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  1. 81
    Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

    Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis by Kylie R. VanDerMolen, Martin A. Newman, Peter C. Breen, Yunjing Gao, Laura A. Huff, Robert H. Dowen

    Published 2025-01-01
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  2. 82
    Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection

    Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection by Ning Zhou, Jingchen Yu, Xujiao Liu, Chengxi Li, Huang Tang, Lin Lyu, Chengwei Wu, Yana Chen, Jian Zhang, Jinjing Ni, Danni Wang, Jing Tao, Wenjuan Wu, Yu Zhang, Yun Feng, Yanjie Chao, Jie Lu, Ping He, Yu-Feng Yao

    Published 2025-01-01
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  3. 83
    C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity

    C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity by Diksha Agnihotri, Chi-Chang Lee, Po-Chao Lu, Ruei-Yu He, Yung-An Huang, Hung-Chih Kuo, Joseph Jen-Tse Huang

    Published 2025-01-01
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  4. 84
    G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis

    G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis by Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan

    Published 2025-01-01
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  5. 85
    Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors

    Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors by Ashley F. George, Jason Neidleman, Xiaoyu Luo, Julie Frouard, Natalie Elphick, Kailin Yin, Kyrlia C. Young, Tongcui Ma, Alicer K. Andrew, Ifeanyi J. Ezeonwumelu, Jesper G. Pedersen, Antoine Chaillon, Magali Porrachia, Brendon Woodworth, Martin R. Jakobsen, Reuben Thomas, Davey M. Smith, Sara Gianella, Nadia R. Roan

    Published 2025-01-01
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  6. 86
    Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer

    Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer by Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Sachin Mishra, Anchala Pandey, Dimple Notani, Sanjeev Shukla

    Published 2025-02-01
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  7. 87
    Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells

    Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells by Simon N. Chu, Eric Soupene, Devesh Sharma, Roshani Sinha, Travis McCreary, Britney Hernandez, Huifeng Shen, Beeke Wienert, Chance Bowman, Han Yin, Benjamin J. Lesch, Kun Jia, Kathleen A. Romero, Zachary Kostamo, Yankai Zhang, Tammy Tran, Marco Cordero, Shota Homma, Jessica P. Hampton, James M. Gardner, Bruce R. Conklin, Tippi C. MacKenzie, Vivien A. Sheehan, Matthew H. Porteus, M. Kyle Cromer

    Published 2025-01-01
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  8. 88
    Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia

    Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia by Zeng Zhang, Quan Guo, Zhihan Yang, Yukai Sun, Shuaiming Jiang, Yangli He, Jiahe Li, Jiachao Zhang

    Published 2025-02-01
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  9. 89
    Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping

    Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping by Young Hye Kwon, Joseph J. Salvo, Nathan L. Anderson, Donnisa Edmonds, Ania M. Holubecki, Maya Lakshman, Kwangsun Yoo, B.T. Thomas Yeo, Kendrick Kay, Caterina Gratton, Rodrigo M. Braga

    Published 2025-01-01
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  10. 90
    G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration

    G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration by Liana C. Boraas, Mengwei Hu, Pieter Martino, Lauren Thornton, Charles E. Vejnar, Gang Zhen, Longhui Zeng, Dylan M. Parker, Andy L. Cox, Antonio J. Giraldez, Xiaolei Su, Christine Mayr, Siyuan Wang, Stefania Nicoli

    Published 2025-02-01
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  11. 91
    The OsEBF1-OsEIL5-OsPP91 module regulates rice heat tolerance via ubiquitination and transcriptional activation

    The OsEBF1-OsEIL5-OsPP91 module regulates rice heat tolerance via ubiquitination and transcriptional activation by Jianping Liu, Ke Wang, Guining Wang, Zhi Peng, Tao Wang, Yang Meng, Jinli Huang, Jiaohan Huo, Xin Li, Xiaoqi Zhu, Feiyun Xu, Qian Zhang, Zhengrui Wang, Hao Chen, Ya Wang, Weifeng Xu

    Published 2025-02-01
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  12. 92
    The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability

    The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability by Emily Graham, Lucia Rampazzo, Chin Wei Brian Leung, Jacob Wall, Emőke Zsanett Gerőcz, Mikhail Liskovykh, Nikolay Goncharov, Xanita Saayman, Ramazan Gundogdu, Masato T. Kanemaki, Hiroshi Masumoto, Vladimir Larionov, Natalay Kouprina, Fumiko Esashi

    Published 2025-02-01
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  13. 93
    Redox proteomics reveal a role for peroxiredoxinylation in stress protection

    Redox proteomics reveal a role for peroxiredoxinylation in stress protection by Gerhard Seisenbacher, Zrinka Raguz Nakic, Eva Borràs, Eduard Sabidó, Uwe Sauer, Eulalia de Nadal, Francesc Posas

    Published 2025-02-01
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  14. 94
    Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer

    Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer by Ge Li, Zhenke Wen, Sidong Xiong

    Published 2025-01-01
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  15. 95
    Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM

    Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM by Matthew Cook, Christian Freniere, Chunxiang Wu, Faith Lozano, Yong Xiong

    Published 2025-02-01
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  16. 96
    Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy

    Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy by Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang

    Published 2025-02-01
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  17. 97
    Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

    Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

    Published 2025-02-01
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  18. 98
    A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells

    A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells by Rachel McCole, James Nolan, David M. Reck, Craig Monger, Samantha Rustichelli, Eric Conway, Gerard L. Brien, Cheng Wang, Orla Deevy, Hannah K. Neikes, Frances M. Bashore, Aoibhinn Mooney, Richard Flavin, Elisabeth Vandenberghe, Sarena F. Flanigan, Diego Pasini, Chen Davidovich, Michiel Vermeulen, Lindsey I. James, Evan Healy, Adrian P. Bracken

    Published 2025-01-01
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  19. 99
    Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A

    Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A by Chen Shen, Wenhui Lu, Siva B. Merugu, Aradhana Bharti, Said M. Afify, Lauren Schnitkey, Daniel T. Wynn, Fan Yang, Thomas M. Rohwetter, Anmada Nayak, Nawat Bunnag, Carolina Cywiak, Hsin-Yao Tang, Brent T. Harris, Christopher Albanese, Chukwuemeka Ihemelandu, Melanie H. Cobb, Arminja Kettenbach, Ethan Lee, Yashi Ahmed, David J. Robbins

    Published 2025-02-01
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  20. 100
    Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice

    Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice by Fabiola Silva Angulo, Claudine Vanessa Joseph, Lou Delval, Lucie Deruyter, Séverine Heumel, Marie Bicharel, Patricia Brito Rodrigues, Valentin Sencio, Tom Bourguignon, Marina Gomes Machado, Marie Fourcot, Stéphane Delhaye, Sophie Salomé-Desnoulez, Philippe Valet, Serge Adnot, Isabelle Wolowczuk, Jean-Claude Sirard, Muriel Pichavant, Bart Staels, Joel T. Haas, Ruxandra Gref, Jimmy Vandel, Arnaud Machelart, Hélène Duez, Benoit Pourcet, François Trottein

    Published 2025-02-01
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