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  1. 1
    Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

    Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design by Kim-Marie A. Dam, Harry B. Gristick, Yancheng E. Li, Zhi Yang, Priyanthi N.P. Gnanapragasam, Anthony P. West, Jr., Michael S. Seaman, Pamela J. Bjorkman

    Published 2025-05-01
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  2. 2
    Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression

    Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression by Siyu Chen, Yupeng Tang, Chunyu Zhang, You Li, Dongsheng Jia, Taiyun Wei

    Published 2025-08-01
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  3. 3
    How repeats rearrange chromosomes: The molecular basis of chromosomal inversions in deer mice

    How repeats rearrange chromosomes: The molecular basis of chromosomal inversions in deer mice by Landen Gozashti, Olivia S. Harringmeyer, Hopi E. Hoekstra

    Published 2025-05-01
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  4. 4
    The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

    The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy by Yu Fu, Xiaoyan Kang, Wenting Li, Zanhong Wang, Wanwan Luo, Bin Yang, Yaoyuan Cui, Funian Lu, Tianyu Qin, Xingyuan Hu, Jingjing Yin, Xi Li, Junpeng Fan, Beibei Wang, Gang Chen, Rourou Xiao, Zhiqiang Han, Ensong Guo, Xu Qin

    Published 2025-05-01
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  5. 5
    Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a

    Dual-nuclease single-cell lineage tracing by Cas9 and Cas12a by Cheng Chen, Yuanxin Liao, Miao Zhu, Li Wang, Xinran Yu, Meishi Li, Guangdun Peng

    Published 2025-01-01
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  6. 6
    A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency

    A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency by Berenice Cabrera-Martinez, Josselyn E. Garcia-Perez, Ryan M. Baxter, Victor G. Lui, Tusharkanti Ghosh, Ahmet Eken, Zander Kostka-Newman, John Rhey Mhar Garcia, Jeremy Rahkola, Rachel L. Gessner, Cullen M. Dutmer, Jared Klarquist, Eric M. Pietras, Debashis Ghosh, Sara A. Johnson, Ross M. Kedl, Elena W.Y. Hsieh

    Published 2025-07-01
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  7. 7
    Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance

    Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance by Henna Lehtonen, Heli Jokela, Julian Hofmann, Lauriina Tola, Arfa Mehmood, Florent Ginhoux, Burkhard Becher, Melanie Greter, Gennady G. Yegutkin, Marko Salmi, Heidi Gerke, Pia Rantakari

    Published 2025-02-01
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  8. 8
    Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression

    Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression by Maren Köhne, Mehrnoush Hadaddzadeh Shakiba, Lisa Schmidleithner, Jonas Schulte-Schrepping, Rebekka Scholz, Tarek Elmzzahi, Daniel Sommer, Yuanfang Li, Caterina Carraro, Elena De Domenico, Jannis Wißfeld, Kristian Händler, Doaa Hamada, Aleksej Frolov, Xiaoxiao Cheng, Ann-Kathrin Baumgart, Lisa Holsten, Collins Osei-Sarpong, Svenja Bourry, Yasser Thabet, Hannes Renken, Stefan Paulusch, Timothy Sadlon, Thorsten Buch, F. Thomas Wunderlich, Claudia Wickenhauser, Judith Alferink, Tanja Kuhlmann, Matthias Geyer, Lorenzo Bonaguro, Simon C. Barry, Joachim L. Schultze, Marc D. Beyer

    Published 2025-07-01
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  9. 9
    Regulation of the non-selective Na+ importer capacity of NRT1.2/NPF4.6/AIT1 by SOS2-mediated phosphorylation in Arabidopsis

    Regulation of the non-selective Na+ importer capacity of NRT1.2/NPF4.6/AIT1 by SOS2-mediated phosphorylation in Arabidopsis by Xiaoxiao Liu, Lei Zhang, Zeqi Zhao, Yue Zheng, Yue Ren, Xiaomin Zhao, Shizhong Zhang, Guodong Yang, Jinguang Huang, Kang Yan, Chunlong Li, Chengchao Zheng, Changai Wu

    Published 2025-06-01
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  10. 10
    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint

    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint by Juliana N. Flaherty, Enakshi Sivasudhan, Matthew Tegowski, Zheng Xing, Madeline M. McGinnis, Olga V. Hunter, Kyah M. Featherston, Komal Sethia, Benjamin P. Tu, Kate D. Meyer, Nicholas K. Conrad

    Published 2025-07-01
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  11. 11
    GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation

    GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation by Yatao Chen, Yajie Wan, Xiaoying Pei, Ziqi Wei, Tan Wang, Jun Zhang, Liming Chen

    Published 2025-05-01
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  12. 12
    scCamAge: A context-aware prediction engine for cellular age, aging-associated bioactivities, and morphometrics

    scCamAge: A context-aware prediction engine for cellular age, aging-associated bioactivities, and morphometrics by Vishakha Gautam, Subhadeep Duari, Saveena Solanki, Mudit Gupta, Aayushi Mittal, Sakshi Arora, Anmol Aggarwal, Anmol Kumar Sharma, Sarthak Tyagi, Rathod Kunal Pankajbhai, Arushi Sharma, Sonam Chauhan, Shiva Satija, Suvendu Kumar, Sanjay Kumar Mohanty, Juhi Tayal, Nilesh Kumar Dixit, Debarka Sengupta, Anurag Mehta, Gaurav Ahuja

    Published 2025-02-01
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  13. 13
    The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery

    The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery by Tyler M. Maclay, Jenna M. Whalen, Matthew J. Johnson, Catherine H. Freudenreich

    Published 2025-08-01
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  14. 14
    DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition

    DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition by Madeline N. Hayes, Sarah Cohen-Gogo, Lynn Kee, Xueting Xiong, Alex Weiss, Mehdi Layeghifard, Yagnesh Ladumor, Ivette Valencia-Sama, Anisha Rajaselvam, David R. Kaplan, Anita Villani, Adam Shlien, Daniel A. Morgenstern, Meredith S. Irwin

    Published 2025-04-01
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  15. 15
    High-content image-based pooled screens reveal regulators of synaptogenesis

    High-content image-based pooled screens reveal regulators of synaptogenesis by Anna Le, Thomas Biederer, Paul C. Blainey

    Published 2025-07-01
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  16. 16
    Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans

    Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans by Jie Zhang, Jing Xia, Huihui Zhou, Shuo Wang

    Published 2025-07-01
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  17. 17
    Transcriptional profile of the rat cardiovascular system at single-cell resolution

    Transcriptional profile of the rat cardiovascular system at single-cell resolution by Alessandro Arduini, Stephen J. Fleming, Ling Xiao, Amelia W. Hall, Amer-Denis Akkad, Mark D. Chaffin, Kayla J. Bendinelli, Nathan R. Tucker, Irinna Papangeli, Helene Mantineo, Patricio Flores-Bringas, Mehrtash Babadi, Christian M. Stegmann, Guillermo García-Cardeña, Mark E. Lindsay, Carla Klattenhoff, Patrick T. Ellinor

    Published 2025-01-01
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  18. 18
    MetA is a ‘‘thermal fuse’’ that inhibits growth and protects Escherichia coli at elevated temperatures

    MetA is a ‘‘thermal fuse’’ that inhibits growth and protects Escherichia coli at elevated temperatures by Severin J. Schink, Zara Gough, Elena Biselli, Mariel Garcia Huiman, Yu-Fang Chang, Markus Basan, Ulrich Gerland

    Published 2025-01-01
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  19. 19
    A cholinergic spinal pathway for the adaptive control of breathing

    A cholinergic spinal pathway for the adaptive control of breathing by Minshan Lin, Giulia Benedetta Calabrese, Anthony V. Incognito, Matthew T. Moore, Aambar Agarwal, Richard J.A. Wilson, Laskaro Zagoraiou, Simon A. Sharples, Gareth B. Miles, Polyxeni Philippidou

    Published 2025-08-01
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  20. 20
    SPT6 regulates H3K14Ac deposition in mouse embryonic stem cells

    SPT6 regulates H3K14Ac deposition in mouse embryonic stem cells by Daixuan Zhang, Li Dong, Ying Cai, Peng Zhao, Qingqing Cai, Jian Zhang, Yajun Hu, Mandi Mu, Siyi Cheng, Jin Wang, Min Zeng, Chenxi He, Lei Zhang, Hui Yang, Fei Xavier Chen, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Hongjie Shen

    Published 2025-06-01
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