Therapeutic Efficacy of Intranasal <i>N</i>-Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice by Hiroshi Nango, Ai Takahashi, Naoto Suzuki, Takumi Kurano, Saia Sakamoto, Taiki Nagatomo, Toyofumi Suzuki, Takanori Kanazawa, Yasuhiro Kosuge, Hiroko Miyagishi

“…<b>Background/Objectives</b>: We previously demonstrated that the intranasal administration of cell-penetrating Tat peptide-modified carrier, PEG-PCL-Tat, improves drug delivery to the central nervous system. This study aimed to evaluate the potential of the post-onset intranasal administration of <i>N</i>-acetyl-L-cysteine (NAC) combined with PEG-PCL-Tat (NAC/PPT) for neuropathic pain. …”
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LTA4H rs2660845 association with montelukast response in early and late-onset asthma. by Cyrielle Maroteau, Antonio Espuela-Ortiz, Esther Herrera-Luis, Sundararajan Srinivasan, Fiona Carr, Roger Tavendale, Karen Wilson, Natalia Hernandez-Pacheco, James D Chalmers, Steve Turner, Somnath Mukhopadhyay, Anke-Hilse Maitland-van der Zee, Esteban G Burchard, Maria Pino-Yanes, Simon Young, Glenda Lassi, Adam Platt, Colin N A Palmer, PiCA Consortium

“…Leukotrienes play a central pathophysiological role in both paediatric and adult asthma. …”
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Automatic Characterization of Prostate Suspect Lesions on T2-Weighted Image Acquisitions Using Texture Features and Machine-Learning Methods: A Pilot Study by Teodora Telecan, Cosmin Caraiani, Bianca Boca, Roxana Sipos-Lascu, Laura Diosan, Zoltan Balint, Raluca Maria Hendea, Iulia Andras, Nicolae Crisan, Monica Lupsor-Platon

“…Multiparametric magnetic resonance imaging (mpMRI) holds a central role in PCa assessment; however, it does not have a one-to-one correspondence with the histopathological grading of tumors. …”
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The Utah Population Database. A Model for Linking Medical and Genealogical Records for Population Health Research by Ken R. Smith, Alison Fraser, Diana Lane Reed, Jahn Barlow, Heidi A. Hanson, Jennifer West, Stacey Knight, Navina Forsythe, Geraldine P. Mineau

“…Demographers and other social scientists are increasingly using the UPDB to study issues such as trends in fertility transitions and shifts in mortality patterns for both infants and adults. A central component of the UPDB is an extensive set of Utah family histories, in which family members are linked to demographic and medical information. …”
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Evidencia psicométrica y confirmatoria de la responsabilidad social empresarial en México by Osiris María Echeverría Ríos, Jesús Alberto Montalvo Morales, Yazmín Guadalupe Cervantes Ávila

“…A pesar de ello, el hallazgo central implica que la perspectiva económica no impacta en el consumidor de la zona noreste de México, a dife-rencia de estudios precedentes. …”
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Investigating the effectiveness of whole-virus, protein-based, and vector-based SARS-CoV-2 vaccines on the rates of COVID-19 infection, hospitalization, and mortality: a historical... by Davoud Tanbakuchi, Nadiasadat Taghavi Razavizadeh, Maryam Salari, Ehsan Mosa Farkhani, Mohammad Taghi Shakeri, Seyed Saeed Tabatabaee, Rasoul Raesi, Vahid Ghavami

“…Quantitative data were characterized using measures of central tendency and dispersion, while the risks of infection, hospitalization, and mortality were assessed for each type of vaccine. …”
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Crônicas de dois tempos: a representação LGBT nas décadas de 1990 e 2010 nas minisséries Crônicas de San Francisco by Kaippe Arnon Silva Reis, Ana Luisa de Castro Coimbra

“…A partir desta análise, constatou-se que, se na primeira minissérie retratar homens gays brancos e uma personagem central trans parecia ser suficientemente disruptivo, nos anos 2010, para evocar diversidade foi necessário não apenas multiplicar as identidades desviantes como também pensar em um quase infinito número de interseccionalidades para que se pudesse dizer que o programa é diverso – com pessoas com deficiência, casais interraciais, pessoas vivendo com HIV e pessoas de diferentes localidades, cores e corpos.…”
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Risks to human and animal health from the presence of bromide in food and feed by EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford

“…The critical effects of bromide in experimental animals are on the thyroid and central nervous system. Changes in thyroid hormone homeostasis could result in neurodevelopmental toxicity, among other adverse effects. …”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…However, those have yet to be explored aiding diagnosis for tumours of the central nervous system (CNS) other than high-grade gliomas (HGG). …”
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The impact of land use transition on ecosystem service value in Lixiahe area: Multi-scenario simulation based on Markov-FLUS model by CHEN Xinwei, LI Hongbo, ZHANG Wenbo, GE Xiaoping

“…The main form of land use type transformation was from cultivated land to wetland or construction land, and the active transformation areas were concentrated in the central and eastern and western boundary areas. (2) The ecosystem service value of the study area in 1990, 2005 and 2020 showed a year-on-year increasing trend, and the spatial pattern was relatively stable. …”
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Mesenchymal stem cell and exosome-based therapy for liver diseases: can it overcome conventional therapeutic inconsistencies? by Zahid Hussain

“…In this review, we analyze the mechanism and causative factors of liver diseases, conventional mode, and alternative therapeutic options. The central to liver diseases are immune dysregulation, hence bioactive agents with immunomodulatory properties should be searched and exploited to meet therapeutic needs. …”
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Impact of the COVID-19 pandemic on cerebral venous sinus thrombosis in China: a comparative study by Xiaoming Zhang, Kun Fang, Duo Lan, Xiangqian Huang, Xunming Ji, Ran Meng, Da Zhou

“…Poor outcomes were associated with central nervous system (CNS) infection, oral contraceptive use or hormone replacement therapy (HRT), hematologic disorders, anemia, and prothrombotic conditions. …”
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A Study Comparing Immunohistochemistry, Fluorescence in situ hybridization, GeneXpert® Breast Cancer STRAT4 Assay for Determining Hormone Receptor, Human Epidermal Growth Factor Re... by Rajaa El Aje, Abdellah Naya, Ayoub Khoaja, Younes Zaid, Mounia Oudghiri, Jodi Weidler, Mehdi Karkouri

“…The simple Kappa coefficient was, for ER, 0.830 (P < 0.0001), 0.565 (P < 0.0001) for PR, 0.838 (P < 0.0001) for HER2-IHC, 0.771 (P < 0.0001) for HER2 IHC+FISH and, for, Ki67, 0.458 (P < 0.0001); Conclusions: We demonstrated globally a high concordance between centrally assessed IHC, IHC+FISH and mRNA measurements of ER/ESR1 and HER2/ERBB2, and a moderate agreement between PR/PGR and Ki67/MKi67. …”
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How interventions to maintain services during the COVID-19 pandemic strengthened systems for delivery of maternal and child health services: a case-study of Wakiso District, Uganda by Steven Ndugwa Kabwama, Rhoda K. Wanyenze, Neda Razaz, John M. Ssenkusu, Tobias Alfvén, Helena Lindgren

“…Methods This was a descriptive case study conducted in Wakiso District in central Uganda. It included 21 nurses and midwives as key informants and 32 mothers in three focus group discussions. …”
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Alterations of attention and impulsivity in the rat following a transgenerational decrease in dietary omega-3 fatty acids by Joachim Hauser, Ewelina Stollberg, Andreas Reissmann, Ivo Kaunzinger, Klaus W. Lange

“…Polyunsaturated fatty acids (PUFAs), particularly the omega-3 PUFAs, are thought to be involved in neuronal processes, to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system functioning. The present study investigated the effects of nutritional omega-3 PUFAs on attentional functions and impulsive behavior in Wistar rats. …”
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Evaluation of Shear Bond Strength of Resin-Based Composites to Biodentine with Three Types of Seventh-Generation Bonding Agents: An In Vitro Study by Huda Abbas Abdullah, Zahraa Abdulaali Al-Ibraheemi, Zanbaq Azeez Hanoon, Julfikar Haider

“…Forty-eight acrylic blocks having central holes with a nominal diameter of 4 mm and a depth of 2 mm were prepared. …”
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Otimização de filmes de acetato de celulose incorporado com nanocristais de celulose e aroma de salada de frutas by Amanda Lélis de Souza, Bárbara Teixeira Gomes, Taila Veloso de Oliveira, Nilda de Fatima Ferreira Soares

“…Foram geradas 12 formulações utilizando o método de Delineamento Composto Central Rotacional (DCCR), sendo realizadas as análises de umidade e transparência. …”
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Transitar desde la Escuela al Mercado Laboral: Un Enfoque Basado En la Educación para el Trabajo by Tania Mateos Blanco

“…La primera cuestión se centra en pensar sobre el trabajo como valor humano y actividad de la que podemos obtener una serie de bienes centrales y que esto redunde, a nivel existencial, en algo con sentido para nuestras vidas. …”
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Digital Gangrene: An Unusual Manifestation of Non-Hodgkin Lymphoma by Muhammad Shoaib Momen Majumder, Shamim Ahmed, Tajkia Haque, Syed Atiqul Haq, Saumitra Chakravarty, Md. Abu Shahin, Din-E-Mujahid Mohammad Faruque Osmany, Johannes J. Rasker

“…The clinical picture varies from indolent to aggressive presentation and nodal (lymphadenopathy) to extranodal (central nervous system, gastrointestinal, cutaneous plaque, or ulcer) involvement. …”
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The experience of approbation and empirical substantiation of the ecopsychological model of subjectivity development in educational practice by Irina V. Plaksina

“…The choice of the model is due to the need to solve the central task of educational practice stated by the Federal State Educational Standard at all levels - the development of students ability to be a subject of educational activity. …”
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