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19261
Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity
Published 2025-01-01“…Methods Genomic DNA of three laser micro-dissected tumor regions, including digestive tract surface, central bulk, and invasive front, was extracted from formalin-fixed paraffin-embedded sections of colorectal cancer patients. …”
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19262
Mesalazine for People with Diverticular Disease: A Systematic Review of Randomized Controlled Trials
Published 2018-01-01“…We searched MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov for studies published to July 2018. …”
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19263
Incidence and survival of skin melanoma in Puglia: A comparison with the rest of Italy
Published 2016-11-01“…Conclusions: Incidence of skin melanoma is higher in Puglia compared with the southern Italy pool and lower compared with the other three Italian macro-areas (central, north-western and north-eastern Italy),but there are not statistically significant differences. …”
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19264
Implementation strategies: lessons learned during an e-learning intervention to improve dietary behaviors and feeding practices in early childhood education and care
Published 2025-01-01“…The Nutrition Now project focusing on improving dietary habits during the first 1000 days of life. Central to the project is the implementation of an e-learning resource aimed at promoting feeding practices among staff and healthy dietary behaviours for children aged 0–3 years in ECEC. …”
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19265
Decoding gene expression dynamics in planktonic and biofilm cells of Streptococcus mutans: regulation and role of mutanofactin genes in biofilm formation
Published 2025-01-01“…This operon is governed by the TetR/AcrR-family regulator MufC and plays a central role in biofilm development, offering a novel perspective on the molecular basis of S. mutans biofilm formation and resilience.…”
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19266
Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation
Published 2025-01-01“…Candidate biomarkers were screened using machine learning algorithms combined with 12 cytoHubba algorithms, and a diagnostic model for T2DM-related MAFLD was constructed and evaluated.The CIBERSORT method was used to investigate immune cell infiltration in MAFLD and the immunological significance of central genes. Finally, we collected whole blood from patients with T2DM-related MAFLD, MAFLD patients and healthy individuals, and used high-fat, high-glucose combined with high-fat cell models to verify the expression of hub genes.ResultsDifferential expression analysis and WGCNA identified 354 genes in the MAFLD dataset. …”
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19267
Early changes of peripheral circulating immune subsets induced by PD-1 inhibitors in patients with advanced malignant melanoma and non-small cell lung cancer
Published 2024-12-01“…In detail, CD4 + and CD8 + T cells were assessed according to their subtypes, such as central memory T cells (TCM), effector memory T cells (TEM), and naïve T cells (TN). …”
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19268
Microperimetry as a tool to assess retinal functional parameters in patients with recurrent macular hole
Published 2020-06-01“… Pirogov National Medical Surgical Center, Moscow, Russian Federation</b> </p> <p> <i><b>Aim</b>: to assess functional parameters of the central retina using microperimetry in patients who underwent surgery for macular holes after prior procedures using free ILM flap peeling.…”
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19269
Comprehensive assessment of a nationwide simulation-based course for artificial life support.
Published 2021-01-01“…To reach high standards of patients' care, we created the first of its kind, National Education Centre for Artificial Life Support (NEC-ALS) in 40 million inhabitants' country in the Central and Eastern Europe (CEE). The role of the Center is to test and promote the novel or commonly used procedures as well as to develop staff skills on management of patients needing ECMO.…”
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19270
Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis
Published 2024-02-01“…The estimated network revealed that suicidal ideation, plans and attempts were collectively associated with a history of self-harm, sleep problems, childhood abuse, school bullying and victimisation. Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse. …”
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19271
Supervised vs. Self-Managed Exercise Therapy for Improving Shoulder Function After Traumatic Dislocation and Sprain: A Systematic Review and Meta-Analysis
Published 2025-01-01“…Given the pivotal role of exercise therapy in restoring shoulder function, this study systematically reviews the literature on the comparative effectiveness of supervised versus self-managed exercise therapy following acute shoulder trauma. PubMed, Cochrane CENTRAL, Embase, Web of Science, and Science Direct were searched up to 13 December 2024. …”
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19272
Impact of subgingival periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome: a systematic review of randomized clinical trials
Published 2025-01-01“…A search was conducted in eight databases (PubMed, EMBASE, CINAHL, LILACS, Scopus, WoS Core Collection, Dentistry & Oral Science Source, and Cochrane Central) on June 20, 2023. Risk of bias was assessed using the Cochrane RoB 2 tool, and evidence certainty was evaluated following GRADE guidelines. …”
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19273
Sulfosalts and Sulfates in the Epithermal Au-Ag-Te Emmy Deposit (Khabarovsk Territory, Far East of Russia): Implications for the Mineralization Process
Published 2025-01-01“…Element mapping of the studied APS mineral grains indicated three distinct areas recording the evolution of the hydrothermal system in the Emmy: an oscillatory-zoned margin enriched in sulfur, lead, and barium, corresponding to the late influx of IS state fluids related to gold and tellurides; an intermediate part, which is leached and corresponds to the HS mineralization stage; and the central part of the grains, which is enriched in cerium, calcium, and strontium, resulting from a replacement of magmatic apatite in the pre-ore alteration stage. …”
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19274
Analysis of gene expression difference and biological process in chorionic villi of unexplained recurrent spontaneous abortion
Published 2024-12-01“…The PPI analysis revealed that the hub genes FCGR3A, TLR2, BTK, CLEC7A and CD163 were centrally located in the network cluster which were composed of the proteins encoded by differentially expressed genes associated with RSA. …”
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19275
Prevalence and determinants of unintended pregnancy among rural reproductive age women in Ethiopia
Published 2025-01-01“…Never had media exposure (AOR: 2.67, 95%CI 1.48, 4.83), don’t have work (AOR: 0.33, 95%CI 0.21, 0.52), being from household size of one to three (AOR: 0.44 95%CI 0.2, 0.96), being primiparous (AOR: 0.41, 95%CI 0.17, 0.99), women from poor families (AOR: 2.4, 95%CI 1.24, 4.56), lacking the intention to use contraceptive (AOR: 0.24, 95%CI 0.14, 0.44) were individual-level factors significantly associated with unintended pregnancy. Women from large central region (AOR: 4.2, 95%CI 1.19, 14.62) and being from poor community wealth status (AOR: 4.3, 95%CI 1.85, 10.22) were community-level factors statistically associated with unintended pregnancy. …”
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19276
Evaluation of commercial traits in the accessions of Medicago sativa L. from Asia Minor
Published 2019-02-01“…The place of origin for the identified local accessions had been Central Anatolia, with its continental climate. These accessions are valuable breeding sources with noteworthy commercial traits. …”
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19277
Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions
Published 2025-01-01“…Abbreviations: AD, Alzheimer's disease; NVU, Neurovascular unit; CNS, Central Nervous System.…”
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19278
Diagnostic Value of Sodium, White Blood Cell, Neutrophil Levels; White Blood Cell/Sodium and Neutrophil/Sodium Ratios in Appendicitis in Pediatric Patients
Published 2024-10-01“…Although clinical and imaging modalities play a central role in disease diagnosis, laboratory markers, such as white blood cell (WBC) count, neutrophil count, and electrolyte disturbances, particularly sodium levels, have been explored as potential indicators of disease severity. …”
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19279
Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis
Published 2025-01-01“…BackgroundSepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. The erythropoietin-producing hepatocellular carcinoma (Eph)A2 receptor is associated with increased vascular permeability; however, the developmental endothelial locus-1 (Del-1), has contrasting effects on endothelial function. …”
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19280
Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis
Published 2025-01-01“…ABSTRACT Chronic tinnitus is a central nervous system disorder. Currently, the effects of gut microbiota on tinnitus remain unexplored. …”
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