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Incomplete divisions between sister germline cells require Usp8 function
Published 2024-09-01“…Cytokinetic abscission is the final step of cell division, resulting in two separate daughter cells. …”
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62
Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia
Published 2025-01-01“…On one hand, it provides a source of building blocks for further cell division and serves as a method for removing damaged organelles, promoting cell survival. …”
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63
Reaction-Diffusion on a Spatial Mathematical Model of Cancer Immunotherapy with Effector Cells and IL-2 Compounds’ Interactions
Published 2021-01-01“…., p53 and pRb, from controlling the activation of the cell division and the cell apoptosis. In this paper, we consider the interactions among the cancer cell population, the effector cell population that is a part of the immune system, and cytokines that can be used to stimulate the effector cells called the IL-2 compounds. …”
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64
Artificial cell system as a tool for investigating pattern formation mechanisms of intracellular reaction-diffusion waves
Published 2024-11-01“…Intracellular positional information is crucial for the precise control of biological phenomena, including cell division, polarity, and motility. Intracellular reaction-diffusion (iRD) waves are responsible for regulating positional information within cells as morphogens in multicellular tissues. …”
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65
Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
Published 2025-02-01“…NMM exhibited a minimum inhibitory concentration (MIC) of 5 μM against S. aureus USA300, impacting cell division and the cell wall by repressing the expressions of genes in the division cell wall (dcw) gene cluster. …”
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66
Implications of noncoding RNAs for cancer therapy: Are we aiming at the right targets?
Published 2025-01-01“…It now appears that dual epigenetic regulatory systems exist in higher eukaryotic cells: a ncRNA network that governs essential cell functions, like cell fate decision and maintenance of homeostasis, and a protein-based system that presides over core physiological processes, like cell division and genomic maintenance. Modifications of the ncRNA network due to altered ncRNAs can cause the cell to shift towards to neoplastic phenotype; this is cancer initiation. …”
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67
Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA
Published 2025-01-01“…We recently discovered that Actinobacteria have a repurposed version of MoeA (Glp) linked to bacterial cell division. Since MoeA exists in all domains of life, our study explores how it gained multifunctionality over time. …”
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68
Carcinogenesis and Chemotherapy Viewed from the Perspective of Stoichiometric Network Analysis (SNA): What Can the Biological System of the Elements Contribute to an Understanding...
Published 2003-01-01“…The essential role of autocatalysis in biology and the drawbacks of either controlled or spontaneous cell division can be used to understand crucial aspects of carcinogenesis and chemotherapy because SNA describes and predicts effects of autocatalysis, including phase effects that may be due to some kind of intervention. …”
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69
Mitotic Kinases and p53 Signaling
Published 2012-01-01“…Deregulation of mitotic kinases is significantly associated with improper cell division and aneuploidy. Because of their importance during mitosis and the relevance to cancer, mitotic kinase signaling has been extensively studied over the past few decades and, as a result, several mitotic kinase inhibitors have been developed. …”
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70
A recurrent variant in PPP2R5C identified in individuals with macrocephaly, intellectual disability, and seizures
Published 2025-04-01“…This protein serine/threonine phosphatase is a component of multiple signaling pathways and is an established negative regulator of cell division, growth, and proliferation. De novo variants in other subunits of PP2A are associated with neurodevelopment disorders and intellectual disability (ID). …”
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71
Clinical isolates of Candida auris with enhanced adherence and biofilm formation due to genomic amplification of ALS4.
Published 2023-03-01“…A unique morphological feature of this fungus is its multicellular aggregating phenotype, which has been thought to be associated with defects in cell division. In this study, we report a new aggregating form of two clinical C. auris isolates with increased biofilm forming capacity due to enhanced adherence of adjacent cells and surfaces. …”
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72
<i>Helicobacter pylori</i> HP0135 Is a Small Lipoprotein That Has a Role in Outer Membrane Stability
Published 2025-01-01“…The phenotype of the Δ<i>hp0135</i> mutant suggests HP0135 has roles in stabilizing the cell envelope and cell division.…”
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73
The nonlinear cysteine redox dynamics in the i-space: A proteoform-centric theory of redox regulation
Published 2025-04-01“…The post-translational redox regulation of protein function by cysteine oxidation controls diverse biological processes, from cell division to death. However, most current site-centric paradigms fail to capture the nonlinear and emergent nature of redox regulation in proteins with multiple cysteines. …”
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74
Deciphering metabolic differentiation during Bacillus subtilis sporulation
Published 2025-01-01“…Abstract The bacterium Bacillus subtilis undergoes asymmetric cell division during sporulation, producing a mother cell and a smaller forespore connected by the SpoIIQ-SpoIIIA (or Q-A) channel. …”
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75
The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
Published 2010-01-01“…Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. …”
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76
Origins and Evolution of WUSCHEL-Related Homeobox Protein Family in Plant Kingdom
Published 2014-01-01“…WOX members contain the conserved homeodomain essential for plant development by regulating cell division and differentiation. However, the evolutionary relationship of WOX members in plant kingdom remains to be elucidated. …”
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77
Telomere Biology: Key to unlocking the fountain of youth…A Systematic Review.
Published 2024-11-01“…Deterioration of physiological functions is typically associated with ageing process.This often manifests as various diseases which eventually creates a burden on health infrastructure.Telomere attrition is a phenomenon which involves shortening of telomeres with each cycle of cell division.The phenomenon of “Telomere Attrition” is a “Bi edged sword” as while being a protective shield for the genome on one hand, it also is the cause of many senility related degenerative disorders. …”
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78
Sirtuins, Bioageing, and Cancer
Published 2011-01-01“…Sirtuins are heavily implicated in cell cycle, cell division, transcription regulation, and metabolism, which places the various family members at critical junctures in cellular metabolism. …”
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Impact of trainability on telomere dynamics of pet dogs (Canis lupus familiaris): An explorative study in aging dogs.
Published 2025-01-01“…Telomeres, essential for maintaining genomic integrity, undergo shortening with each cell division, leading to cellular senescence. Previous studies in humans have linked cognitive and social factors with telomere dynamics but in animals, such associations remain understudied. …”
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80
Spatio-temporal models of synthetic genetic oscillators
Published 2017-01-01“…Signal transduction pathways play a major role in many important aspects of cellular function e.g. cell division, apoptosis. One important class of signal transduction pathways is gene regulatory networks (GRNs). …”
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