Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells by Vladimir F. Niculescu

“…Cells that can overcome senescence can proliferate as defective symmetric cell division, paving the way for malignancy and polyploid giant cancer cell cancers. …”
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Single cell suppression profiling of human regulatory T cells by Jonas Nørskov Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James B. Wing

“…To overcome this limitation, we here develop ‘single cell suppression profiling of human Tregs’ (scSPOT). scSPOT uses a 52-marker CyTOF panel, a cell division detection algorithm, and a whole PBMC system to assess the effect of Tregs on all other cell types simultaneously. …”
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Microscopic origin of the spatial and temporal precision in biological systems by Anupam Mondal, Anatoly B. Kolomeisky

“…In cell-size regulation, it is argued that a balance between stochastic cell growth and cell division processes leads to a narrow distribution of cell sizes. …”
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Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine by John Janez Miklavcic, Kareena Leanne Schnabl, Vera Christine Mazurak, Alan Bryan Robert Thomson, Michael Thomas Clandinin

“…Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling. Accelerated catabolism of ganglioside in intestinal disease results in increased proinflammatory signaling. …”
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The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB) by Vladimir F. Niculescu, Eugenia R. Niculescu

“…The cells lose their stemness and differentiation potential but persist in proliferation as low-grade polyploids (4n) through defective symmetric cell division (DSCD). Genomic integrity can be restored through homotypic cell and nuclear fusion, resulting in the formation of high-grade polyploids known as multinucleated genome repair syncytia, or by inductive hyperpolyploidization of more than 64n, as observed in single-celled polyploid giant cancer cells. …”
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The Possible Crystallization Process in the Origin of Bacteria, Archaea, Viruses, and Mobile Elements by Akari Yoshimura, Masayuki Seki

“…Bilayer lipid membrane formation, proto-cell formation with a permeable membrane, proto-cell division, and the evolution of membrane-associated biochemistry are presented in detail. …”
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The unconventional Xer recombination machinery of Streptococci/Lactococci. by Pascal Le Bourgeois, Marie Bugarel, Nathalie Campo, Marie-Line Daveran-Mingot, Jessica Labonté, Daniel Lanfranchi, Thomas Lautier, Carine Pagès, Paul Ritzenthaler

“…Homologous recombination between circular sister chromosomes during DNA replication in bacteria can generate chromosome dimers that must be resolved into monomers prior to cell division. In Escherichia coli, dimer resolution is achieved by site-specific recombination, Xer recombination, involving two paralogous tyrosine recombinases, XerC and XerD, and a 28-bp recombination site (dif) located at the junction of the two replication arms. …”
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Geometric model for dynamics of motor-driven centrosomal asters by Yuan-Nan Young, Vicente Gomez Herrera, Huan Zhang, Reza Farhadifar, Michael J. Shelley

“…Our findings both explain experimental observations, providing insights into the mechanisms governing spindle positioning and cell division dynamics, and show the possibility of new nonlinear phenomena in cell biology.…”
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Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases by Fayza A. Rahamtalla, Iman M. Shammat, Salma B. M. Mudawi, Maram Abbas, Mohammed A. H. Kheir Elsid, Mohammed S. M. Abdalla

“… Background: Telomeres, a protective sequence of DNA at the end of chromosomes, are essential for the maintenance of chromosomal integrity and stability. With each cell division, telomeres are shortened until a critical length is reached. …”
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Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation by Elizabeth M. Black, Carlos Andrés Ramírez Parrado, Isabelle Trier, Wenxue Li, Yoon Ki Joo, Jennifer Pichurin, Yansheng Liu, Lilian Kabeche

“…Abstract Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell cycle. …”
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Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. by You Ao, Qing Lan, Tianhua Yu, Zhichao Wang, Jing Zhang

“…Cellular senescence, a hallmark of aging marked by a permanent halt in cell division due to damage and stress, is crucial in aging and related diseases. …”
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CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance by Dijie Zheng, Yazhu Deng, Lu Deng, Zhiwei He, Xinghao Sun, Yanyu Gong, Binbin Shi, Deqin Lu, Chao Yu

“…Abstract Cell division cycle associated 7 (CDCA7) plays a role in various malignancies, especially pancreatic cancer (PC). …”
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Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length by Fan Zhang, De Cheng, Kenneth I. Porter, Emily A. Heck, Shuwen Wang, Hui Zhang, Christopher J. Davis, Gavin P. Robertson, Jiyue Zhu

“…Abstract Telomeres shorten with each cell division, serving as biomarkers of aging, with human tissues exhibiting short telomeres and restricted telomerase expression. …”
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Acute Putrescine Supplementation with Schwann Cell Implantation Improves Sensory and Serotonergic Axon Growth and Functional Recovery in Spinal Cord Injured Rats by J. Bryan Iorgulescu, Samik P. Patel, Jack Louro, Christian M. Andrade, Andre R. Sanchez, Damien D. Pearse

“…Polyamines are ubiquitous organic cations that play an important role in the regulation of the cell cycle, cell division, cytoskeletal organization, and cell differentiation. …”
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Traumatic Brain Injury Promotes Neurogenesis and Oligodendrogenesis in Subcortical Brain Regions of Mice by Olga Astakhova, Anna Ivanova, Ilia Komoltsev, Natalia Gulyaeva, Grigori Enikolopov, Alexander Lazutkin

“…Here, we investigated cell division and differentiation in non-neurogenic brain regions during the acute and delayed phases of TBI-induced neurodegeneration. …”
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Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells by Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Luca Matteo Todesca, Félix Alexandre Antunes Soares, Victor Shahin

“…Abstract Metastatic cancer cells undergo metabolic reprogramming, which involves changes in the metabolic fluxes, including endocytosis, nucleocytoplasmic transport, and mitochondrial metabolism, to satisfy their massive demands for energy, cell division, and proliferation compared to normal cells. …”
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Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy by Ryan Conesa-Bakkali, Macarena Morillo-Huesca, Jonathan Martínez-Fábregas

“…Under physiological conditions, lysosomal proteases, through non-canonical, extralysosomal activities, have been linked to cell differentiation, regulation of gene expression, and cell division. Under pathological conditions, these proteases have been linked to cancer, mostly through their extralysosomal activities in the cytosol and nuclei of cells. …”
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Phase separation of a microtubule plus-end tracking protein into a fluid fractal network by Mateusz P. Czub, Federico Uliana, Tarik Grubić, Celestino Padeste, Kathryn A. Rosowski, Charlotta Lorenz, Eric R. Dufresne, Andreas Menzel, Ioannis Vakonakis, Urs Gasser, Michel O. Steinmetz

“…Here, we have study the phase separation of Bik1, a CLIP-170 family member and key +TIP involved in budding yeast cell division. Bik1 is a dimer with a rod-shaped conformation primarily defined by its central coiled-coil domain. …”
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Cytomegalovirus Infection and Its Relationship with Leukocyte Telomere Length: A Cross-Sectional Study by Zhu Lin, Hongmei Gao, Bing Wang, Yongqiang Wang

“…Telomeres undergo shortening with each cell division, which could be accelerated by infection. …”
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Comparison of Real-Time Methods Demonstrating the Effects of Reduced Glutathione on Olfactory Neuroblasts by Alain Géloën, Emmanuelle Berger

“…This is the first evidence of a causal link between GSH and changes in cell volume and motility required for cell division, migration, and/or differentiation. Results show the importance of real-time analysis methods, without labelling, in the study of cell responses under culture conditions. …”
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