Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation by Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio

“…Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by autoimmune destruction of the myelin sheath, leading to irreversible and progressive functional deficits in patients. …”
Get full text

The Efficacy of Adalimumab Treatment in Pediatric Non-Infectious Uveitis: A Retrospective Cohort Study by Kübra Özdemir Yalçınsoy, Osman Özen, Yasemin Özdamar Erol, Pınar Çakar Özdal

“…The efficacy of ADA in patients treated for at least 1 year after failure of conventional immunosuppressive treatment was evaluated by comparing the best corrected visual acuity (BCVA), severity of intraocular inflammation, uveitis flare-ups, topical and systemic corticosteroid (CS) use, and central macular thickness (CMT) values before and after ADA treatment. …”
Get full text

Jogos digitais gamificados aplicados na educação infantil: uma revisão integrativa by Priscila Íris de Castro, Cristiane Moraes Marinho

“…As fontes foram consultadas por meio da base de dados no portal Periódicos CAPES, o recorte temporal da pesquisa abrangeu publicações entre 2020 a agosto de 2024, disponíveis para download em língua portuguesa que discute conceitos, teorias, e práticas relevantes ao tema central da pesquisa. A sistematização e tabulação dos resultados foram apoiadas pela elaboração de quadros e tabelas, permitindo uma visualização clara dos dados coletados. …”
Get full text

Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications by Vincenzo Salpietro, Agata Polizzi, Gabriella Di Rosa, Anna Claudia Romeo, Valeria Dipasquale, Paolo Morabito, Valeria Chirico, Teresa Arrigo, Martino Ruggieri

“…The development and maturation of the central nervous system (CNS) through childhood is tightly regulated by intrinsic, paracrine, endocrine, and external modulators, and perturbations in any of these factors, including those related to adrenal hormone imbalance, could result in consequences that affect the structure and function of the paediatric brain. …”
Get full text

Impact of the new hazard classes in the CLP regulation on EU chemicals legislation by Diana Kättström, Anna Beronius, Urban Boije af Gennäs, Christina Rudén, Marlene Ågerstrand

“…This action was a direct consequence of the EU’s Chemicals Strategy for Sustainability, which aims at strengthening the protection of human health and the environment, as well as reinforcing the CLP Regulation as the central piece of the chemicals legislation. This study examined the regulatory obligations triggered by these new hazard classes, as well as the existing obligations for endocrine disrupters and PBT/vPvB substances identified in other EU regulations. …”
Get full text

Distribution of Pupil Size and Associated Factors: Results from the Population-Based Gutenberg Health Study by Marian Kiel, Stephanie D. Grabitz, Susanne Hopf, Thomas Koeck, Philipp S. Wild, Irene Schmidtmann, Karl J. Lackner, Thomas Münzel, Manfred E. Beutel, Norbert Pfeiffer, Alexander K. Schuster

“…Optical biometry (Lenstar LS900, Haag-Streit, Koeniz, Switzerland) including measurements of physical pupil diameter, central corneal thickness, corneal curvature, anterior chamber depth, and axial length was performed under mesopic light conditions. …”
Get full text

Hydraulic Power Plant Machine Dynamic Diagnosis by Hans Günther Poll, José Carlos Zanutto, Walter Ponge-Ferreira

“…The way how the power plant owner has to operate its Francis machines, many times also determined by a central dispatcher, has a high influence on the fatigue life time of the machine components. …”
Get full text

Genetic polymorphism of local Abkhazian grape cultivars by E. T. Ilnitskaya, M. V. Makarkina, I. V. Stepanov, I. I. Suprun, S. V. Tokmakov, V. Ch. Aiba, M. A. Avidzba, V. K. Kotlyar

“…The territories of the subtropical zone of Georgia and the central part of Abkhazia belong to one of the centers of origin of the cultural grapevine. …”
Get full text

Investigation of the CO₂ Pre-Fracturing Mechanism for Enhancing Fracture Propagation and Stimulated Reservoir Volume in Ultra-Deep Oil Reservoirs by Liming Liu, Ran Ding, Enqing Chen, Cheng Zhang

“…This study investigates the CO₂ pre-fracturing process in ultra-deep sandstone reservoirs of the central Junggar Basin. A 3D geomechanical model was established using RFPA3D-HF based on rock mechanical parameters from laboratory experiments. …”
Get full text

Educational Policy of Kazakhstan in the Context of Youth Migration by V. Yu. Ledeneva, O. V. Lomakina, A. M. Dzhunusov, B. T. Begasilov

“…But even if there are such publications, then, as a rule, they are devoted to the analysis of youth migration in Central Asia in general. The relevance of the study is determined by the gradual expansion of educational contacts of Kazakhstan with other countries and the need to identify the competitive advantages of foreign educational systems over the national higher education system of Kazakhstan.The purpose of the article is to consider the main motives, causes and consequences of educational migration from Kazakhstan, to analyze the activities of the authorities and ways of regulating youth migration, develop new effective methods for regulating external migration processes and provide recommendations on minimizing the risks associated with the outflow of young people from the country.In order to identify the main trends and development of educational migration from Kazakhstan, the study was carried out on the basis of collecting information through a questionnaire, as well as its detailed processing and content analysis. …”
Get full text

D. M. Ovsianyko-Kulikovsky as an Orthologist: the Cognitive-evolutionary Coverage by Sergiy Popov

“…The main provisions of the cognitive-evolutionary theory of language are revealed, the essence of which involves the algorithm "perception → logic of thinking → logic of language" and one of the central concepts of which is the concept of superficiality of perception as an orientation to the closest, most noticeable features of phenomena, the categorization of which is often erroneous. …”
Get full text

Vazios urbanos, imóveis subutilizados e patrimônio by Raquel Osias Toscano Brito, Ivan Cavalcanti Filho

“…Os resultados alcançados contribuem para um entendimento melhor da atual situação do patrimônio histórico-arquitetônico e das dinâmicas que envolvem a área central com vistas à sua preservação, além de alertar para a premência de cumprimento da função social de imóveis localizados em área provida de infraestrutura e com potencial de utilização. …”
Get full text

Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery? by Elizabeth Cho, MD, Hanna House, MD, Andrew Marten, BS, Marina Feffer, MPH, Julie Agel, MA, John Scolaro, MD, Meir Marmor, MD, Ashley E. Levack, MD, MAS, OTA Classification & Outcomes Committee, James Kellam, MD, Gillian Soles, MD, Jarrod Dumpe, MD, Kyle Schweser, MD, Geoffrey Maracek, MD

“…The CDC SWC has notable limitations for patients with orthopaedic trauma, with ambiguity of classification assignment and decreased discriminatory ability within the central classes. While overall SWC is associated with infection, the relationship seems to be confounded by the effect of open versus closed fractures. …”
Get full text

Exceeding the limits of paediatric heat stress tolerance: the risk of losing a generation to climate inaction by Sulani Nyimbili, Anna Bershteyn, Alexander Azan, Oyinkansola O Babayode

“…Climate mitigation through GHG reductions is central to reducing harms to children and preventing the loss of a generation to climate change. …”
Get full text

Mechanical properties and piecewise constitutive model of fine sandstone in mining area of western China by Qing Wang, Dongxiao Zhang, Fei Han, Yongqiang Zhao, Pengfei Zhang, Feng Xiong

“…Abstract Owing to the differences in sedimentary environments in the mining areas of western China, the mechanical properties of rocks in this region are significantly different from those in the central and eastern regions. Therefore, uniaxial cyclic loading-unloading tests were conducted on fine sandstone found in many roof rocks to study the evolution laws of mechanical properties, deformation characteristics, acoustic emission (AE) parameters, and energy under cyclic loading and unloading conditions. …”
Get full text

Carbapenem resistance in the Dominican Republic: clinical characteristics, genotypic profiles, and risk factors by Ricardo Ernesto Hernández-Landa, Rita Rojas-Fermín, Anel Guzman-Marte, Katherine Peralta Agramonte, Missel María Jiménez Cedano, Surelly Alexandra Mora-Peralta, Patricia Sanrregré-Oven, Alfredo J. Mena Lora

“…CRE patients had longer hospital stays (mean 18.7 vs 4.6 days, P < 0.001), higher ICU admission rates (34.7% vs 3.6%, P < 0.001), and increased invasive procedure use (eg central venous catheters, 36.6% vs 5.4%, P < 0.001). …”
Get full text

Emilio B. Coutaret. Artista y agente cultural multifacético by Marcela Andruchow

“…Estas características agregan verosimilitud a las obras, cualidad compartida con los otros murales distribuidos en el espacio central del Museo.   …”
Get full text

Hydrothermal conditions dominated sensitivity and lag effect of grassland productivity in Yunnan Province, China: Implications for climate change by Yan Fang, Long Wan, Jing Tong, Guijing Li, Jing Pang, Enfu Chang, Linglan Chen, Zixuan Shi

“…The results indicated that grassland experienced a warming and drying trend, with an overall upward trend averaging 5.30 gC·m−2·a−1. Notably, the central Yunnan Plateau region boasted the highest productivity growth rate, reaching 7.67 gC·m−2·a−1. …”
Get full text

Can the digital economy foster advancements in the healthcare sector? — a case study using interprovincial data from China by Zhengqi Wei, Keke Wei, Jing Yang, Meilin Zhang, Feng Yang

“…The eastern region particularly benefits from the digital economy's enhancement of service levels, while the central and western regions see less impact. The digital economy enhances services by improving medical resource levels and promoting their coordinated development. …”
Get full text

Effectiveness of interventions for middle-aged and ageing population with neck pain: a systematic review and network meta-analysis protocol by Alison B Rushton, Nicola R Heneghan, Taweewat Wiangkham, Uchukarn Boonyapo, Piyameth Dilokthornsakul, Nattawan Phungwattanakul

“…Two independent reviewers will search key databases (AMED, CENTRAL, CINAHL, Embase, MEDLINE, PEDro and PsycINFO), grey literature, key journals and reference lists in May 2022. …”
Get full text