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The role of chloride intracellular channel 4 in tumors
Published 2025-03-01“…Chloride intracellular channel 4 (CLIC4) belongs to the family of chloride intracellular channels (CLICs), which are widely expressed in various tissues and organs, such as the brain, lung, pancreas, colorectum, and ovary, and play important roles in promoting apoptosis, promoting angiogenesis, maintaining normal proliferation of endothelial cells, and regulating the assembly and reconstruction of the cytoskeleton. …”
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Yes, I can: a representação das pessoas com deficiência no videoclipe “We're the Superhumans” do Channel 4
Published 2018-10-01“… Este trabalho se propôs a responder a seguinte questão: De que maneira as pessoas com deficiência são retratadas no videoclipe “We're the Superhumans” produzido pelo canal de televisão inglês, Channel 4, e divulgado pelo IPC para promover os Jogos Paralímpicos Rio/2016? …”
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An In Silico Investigation of the Pathogenic G151R G Protein-Gated Inwardly Rectifying K<sup>+</sup> Channel 4 Variant to Identify Small Molecule Modulators
Published 2024-11-01“…This includes a glycine-to-arginine substitution at position 151 (G151R) of the G protein-activated inward rectifier potassium (K<sup>+</sup>) channel 4 (GIRK4), which is encoded by the <i>KCNJ5</i> gene. …”
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Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus
Published 2025-01-01Subjects: “…Inwardly rectifying potassium channel 4.1 (Kir4.1)…”
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The cyclic nucleotide-gated channels CNGC2 and CNGC4 support systemic wound responses in Arabidopsis thaliana
Published 2025-08-01Subjects: “…cyclic nucleotide gated channel 4 (CNGC4)…”
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Time Travel as Living History Exploring the Media Representation and SensualExperience of Historical Everyday Life
Published 2024-10-01“…The following productions are analysed here: The 1900 House (Channel4, GB 1999), Frontier House (PBS/Channel4, US 2002), Schwarzwaldhaus 1902 – Leben wie vor 100 Jahren (SWR, DE 2001).…”
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Samuel Beckett's Breath on Screen: Damien Hirst’s Adaptation
Published 2021-04-01“…As a collaborative work of RTÉ (Raidiό Teilifis Éireann), Channel 4 (the British broadcaster), the Irish Film Board, and Tyrone Productions, the project includes films, ranging from approximately forty-five seconds to two hours. …”
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"So you're saying": the interrogation of Jordan Peterson
Published 2021-07-01“…In this article, I analyse the infamous Cathy Newman interview with Jordan Peterson on the 16th of January 2018 and subsequent viewer comments on Channel 4's YouTube channel. My first hypothesis is that Newman's frequent attribution of statements to Peterson using the now notorious "so you are saying" gambit (YSG) is what triggered outrage among Peterson's followers, which, in turn, generated media interest. …”
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Self-Learning Efficiency in College Virtual Course of Engineering Mathematics on YouTube
Published 2024-09-01“…The viewer information provided by YouTube revealed that (1) 59.16% of viewers were 18 to 24 years old while 23.18% were over 35 years old, (2) the gender ratio was 4:1 (male–female), (3) 9.19% of viewers subscribed to the educational channel, (4) 88.13% of viewers were from Taiwan and 1.97% from Hong Kong, and (5) the proportion of “External Sources” and “Playlist” was 26.91% and 25.30%, respectively. …”
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Sex and STEM Occupation Predict Autism-Spectrum Quotient (AQ) Scores in Half a Million People.
Published 2015-01-01“…This study assesses Autism-Spectrum Quotient (AQ) scores in a 'big data' sample collected through the UK Channel 4 television website, following the broadcasting of a medical education program. …”
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Multilayered Stub Loaded-SIR for Compact Dual-BPF and Quad-channel Diplexer Design
Published 2024-12-01“…The diplexer offers insertion/return losses of about (0.44/0.74) dB/(0.45/1.12) dB for channel 1/channel 2, and (21.30/21.72) dB/(19.81/20.54) dB for channel 3/channel 4.…”
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Proteomics study of Mongolian medicine warm acupuncture in the treatment of p-chlorophenylalanine-induced insomnia in rats
Published 2024-12-01“…Differentially expressed proteins included albumin (ALB), Pro-MCH (PMCH), acetoacetyl-CoA synthetase (AACS), N-ethylmaleimide sensitive factor (NSF), potassium/sodium hyperpolarization-activated cyclic-nucleotide gated channel 4 (HCN4) and Ciapin1, which are important proteins for MMWA treatment of insomnia. …”
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Generation of human induced pluripotent stem cell (hiPSC) lines (UKMi009-A and UKMi011-A) harboring a homozygous and heterozygous HCN4 variant from a family with inherited sinus no...
Published 2025-08-01“…HCN4, as the predominant pacemaker current (If) in mammalian hearts, encodes the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 driving spontaneous cardiac rhythmicity. …”
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Autonomic nervous dysfunction in hamsters infected with West Nile virus.
Published 2011-05-01“…A subset of WNV infected cells was identified among cells with hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4) as a marker for cells in the sinoatrial (SA) and atrioventricular (AV) nodes. …”
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The Neglected Internodal Tract—A Cardiac Conduction System Structure Homologous to the Development and Regulation of the Sinoatrial Node
Published 2025-04-01“…Therefore, this paper aims to review the morphogenesis, development, and function of ITs, focusing on the regulatory mechanisms of transcription factors (TFs), such as NK2 homeobox 5 (NKX2.5), SHOX homeobox 2 (SHOX2), hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), and T-box transcription factor 3 (TBX3) in the development and morphogenesis of ITs. …”
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Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.
Published 2022-06-01“…The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. …”
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OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning
Published 2024-09-01“…These tools enable users without background in image or data analysis to (1) segment single cells and nuclei and to detect organelles, (2) to measure cell size and the distance between detected organelles and the nucleus, (3) to measure intensities in the organelle channel plus one additional channel, (4) to measure radial intensity profiles of organellar markers, and (5) to plot the results in informative graphs. …”
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Channels of Stellar-mass Black Hole Formation
Published 2025-01-01“…The latter may be accompanied by a pulsational pair-instability supernova. Channel 4 is the only quiescent or “silent” scenario for which perhaps ∼5–15 M _⊙ black holes are left. …”
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Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant.
Published 2016-01-01“…CLIC4 (Chloride intracellular channel 4) belongs to a family of putative intracellular chloride channel proteins expressed ubiquitously in multiple tissues. …”
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