, Phuong Thanh Nguyen, Huong Mai, Phuong-Thu Le, Thanh-Hien Nguyen, Dao Thanh Duong, Hue Nguyen Thi, Dung Le-Van, Dinh Binh Chu

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Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation by Anis Adibah Osman, Siok-Fong Chin, Lay-Kek Teh, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal

“…Metabolites were identified using a molecular feature and chemical formula algorithm, followed by a differential analysis using MetaboAnalyst 5.0. …”
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Utilization of hydrolyzed corncob as a carbohydrate source in diets for red Nile tilapia Oreochromis niloticus by Fauzan, Muhammad Agus Suprayudi, Ichsan Achmad Fauzi, Julie Ekasari

“…The first study step was enzymatic hydrolysis using 0.4 g/kg cocktail enzyme, followed by chemical hydrolysis using hydrochloric acid (HCl) at different treatments, i.e. concentration, incubation period, and ratio. …”
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3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

“…3-methyl-4-nitrophenol (PNMC), a chemical prevalent in various industries for drug, dye, and leather production, also serves as a primary byproduct of organophosphate insecticides. …”
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Isomeric Differentiation of Four Triterpene Acids Using Full Collision Energy Ramp-MS2 Analysis by Li-juan WU, Rui-ru NAN, Qian WANG, Xin CHEN, Wen-jing LIU, Yue-lin SONG

“…Various methods have been employed to differentiate triterpene acid isomers, including liquid chromatography, mass spectrometry, and chemical derivatization coupled with mass spectrometry. …”
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