Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

“…However, chronic inflammation can be harmful and significantly contribute to the development and progression of chronic diseases, with macrophage-mediated responses being central to these processes. This study presents “SBR-Pel,” a new therapeutic blend of Shinbaro tab (SBR), a traditional herbal formula, and pelubiprofen (Pel), a non-steroidal anti-inflammatory drug, and investigated their combined anti-inflammatory effects to create a treatment that both improves efficacy and reduces side effects. …”
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Sources, Compositions, and Health Risks of PM2.5-bound PAHs at the Rural Area along with the “Coal to Gas” Law by Zhiyong Li, Ziyuan Yue, Wenjia Zhu, Wenquan Liu, Jintao Gao, Jiaqiang Zhang, Ziyi Zhan, Lan Chen, Huiying Gao, Jihong Wei

“…Here, we deployed an intensive observation in winter of 2020 at a rural site in the central area of the Beijing-Tianjin-Hebei (BTH) region. …”
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Effectiveness of the User-Centered “Healthcare CEO” App for Patients With Type 1 Diabetes Transitioning From Adolescence to Early Adulthood: Protocol for a Randomized Controlled Tr... by Yueh-Tao Chiang, Hsing-Yi Yu, Pei-Kwei Tsay, Chi-Wen Chen, Chi-Wen Chang, Chien-Lung Hsu, Fu-Sung Lo, Philip Moons

“…Participants will be randomly assigned to either the experimental or control group through central randomization. The intervention will be implemented using the Healthcare CEO app, which consists of 11 interfaces. …”
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Gliomas Difusos do Adulto: Prevalência da Mutação IDH1 em um Hospital Universitário by Vitor Bonk Rizzo, Michelle Arrata Ramos, Eduardo Morais de Castro, Pedro Helo dos Santos Neto, Samya Hamad Mehanna

“… Introdução: Os gliomas pertencem aos tumores primários do sistema nervoso central e são neoplasias originárias nas células da glia. …”
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Páginas proibidas: censura de livros no Brasil by Renata Teodoro Viana, Enrique Muriel-Torrado, Jorge Moisés Kroll do Prado

“…Os resultados apontam a ocorrência de censura de livros no país, em especial no âmbito da biblioteca escolar, sendo perpetrada principalmente por autoridades da instituição e por pais/responsáveis, em sua maioria entre 2022 e 2023. A motivação central identificada reside na consideração de que a obra é inadequada para o público infantil e/ou adolescente. …”
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Development of a Solar-Powered Edge Processing Perimeter Alert System with AI and LoRa/LoRaWAN Integration for Drone Detection and Enhanced Security by Mateo Mejia-Herrera, Juan Botero-Valencia, José Ortega, Ruber Hernández-García

“…Edge processing is a trend in developing new technologies that leverage Artificial Intelligence (AI) without transmitting large volumes of data to centralized processing services. This technique is particularly relevant for security applications where there is a need to reduce the probability of intrusion or data breaches and to decentralize alert systems. …”
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Imagen de China en medios latinoamericanos: análisis periodístico de la Franja y la Ruta by Shiyang Liu, Guyu Zhu

“…Los hallazgos revelaron que: a nivel alto, los artículos periodísticos se enfocaron principalmente en temas económicos, diplomáticos y políticos; en el nivel medio, estos tres temas utilizaron un conjunto de recursos, tales como eventos anteriores y evaluaciones, para resaltar el tópico central; a nivel bajo, los artículos emplean fundamentalmente metáforas, cifras, comparaciones y citas con el objetivo de aumentar la credibilidad e intensificar el tema abordado. …”
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Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019 by Xinyue Yang, Zhiqiang Zhang, Jiayi Sun, Wenjuan Zhang

“…The corresponding age-standardized mortality rates (ASMR) and age-standardized DALYs rates (ASDR) were both in a decreasing trend with estimate of the annual percentage change (EAPC) of -1.38 (-1.42 – -1.34) and -1.43 (-1.47 – -1.38). Central Asia has the highest ASMR (16 per 100000, 95% uncertainty interval, UI: 12.8–19.4), and Oceania has the highest ASDR (323.2 per 100000, 95% UI: 228.9–443.1 per 100000) in 2019. …”
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Mortalidad y morbilidad del paciente adulto maduro ingresado en la unidad de cuidados intensivos by Alberto García Gómez, Yasmani Gámez Pérez, Pedro Julio García Alvarez, Juan Carlos Pradere Pensado, Serafin Noa Cordero, Jorge Javiel Cedeño Cabrera

“…Se calcularon distribuciones de frecuencias, medidas de tendencia central; y las pruebas de jicuadrado y t de Student, con un nivel de significación del 5 %. …”
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Correlation between depressive symptoms and cognitive function in middle-aged and elderly population in China: an analysis of CHARLS baseline data by Yuchao SUN, Jing FENG, Zihui LEI, Ge QU, Xinyan LI, Yong GAN

“…The results of multiple linear stepwise regression showed that being female (B = – 0.31), being older (B60 – 69 years = – 0.19; B70 – 79 years = – 1.18; B80 – 89 years = – 2.12; B ≥ 90 years = – 3.66), living in central and western regions (Bcentral = – 0.36; Bwestern = – 0.57), smoking (B = – 0.15), and having depressive symptoms (Bmild to moderate = – 0.90; Bsevere = – 1.51) were risk factors for cognitive decline; further stratified analysis revealed that depressive symptoms had a significant negative impact on cognitive function in middle-aged and older adults across gender, residential area, and region of life, with higher levels of depression associated with poorer cognitive function. …”
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Earliness and morphotypes of common wheat cultivars of Western and Eastern Siberia by S. E. Smolenskaya, V. M. Efimov, Y. V. Kruchinina, B. F. Nemtsev, G. Y. Chepurnov, E. S. Ovchinnikova, I. A. Belan, E. V. Zuev, Chenxi Zhou, V. V. Piskarev, N. P. Goncharov

“…However, since none of the tested cultivars had the dominant Vrn-D1 gene typical of the regions of China and Central Asia bordering Siberia, it can be considered as an additional argument in favor of the European origin of Siberian common wheat cultivars. …”
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Active and Passive Smoking as Catalysts for Cognitive Impairment in Rural Indonesia: A Population-based Study by Faizal Muhammad, Afifah Syifaul Ummah, Farida Aisyah, Rivan Danuaji, Diah Kurnia Mirawati, Subandi Subandi, Baarid Luqman Hamidi, Ervina Arta Jayanti Hutabarat, Reviono Reviono, Yulie Erida Nur Rahmawati, Isa Ridwan

“…Methods: This population-based two-year survey was conducted in four rural public health centers from 2021 to 2023 in Central Java, Indonesia, each center caters to approximately 30 000 people. …”
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Prediction of drought-flood prone zones in inland mountainous regions under climate change with assessment and enhancement strategies for disaster resilience in high-standard farml... by Yongheng Shen, Qingxia Guo, Zhenghao Liu, Yanli Shen, Yikun Jia, Yuehan Wei

“…The overall findings indicate that: (1) Precipitation (Pr) and the Standardized Precipitation-Evapotranspiration Index (SPEI) have increased in recent years, with Pr expected to continue rising until 2035. (2) The integration of historical data with the predictions from the PSO-LSTM-GAT model reveals significant spatial overlap between historical and future disaster-prone areas and intensive cropland, especially in the central region. (3) Compared to single models, the PSO-LSTM-GAT model demonstrates significantly improved performance and precision in predicting drought- and flood-prone areas. (4) Through the FDRA integrated adjustment mechanism, 6.6668 km² of unsuitable land was identified, and 6.7349 km² of high-quality land was selected as the proposed site for the next round of HSF projects. …”
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Gap analysis of maternity service quality and associated factors at a maternity hospital in northwest Iran: a cross-sectional survey using SERVQUAL and HEALTHQUAL questionnaires by Parnian Rahimi, Farzaneh Miri, Alireza Hajizadeh, Azadeh Anbari, Jafar Sadegh Tabrizi, Edris Kakemam

“…Abstract Background Concerning maternity service, the mother’s quality assessment is central because emotional, cultural, and respectful support is vital during labour and the delivery process. …”
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Neuropsychological features of patients of reproductive age diagnosed with breast cancer at the stage of surgical treatment using xenon-oxygen therapy by D. A. Rozenko, A. I. Shikhlyarova, L. N. Vaschenko, N. N. Popova, Yu. Yu. Arapova, A. Yu. Ardzha, A. A. Korobov

“…The functional state of the central nervous system in all patients was assessed by the parameters of the electroencephalography (EEG) bioelectrical activity. …”
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Factors accounting for limited sexual reproduction in a long-lived unisexual plant species by Irene Bisang, Flavien Collart, Flavien Collart, Alain Vanderpoorten, Lars Hedenäs

“…Successful sexual reproduction, in terms of sporophyte occurrence, was confined to central Sweden. It was predicted by intermediate to increasing precipitation seasonality and intermediate temperature values.DiscussionDespite a high level of sex-expression, and no significant differences of niche preference between males and females, sporophyte occurrences were rare. …”
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Identifying high-risk population segments for underweight, overweight, and obesity among reproductive-age women in sub-Saharan Africa by Amare Abera Tareke, Amare Abera Tareke, Anissa Mohammed, Amare Muche, Yeshimebet Ali

“…Employment was protective against all three malnutrition forms.ConclusionIncreased age, wealth index, not-breastfeeding status during the survey, contraceptive use, higher parity, marital status, urban residency, and living in southern or central Africa are associated with higher odds of increased BMI and lower odds of underweight. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-traumatic cause of disability in young adults. …”
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Metabolic and molecular Characterization, following dietary exposure to DINCH, Reveals new Implications for its role as a Metabolism-Disrupting chemical by Sontje Krupka, Alix Sarah Aldehoff, Cornelius Goerdeler, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Kristin Schubert, Nora Klöting, Martin von Bergen, Matthias Blüher

“…Proteomic profiling of serum, adipose and liver tissues revealed changes in pathways related to central energy metabolism and immune response, highlighting the systemic impact of DINCH, potentially on inflammatory processes. …”
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Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice by Alexandra O. Strohm, Sadie Oldfield, Eric Hernady, Carl J. Johnston, Brian Marples, M. Kerry O'Banion, Ania K. Majewska

“…Experiments in rodent models show that these adverse neurological effects are in part due to functional changes in microglia, the resident immune cells of the central nervous system. Increasing evidence suggests that experimental manipulation of microglial signaling can regulate radiation-induced changes in the brain and behavior. …”
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