A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…VVL-m12 therapy induced increased intratumoral infiltration of CD4+ and CD8+ T cells and was able to clear tumor at early time points via increased induction and infiltration of effector T cells and central memory T cells (TCM). In addition, VVL-m12 increased dendritic cell activation, induced polarization of M2 macrophages towards an M1 phenotype, and inhibited tumor angiogenesis in vivo. …”
Get full text

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals by Camila Oliveira, Erika Aparecida Silveira, Lorena Rosa, Annelisa Santos, Ana Paula Rodrigues, Carolina Mendonça, Lucas Silva, Paulo Gentil, Ana Cristina Rebelo

“…Among the cardiovascular risk variables studied, insulin resistance and central adiposity showed the greatest influence on cardiac autonomic modulation of obese, increasing the risk for cardiovascular disease.…”
Get full text

Toward autism spectrum disorders and Williams-Beuren syndrome co-occurrence condition in Tunisian patients: Genetic insights by Rim Khelifi, Afef Jelloul, Houda Ajmi, Wafa Slimani, Sarra Dimassi, Khouloud Rjiba, Manel Dardour, Moez Gribaa, Ali Saad, Soumaya Mougou-Zerelli

“…Further analysis of the extended region deletion identified a gene closely located in the deleted region, the HIP1 gene, involved in the central nervous system trafficking protein.DiscussionThe recurrent deletion in WBS, as well as the mirror duplication, may contribute to ASD development in some cases, suggesting a potential involvement of the ASD genes pathway in this region. …”
Get full text

Healthy Eating Index-2015 and Dietary Total Antioxidant Capacity as Predictors of Prediabetes: A Case-Control Study by Jamal Rahmani, Karim Parastouei, Maryam Taghdir, Heitor O. Santos, Farinaz Hosseini Balam, Mohsen Saberi Isfeedvajani

“…The overall dietary quality, as well as the dietary total antioxidant capacity (DTAC), deserves central attention in the management of borderline high glucose levels since nonpharmacological strategies are imperative in this regard. …”
Get full text

How much water vapour does the Tibetan Plateau release into the atmosphere? by C. Zheng, L. Jia, G. Hu, M. Menenti, M. Menenti, J. Timmermans

“…Different products showed different patterns of spatiotemporal variability, with large differences in the central to western TP. The multi-year and multi-product mean ET in the TP was 333.1 <span class="inline-formula">mm yr⁻¹</span>, with a standard deviation of 38.3 <span class="inline-formula">mm yr⁻¹</span>. …”
Get full text

Integrated analysis of the transcriptome and hormone metabolome elucidates the regulatory mechanisms governing walnut bud germination by Kai Zhao, Xiaofan Wu, Bo Liang, Shuang Gao, Jieyan Yang, Yan Bai, Yaru Wang, Xin Tian, Fang Wang, Xiuqing Yang

“…Our analysis also revealed that genes from various transcription factor families are central within the co-expression network, indicating their significant roles in the bud germination process. …”
Get full text

Functional and Anatomical Outcomes of Pars Plana Vitrectomy for Lamellar Macular Hole: Long-Term Follow-Up by Fabrizio Giansanti, Cristina Nicolosi, Giuseppe Ruben Barbera, Giulio Vicini, Flavia Lucarelli, Edoardo Traniello Gradassi, Vittoria Murro, Gianni Virgili, Daniela Bacherini

“…Outer retinal disruption was present in 31.25% of LMH cases. The average central foveal thickness (CFT) measured 183.68 ± 61.73 microns. …”
Get full text

Topographic correlation of microperimetry with foveal microstructure characteristics in idiopathic epiretinal membrane patients with an ectopic inner foveal layer by Qianqian Wang, Congyao Wang, Yihua Su, Fenfen Yu, Tingting Chen, Xia Dong, Pengxia Wan

“…Results Group 2 exhibited reduced light sensitivity across all parameters of microperimetry compared to Group 1 (P < 0.001). Additionally, the central foveal thickness, the percentage of ellipsoid zone disruption, and the foveal avascular zone area were significantly lower in Group 1 than in Group 2 (all P < 0.005). …”
Get full text

Three-Year Outcomes of Patients with Neovascular Age-Related Macular Degeneration Treated with Aflibercept under the National Health Insurance Program in Taiwan by Kang-Jung Lo, Jin-Yu Chang, Hsin-Yi Chang, Shih-Hwa Chiou, De-Kuang Hwang, Shih-Jen Chen

“…Visual acuity (VA) and central macular thickness (CMT) were recorded for 3 years. …”
Get full text

Candida Bloodstream Infection: Changing Pattern of Occurrence and Antifungal Susceptibility over 10 Years in a Tertiary Care Saudi Hospital by Nawaf Alkharashi, Sameera Aljohani, Laila Layqah, Emad Masuadi, Waleed Baharoon, Hamdan AL-Jahdali, Salim Baharoon

“…Use of broad spectrum antibiotics (82%), prior ICU admission (60%) and use of central venous catheters (58%) were the most prevalent predisposing factors of candidemia. …”
Get full text

Sistema de espaços livres públicos na expansão urbana e suas múltiplas temporalidades e escalas by Luciana Sobis Alves, Sergio Torres Moraes

“…Os espaços públicos implantados no núcleo central durante o período de Colonização (1909-1930) dispõem de melhor qualidade e conexão, ao contrário daqueles da Expansão (1990-2020), que estão nas atuais bordas periféricas da cidade. …”
Get full text

How does the concentration of spatial allocation of urban construction land across cities affect carbon emission intensity in China? by Hui Yang, Cheng Chen, Jingye Li, Min Li, Stefan Sieber, Kaisheng Long

“…The heterogeneity analysis showed that the impact of CSA on CEI followed a U-shaped pattern in both the developed and developing regions, as well as in the eastern, central and western regions. Additionally, the analysis revealed a similar pattern in both the resource- and non-resource-based cities. …”
Get full text

Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos by Anne E. Sanders, Jianwen Cai, Martha L. Daviglus, Olga Garcia-Bedoya, Gary D. Slade

“…Setting: From 2008—2011, HCHS/SOL recruited 16,415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centers located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY. …”
Get full text

Ecological impacts of single-axis photovoltaic solar energy with periodic mowing on microclimate and vegetation by Yudi Li, Yudi Li, Alona Armstrong, Alona Armstrong, Christopher Simmons, Noah Z. Krasner, Noah Z. Krasner, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez

“…In the state of California’s Great Central Valley (United States), we developed a novel experimental framework to characterize five distinct “micro-patches” that capture the full spectrum of microclimate and vegetation zones modulated by the tracking PV system and O&amp;M. …”
Get full text

Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review by Grace Zhao, Sarah Chondon, Clint Gray, Sheridan Gentili, Meagan Stanley, Timothy RH Regnault

“…Methods: A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed up to October 4, 2024, to identify animal and human studies that focused on maternal fructose consumption pre- and during pregnancy on hepatic and whole-body adiposity in the mother, fetus, and offspring. …”
Get full text

Evaluation of the impact of PEPFAR transition on retention in care in South Africa’s Western Cape Province by J Chiliza, R Laing, F G Feeley, A T Brennan

“…City of Cape Town combined with Western Cape Government health facilities showed a substantial decrease (–6.1%; 95% CI –10.6 - –1.7%), while community health clinic (v. central day clinics) declined (–6.4; 95% CI –10.6 - –2.1%) in RIC. …”
Get full text

Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies by Atri Das, Swarnali Khan, Syamal Roy, Shantanabha Das

“…Phytochemicals may prove useful in alleviating post-COVID complications associated with kidney injury, and central nervous system complications, as well. Plant-derived compounds are usually cheaper and have fewer side effects. …”
Get full text

Establishing trust through home visits during pregnancy: a realist evaluation of a Danish breastfeeding support intervention by Anne Kristine Gadeberg, Ingrid Maria Susanne Nilsson, Ulla Christensen, Marie Honoré Jacobsen, Henriette Knold Rossau, Sarah Fredsted Villadsen

“…In realist terms, our central mechanism of change, the establishment of trust, had optimal conditions for success in the contextual setting of the pregnancy home visit where there was time, peace, undisturbed conversations, mental capacity to reflection, and a perceived more even power balance between the family and the health visitor which resulted in a range of positive outcomes. …”
Get full text

The clinical role of blood coagulation and platelet receptors gene allelic variants in development of Wilson’s disease by T. P. Rozina, S. V. Fastovets, E. E. Starostina, L. M. Samokhodskaya, T. N. Krasnova

“…Frequency of 5G allele of plasminogen activator inhibitor gene PAI-675 5G/4G in the group with neurologic symptoms was lower (41.17%), than in the group without symptoms of central nervous system (CNS) involvement (49.02%) (odds ratio - OR: 1.374; 95% confidence interval - CI: 0.739-2.553). …”
Get full text

The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease with demyelinating inflammatory characteristics. …”
Get full text