Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…The hypothesis suggests that these advanced scaffolds can achieve controlled Insulin release, enhancing cartilage regeneration. This research aims to develop to yield mechanically optimized, bioactive 3D-printed scaffolds for regulated delivery of Insulin to promote cartilage regeneration.…”
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The Potential of Menstrual Blood-Derived Mesenchymal Stem Cells for Cartilage Repair and Regeneration: Novel Aspects by I. Uzieliene, G. Urbonaite, Z. Tachtamisevaite, A. Mobasheri, E. Bernotiene

“…MSCs seem promising candidates for cartilage regeneration; however, no clinically effective stem cell-based repair method has yet emerged. …”
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Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 by Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao

“…Results Betain-treated SCAPs demonstrated stronger cartilage regeneration in vitro and promoted cartilage repair of TMJOA in vivo. …”
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Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage by Chunsheng Liu, Le Zhao, Hao Dong, Zekun Hua, Yanqin Wang, Yongxing Wang, Pengcui Li, Xiaochun Wei, Kai Zhang, Yanru Xue, Xiaogang Wu, Weiyi Chen

“…This may provide valuable insights for further investigation into the microscopic mechanisms of cell proliferation, differentiation, and cartilage regeneration induced by electrical stimulation.…”
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A thermo-responsive chitosan-based injectable hydrogel for delivery of curcumin-loaded polycaprolactone microspheres to articular cartilage: in-vitro and in-vivo assessments by Farnoosh Kalantarnia, Sasan Maleki, Amir Shamloo, Kazem Akbarnataj, Sayed Navid Tavoosi

“…In-vivo evaluations on rabbit models indicated significant cartilage regeneration, evidenced by improved locomotion behavior and accelerated cartilage formation with minimized defect boundaries. …”
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Synergistic Effects of FGF-18 and TGF-β3 on the Chondrogenesis of Human Adipose-Derived Mesenchymal Stem Cells in the Pellet Culture by Liangjie Huang, Lingxian Yi, Chunli Zhang, Ying He, Liangliang Zhou, Yan Liu, Long Qian, Shuxun Hou, Tujun Weng

“…Our results provide critical information on the therapeutic use of ADSCs with the help of FGF-18 and TGF-β3 for cartilage regeneration.…”
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Magnetic Targeted Delivery of Induced Pluripotent Stem Cells Promotes Articular Cartilage Repair by Shinji Kotaka, Shigeyuki Wakitani, Akira Shimamoto, Naosuke Kamei, Mikiya Sawa, Nobuo Adachi, Mituo Ochi

“…Cartilage regeneration treatments using stem cells are associated with problems due to the cell source and the difficulty of delivering the cells to the cartilage defect. …”
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Efficacy and Safety of a Stimulator Using Low-Intensity Pulsed Ultrasound Combined with Transcutaneous Electrical Nerve Stimulation in Patients with Painful Knee Osteoarthritis by Eu-Deum Kim, Yu Hui Won, Sung-Hee Park, Jeon-Hwan Seo, Da-Sol Kim, Myoung-Hwan Ko, Gi-Wook Kim

“…We evaluated the effectiveness of this therapy against pain, physical function, and cartilage regeneration. Moreover, we aim to prove the superiority of the effects of LIPUS combined with TENS therapy compared with only TENS therapy. …”
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Comparison between Intra-Articular Injection of Infrapatellar Fat Pad (IPFP) Cell Concentrates and IPFP-Mesenchymal Stem Cells (MSCs) for Cartilage Defect Repair of the Knee Joint... by Yaguang Han, Haobo Li, Rong Zhou, Jun Wu, Ziye Liu, Huan Wang, Jiahua Shao, Yi Chen, Jun Zhu, Qiwei Fu, Qirong Qian, Yiqin Zhou

“…In comparison to the latter, the groups treated with IPFP-MSCs and IPFP cell concentrates showed considerably better cartilage regeneration. Overall, IPFP-MSCs represent an effective therapeutic strategy for stimulating articular cartilage regeneration. …”
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Mesenchymal Stem Cells in Oriented PLGA/ACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model by Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo

“…Hence, articular cartilage regeneration remains a major challenge in orthopedics. …”
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Spidroin-Based Biomaterials in Tissue Engineering: General Approaches and Potential Stem Cell Therapies by Qi Zhang, Min Li, Wenbo Hu, Xin Wang, Jinlian Hu

“…., lung tissue engineering, vascularization, bone and cartilage regeneration, and peripheral nerve repair), and finally, we prospected the development direction and manufacturing technology of building more refined and customized spidroin-based protein scaffolds.…”
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Insight in Hypoxia-Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine by Agata Nowak-Stępniowska, Paulina Natalia Osuchowska, Henryk Fiedorowicz, Elżbieta Anna Trafny

“…These agents are not studied so wildly as hypoxia but, considering the low cost and ease of use, are believed to find application as pretreatment of many diseases such as ischemic heart disease and myocardial fibrosis and promote cardiac and cartilage regeneration. The knowledge of MSC priming is critical in evaluating safety procedures and use in clinics. …”
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Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis by Baldur Kristjánsson, Sittisak Honsawek

“…In this review the history and early uses of MSCs in cartilage regeneration are reviewed and different approaches in current trends are explained and evaluated.…”
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Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy by Ronaldo J. F. C. do Amaral, Henrique V. Almeida, Daniel J. Kelly, Fergal J. O’Brien, Cathal J. Kearney

“…There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. …”
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Comparison of intra articular autologous platelet-rich plasma with steroids in osteoarthritis knee: Experience from a North Indian tertiary care center by M N Arjun, Vivek Vasdev, Kunal Kishore, Arun Hegde, Krishnan Shanmuganandan, Abhishek Kumar, Uday Bhanu Kovilapu, Roopa Shivashankar

“…It accelerates the process of healing, ligament repair, cartilage regeneration, and bone formation when given in supraphysiological doses. …”
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Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan by Jun Yamada, Kunikazu Tsuji, Kazumasa Miyatake, Yu Matsukura, Kahaer Abula, Makiko Inoue, Ichiro Sekiya, Takeshi Muneta

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Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects by Long Chen, Lang Li, Fei Xing, Jing Peng, Kun Peng, Yuanzheng Wang, Zhou Xiang

“…Twelve weeks after the injection, the histologic analyses (HE, toluidine blue, and Masson trichrome staining), immunohistochemistry (aggrecan and collagen II), and histologic grade of the sample indicated that hUSCs-HA could stimulate much more neocartilage formation compared with hUSCs alone, pure HA, and saline, which only induced the modest cartilage regeneration. In this study, we demonstrated that hUSCs could be a potential cell source for stem cell therapies to treat cartilage-related defects in the future.…”
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Autologous Bone Marrow-Derived Chondrocytes for Patients with Knee Osteoarthritis: A Randomized Controlled Trial by Mir Sadat-Ali, Abdallah S. AlOmran, Sulaiman A. AlMousa, Hasan N. AlSayed, Khalid W. AlTabash, Mohammed Q. Azam, Tarek M. Hegazi, Sadananda Acharya

“…To assess the cartilage regeneration of the damaged cartilage, magnetic resonance imaging (MRI) was used. …”
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The Effect of Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Cartilage Repair in Rabbits by Hongwei Yang, Meng Cong, Weixiao Huang, Jin Chen, Min Zhang, Xiaosong Gu, Cheng Sun, Huilin Yang

“…In rabbits with articular cartilage defects, local administration with hBMSC-EXOs facilitates cartilage regeneration as evidenced by gross view and hematoxylin-eosin (H&E) and Saf-O/Fast Green staining. …”
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Production of Adult Human Synovial Fluid-Derived Mesenchymal Stem Cells in Stirred-Suspension Culture by Kristen D. Jorgenson, David A. Hart, Roman Krawetz, Arindom Sen

“…The chondrogenic potential of synovial fluid-derived mesenchymal stem cells (SF-MSCs) supports their use in cartilage regeneration strategies. However, their paucity in synovial fluid necessitates their proliferation in culture to generate clinically relevant quantities. …”
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