Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…The first of these studies aims to assess whether a pre-emptive statin therapy genotyping scheme reduces the incidence of statin-associated muscle symptoms (SAMS) in a population at risk of cardiovascular disease susceptible of receiving high-intensity or moderate-intensity doses of statins: The PREVESTATGx trial.Methods and analysis the PREVESTATGX trial is a multicentre, adaptive randomised controlled pragmatic phase IV clinical trial nested to the iPHARMGx master protocol with two parallel arms, aiming for superiority. …”
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Long-term outcomes after AKI in hospitalized patients with COVID-19 by Bernardo Marques da Silva, Joana Gameiro, Joana Lei Teixeira, Cláudia Costa, Carolina Branco, João Oliveira, João Bernardo, Filipe Marques, José Agapito Fonseca, José António Lopes

“…On a multivariate analysis, older age (adjusted HR 1.02 (95% CI: 1.01–1.04), p = 0.008), cardiovascular disease (adjusted HR 2.22 (95% CI: 1.24–3.95), p = 0.007), chronic kidney disease (adjusted HR 5.15 (95% CI: 2.22–11.93), p < 0.001), and AKI (adjusted HR 1.76 (95% CI: 1.12–2.78), p = 0.015) were independent predictors of MAKE. …”
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Effect of a Mediterranean Diet Intervention on Dietary Glycemic Load and Dietary Glycemic Index: The PREDIMED Study by Ana Isabel Rodríguez-Rejón, Itandehui Castro-Quezada, Cristina Ruano-Rodríguez, María Dolores Ruiz-López, Almudena Sánchez-Villegas, Estefanía Toledo, Reyes Artacho, Ramón Estruch, Jordi Salas-Salvadó, María Isabel Covas, Dolores Corella, Enrique Gómez-Gracia, José Lapetra, Xavier Pintó, Fernando Arós, Miquel Fiol, Rosa María Lamuela-Raventós, Valentina Ruiz-Gutierrez, Helmut Schröder, Emilio Ros, Miguel Ángel Martínez-González, Lluis Serra-Majem

“…Participants were older subjects at high risk for cardiovascular disease. This analysis included 2866 nondiabetic subjects. …”
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Long-term trends in the prevalence of cardiovascular-kidney-metabolic syndrome in South Korea, 2011–2021: a representative longitudinal serial studyResearch in context by Yesol Yim, Jae E. Lee, Yejun Son, Soeun Kim, Hojae Lee, Sooji Lee, Wonwoo Jang, Hanseul Cho, Hayeon Lee, Kyeongmin Lee, Hyesu Jo, Jaeyu Park, Jiyeon Oh, Louis Jacob, Jiseung Kang, Hyunji Sang, Sang Youl Rhee, Dong Keon Yon

“…Summary: Background: The American Heart Association recently introduced a new framework, known as cardiovascular-kidney-metabolic (CKM) syndrome, aimed at the early prevention of cardiovascular disease. However, this syndrome has not been studied extensively outside of the United States. …”
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Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality by Patricia de Sequera, Javier Arias, Borja Quiroga, María Benavent, Fabio Procaccini, Iago Romero, Guillermo López, Javier Diez, Alberto Ortiz

“…Introduction: Chronic kidney disease (CKD) is associated with high cardiovascular disease (CVD) risk, and requires specific interventions to decreases CVD risk.The guidelines indicate that systematic global CVD risk assessment is recommended in individuals with any major vascular risk factor. …”
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Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“… Introduction Impaired glycaemic control is a major risk factor for cardiovascular disease, the leading cause of death worldwide (Roth et al., 2020). …”
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Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality by Patricia de Sequera, Javier Arias, Borja Quiroga, María Benavent, Fabio Procaccini, Iago Romero, Guillermo López, Javier Diez, Alberto Ortiz

“…Introduction: Chronic kidney disease (CKD) is associated with high cardiovascular disease (CVD) risk, and requires specific interventions to decreases CVD risk.The guidelines indicate that systematic global CVD risk assessment is recommended in individuals with any major vascular risk factor. …”
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Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design by Hiroshi Matsumoto, Akihiro Nomura, Hayato Tada, Hirofumi Okada, Atsushi Nohara, Masa-aki Kawashiri, Koji Maeno, Manabu Fujimoto, Shohei Yoshida, Masaya Shimojima, Toyonobu Tsuda, Mika Mori, Shin-ichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Noboru Fujino, Akihiro Inazu, Shizuko Takahara, Yasuhito Imai, Takao Matsubara, Kenji Miwa, Masanobu Namura, Hidenobu Terai, Taiji Yoshida, Tsutomu Araki, Masahiro Minamoto, Toru Aburao, Yuji Ito, Chiaki Nakanishi, Suguru Kawasaki, Yasuhiro Todo, Junji Koizumi, Yoshihito Kita, Hiroaki Shintaku, Akihiko Hodatsu, Hidekazu Ino, Toshinori Higashikata, Mutsuko Takata, Katsushi Misawa, Masato Yamaguchi, Yoshihiro Noji, Kazuo Osato, Tomohito Mabuchi, Taro Ichise, Bunji Kaku, Shoji Katsuda, Katsuharu Uchiyama, Kensuke Fujioka, Takuya Nakahashi, Tsuyoshi Nozue, Ichiro Michishita, Kazuo Usuda, Kanichi Otowa, Kazuyasu Okeie, Satoshi Hirota, Isao Aburadani, Keisuke Kurokawa, Osamu Takatori, Shunichiro Hondo, Hiroyuki Oda, Shigeo Takata, Hisayoshi Murai, Masaki Kinoshita, Hideo Nagai, Yoshiteru Sekiguchi, Satoru Sakagami, Wataru Omi, Chikara Fujita, Tatsuo Katsuki, Hiroshi Ootsuji, Atsushi Igarashi, Manabu Nakano, Seiichiro Okura, Yasuhito Mitamura, Naoki Sugimoto, Masakazu Yamamoto, Hironobu Akao, Kouji Kajinami, Masayuki Takamura

“…The primary endpoint of this study is new atherosclerotic cardiovascular disease (ASCVD) events. The secondary endpoints are as follows: LDL cholesterol, secondary ASCVD events and the occurrence of other diseases including hypertension, diabetes and malignancies.Ethics and dissemination This study is being conducted in compliance with the Declaration of Helsinki, the Ethical Guidelines for Medical and Health Research Involving Human Subjects, and all other applicable laws and guidelines in Japan. …”
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Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional studyResearch in context by Weiping Jia, Rong Yu, Limin Wang, Dalong Zhu, Lixin Guo, Jianping Weng, Hong Li, Mei Zhang, Xiaoqi Ye, Zhiguang Zhou, Dajin Zou, Qiuhe Ji, Xiaohui Guo, Yinan Zhang, Dong Lang, Jiarui Wu, Jing Wu, Xuhong Hou, Xiaohui Guo, Kai Wu, Liming Chen, Demin Liu, Guangyao Song, Linyi Shu, Jing Yang, Yan Wang, Dongmei Li, Qiansha Guo, Ling Li, Na Wu, Yadong Sun, Huifang Cheng, Hongyu Kuang, Huijuan Zhang, Weiping Jia, Xuhong Hou, Dalong Zhu, Jian Zhu, Hong Li, Fenping Zheng, Qiu Zhang, Honglin Hu, Gang Chen, Xingquan Yang, Xiaoyang Lai, Jianping Liu, Li Chen, Ming Dong, Zhigang Zhao, Jian Liu, Guangda Xiang, Junxia Zhang, Zhiguang Zhou, Jian Peng, Jianping Weng, Longyi Zeng, Yuzhen Liang, Guoqiao Li, Kaining Chen, Leweihua Lin, Qifu Li, Qingfeng Cheng, Xingwu Ran, Dawei Chen, Hong Li, Xin Nian, Lihui Yang, Shuyou Meng, Jing Xu, Junhong Long, Jing Liu, Qi Zhang, Qingxiang Dai, Xiaomin Xie, Guirong Bai, Jun Li, Tao Li, Zhong Dong, Tao Zhang, Sijia Liu, Yong Yang, Kun Geng, Wenlong Zheng, Zhihong Li, Hui Wang, Zuojun Wu, Miao Wang, Jixin Sun, Jianwei Zhou, Jun An, Huaqing Shen, Yanfang Li, Zeping Ren, Xiuli Xue, Shaohui Jia, Yongping Zheng, Jiaoxia Li, Yonggang Qian, Ping Ma, Yan Su, Liang Cao, Xuyi Yang, Guowei Pan, Guangzhi Pan, Ling Jin, Quanfu Yu, Yunfei Liu, Yingli Zhu, Zhifang Cheng, Jun Yang, Chundi Jia, Qing Wang, Shichun Yan, Jingyang Huang, Yumei Chi, Li Zhang, Ruifa Pang, Yan Shi, Yan Lu, Yiling Wu, Jie Yu, Chunxiang Wu, Jinyi Zhou, Yunxia Wu, Ning Zhang, Jing Sun, Xiumei Tian, Jieming Zhong, Jingying Chen, Kaixu Xie, Lingjuan Fu, Xiaohua Wang, Yeji Chen, Ling Zeng, Zhenqian Cao, Maomin Yang, Biao Hu, Wenling Zhong, Qingyan Liu, Zhiding Huang, Qingbin Lai, Yuyu Zhang, Liping Zhu, Yujing Zhao, Wuming Tao, Yonghai Tu, Lin Zhou, Xiaolei Guo, Benzheng Chai, Liping Ding, Yuewei Zou, Dongzhi Li, Li Hua, Shixian Feng, Jianli Guo, Wanguang Liu, Qingxiang Li, Yunzhi Zheng, Minli Xu, Lan Zhang, Chunbo Li, Yingchao Wan, Chi Hu, Shengping Xu, Biyun Chen, Huilin Liu, Xiaojia Bian, Wenwei Chen, Honghua Li, Yanjun Xu, Fan Weng, Hong Wu, Weijin Zhang, Liankai Zhu, Jun Meng, Jin Yang, Yongsong Zeng, Gaoke Zhai, Lingfeng Qin, Yi Lu, Zhenwang Fu, Shukuan Wu, Caigang Li, Na Wang, Lianfen Chen, Xianbin Ding, Qi Zhou, Yiling Xie, Rui Chen, Dongsheng Yang, Ying Deng, Youping Hu, Bo Huang, Ping Wang, Peng Cai, Changyan Peng, Xiaofang Chen, Ling Li, Liang Xiao, Chenglin Wang, Chaogang Tan, Daobin Chen, Min Chen, Mingfang Qin, Zhaomin Lei, Jianzhi Qiu, Wei Yu, Yunfei Li, Guoxia Bai, Ying Wang, Lin Qiu, Ning Wang, Xudong Zhao, Ani Yan, Jianfei Liu, Tingcai Wang, Kaihua Hao, Zaihong Zhang, Zhanqi Xian, Tenghuan Ma, Zhihua Xu, Yi Yang, Hongli Wang, Rong Li, Zhonggang Zhao, Caixia Fan, Purhati, Hongjun Xu, Liping Gao

“…Among those with CKD, 25.7% had diabetic retinopathy (DR) and 22.3% had cardiovascular disease (CVD). The weighted prevalence rates of albuminuria and decreased eGFR were consistently higher among southern residents, rural residents, and individuals with more severe DR and a history of CVD than their counterparts (all p < 0.05). …”
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Cardiac secreted HSP90α exacerbates pressure overload myocardial hypertrophy and heart failure by Le Pan, Chenxing Huang, Xuejuan Jin, Jian Wu, Kejia Jin, Jingyi Lin, Ying Wang, Jianxuan Li, Chao Yin, Xiang Wang, Lei Zhang, Guoping Zhang, Hangming Dong, Junli Guo, Issei Komuro, Yuxiang Dai, Yunzeng Zou, Hui Gong

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Preoperative D-dimer level predicts adverse events after coronary endarterectomy combined with coronary artery bypass grafting: a retrospective cohort study by Lianxin Chen, Xieraili Tiemuerniyazi, Ziang Yang, Liaoming He, Yifeng Nan, Yangwu Song, Wei Zhao, Wei Feng

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Gender-Related Differences in Clinical Characteristics and Outcomes of Premature Coronary Artery Disease: Insight from the FOCUS Registry by Ya’nan Qu, Ji’e Yang, Feng Zhang, Chenguang Li, Yuxiang Dai, Hongbo Yang, Yang Gao, Yueyi Pan, Kang Yao, Dong Huang, Hao Lu, Jianying Ma, Juying Qian, Junbo Ge

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Echocardiographic Assessment of Ebstein's Anomaly in a 60-Year-Old Man by Elisabetta Palmerini, Duccio Federici, Alessia Del Pasqua, Sonia Bernazzali, Matteo Lisi, Mario Chiavarelli, Sergio Mondillo

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Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment by Kai Zhang, Xiaoxia Liu, Siyu Huang, Xinrui Liu, Meiqi Zhao, Chao Xue, Shijun Xia, Jianzeng Dong, Yu Kong, Changsheng Ma

“…Abstract Background Cardiovascular diseases (CVDs) marked with cardiac morphological or hemodynamical abnormalities are associated with mild cognitive impairment (MCI). …”
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Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles by Hanjing Li, Yining Liu, Yuqing Lin, Sijia Li, Chenlu Liu, Ao Cai, Wei Li, Wanyu Zhang, Xinlu Gao, Zhongyu Ren, Haoyu Ji, Yang Yu, Xiuxiu Wang, Wenya Ma, Ning Wang, Dan Zhao, Tianlong Li, Yu Liu, Benzhi Cai

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Editorial: Immunity and pulmonary vascular diseases: challenges, advances and future perspectives by Qi Jin, Qi Jin, Daxin Zhou, Daxin Zhou, Zhihong Liu, Djuro Kosanovic

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Low-Dose Gallic Acid Administration Does Not Improve Diet-Induced Metabolic Disorders and Atherosclerosis in Apoe Knockout Mice by Jie Bai, Qiu-Yue Lin, Xiangbo An, Shuang Liu, Yao Wang, Yunpeng Xie, Jiawei Liao

“…Whether GA could be beneficial for atherosclerotic cardiovascular diseases therefore needs further exploration.…”
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Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway by Tang Nannan, Li Jiatong, Wang Zhuo, Zuo Jinlu, Zhang Zifeng, Huang Di, Han Yannan, Chen Yuqing, Sun Yilin, Li Xiang, Mu Ruxue, Ma Qingxue, Zhang Jie, Wu Jiaying, Wang He, Zhao Hongxia, Dong Xingli, Wang Zhiguo, Liu Yu, Zhao Dan, Yang Baofeng

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Differential Diagnosis, Clinical Characteristics, and Interventions of Braid-Like Coronary Artery: Case Series Analysis Based on Optical Coherence Tomography by Wen-Xiu Leng, Huan-Huan Wang, Hai Ming Liu, Ying Song, Lian-Jun Xu, Jing-Jing Xu, Xue-Yan Zhao, Xiao-Yan Tan, Rong Li, Zhan Gao, Li-Jian Gao, Jue Chen, Jin-Qing Yuan, Yue-Jin Yang, Ji-Lin Chen

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Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention by Runzhen Chen, Chen Liu, Peng Zhou, Yu Tan, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Yi Chen, Li Song, Hanjun Zhao, Hongbing Yan

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