Checkmate to Bioethics? by Fabio Alberto Garzón Díaz

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Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the CheckMate 9LA randomized trial by Enriqueta Felip, David P. Carbone, Martin Reck, Luis Paz-Ares, Yong Yuan, Nan Hu, Niels Reinmuth, Xiaoqing Zhang, Thomas John, Ying Cheng, Shun Lu, Manuel Cobo, Michael Schenker, Tudor-Eliade Ciuleanu, Stéphanie Bordenave, Oscar Juan-Vidal, Juliana Menezes, Eduardo Richardet, Hideaki Mizutani, Bogdan Zurawski, Aurelia Alexandru, Javed Mahmood, Tuli De, Irene Santi, John R. Penrod, Adam Lee

“…Background In CheckMate 9LA, nivolumab plus ipilimumab with chemotherapy prolonged overall survival (OS) versus chemotherapy regardless of tumor PD-L1 expression or histology. …”
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The Brass-Bells Drum: An African Literary Writer’s imaging of Neo-colonial woes in Nigeria by Arinpe G. Adejumo, Emmanuel Akinyinka Ilori

“…The novelist advocates harnessing some tangible and intangible cultural heritage as well as communal revolt to checkmate the continuing spread of this menace of (mis)governance in Nigeria. …”
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Role Of Political Parties In Resolving The Challenges Confronting Nigeriafrom 1960-1966 by Mas’ud Bello, Sani Ibrahim

“…This informed the need for vibrant political parties in that critical period with good manifestoes to serve as check and balance instrument towards resolving Nigeria’s socio-economic challenges with a view to build a strong and prosperous Nation-state became imperative, therefore, this paper will examine the role of 196 0-1966 political parties in providing the required evaluation mechanisms in checkmating the excesses in democratic governance. The paper adopted the use of qualitative data obtained through; primary and secondary sources of information as well as the use of relevant existing literature. …”
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Ungoverned Spaces and Menace of Herder-Farmer Conflictin Ondo State, South West Nigeria by Adebajo Adeola Aderayo, Orebanjo Abiodun Olusola

“…Amotekun security outfit plays crucial roles in monitoring and checkmating herders who use the unmanned forests as hideouts. …”
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TRANS-BORDER TRAJECTORIES AND HUMAN SECURITY IN NIGERIA: NORTHEAST AND NORTHWEST IN PERSPECTIVE by JOSHUA OJI ZACHARIAH, ELIAS CHUKWUEMEKA NGWU

“…However, successive governments have in collaboration with leaders of neighbouring countries and independently adopted different measures to checkmate irregular trans-border movements and related security disquiets but to no avail. …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Anti-PD-1 agents were approved for advanced melanoma after the landmark trial Checkmate-037. Anti-PD-1 agents can breach immunologic tolerance. …”
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Stratification system with dual human endogenous retroviruses for predicting immunotherapy efficacy in metastatic clear-cell renal cell carcinoma by Li Xu, Stephane Oudard, Catherine Sautes-Fridman, Xiaoping Su, Gabriel G. Malouf, Virginie Verkarre, Salma Kotti, Fangrong Yan, Yann-Alexandre Vano, Wolf Herve Fridman, Cheng-Ming Sun, Xiaofan Lu, Wenxuan Cheng

“…While the dysregulation of ERV transcription has been linked to immune cell infiltration in various cancers, its relationship with immune checkpoint inhibitor (ICI) response in solid tumors, particularly metastatic clear-cell renal cell carcinoma (ccRCC), remains inadequately explored.Methods This study analyzed patients with metastatic ccRCC from two prospective clinical trials, encompassing 181 patients receiving nivolumab in the CheckMate trials (−009 to –010 and −025) and 48 patients treated with the ipilimumab-nivolumab combination in the BIONIKK trial. …”
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Relationship Between Short‐Term Outcomes and PD‐L1 Expression Based on Combined Positive Score and Tumor Proportion Score in Recurrent or Metastatic Head and Neck Cancers Treated W... by Akihiro Ohara, Taisuke Mori, Mai Itoyama, Kazuki Yokoyama, Shun Yamamoto, Ken Kato, Yoshitaka Honma

“…Conversely, nivolumab is utilized for platinum‐pretreated R/M‐HNSCC regardless of the positive tumor proportion score (TPS) following the results of the CheckMate‐141; however, its subgroup analysis indicated that TPS‐positive population tended to have a relatively high overall response rate and progression‐free survival (PFS). …”
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