Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study by Simon Thom, Alice Stanton, Jamil Mayet, Amit Kaura, Darrel Francis, Anoop SV Shah, Andrew Sharp, Alun D Hughes, Neil R Poulter, Anenta Ratneswaren, Tong Wu, Somayeh Rostamian, Devan Wasan, PS Sever

“…Unadjusted and adjusted Cox regression survival models were constructed to investigate the association between tissue Doppler echocardiography measurements and long-term cardiovascular mortality.Results Among 506 hypertensive patients (median age 64, interquartile range (58, 69), 87% male), there were 200 (40%) deaths over a 20-year follow-up period. 60 deaths (12%) were cardiovascular-related.A reduction in e′ was independently associated with increased cardiovascular mortality, after adjusting for the ACC/AHA Atherosclerotic Cardiovascular Disease (ASCVD) risk score, with an inverse HR of 1.22 per 1 cm/s decrease (95% CI 1.04–1.43). …”
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Associations of Tea Consumption With the Risk of All‐Cause and Cause‐Specific Mortality Among Adults With Type 2 Diabetes: A Prospective Cohort Study in China by Lifeng Wang, Xikang Fan, Jian Su, Yu Qin, Zhongming Sun, Yan Lu, Shujun Gu, Chong Shen, Jinyi Zhou, Hao Yu, Ming Wu

“…Results During a median follow‐up of 9.77 (9.69, 9.82) years, 3046 deaths were documented, including 922 from cardiovascular disease (CVD) and 736 from cancer. Compared with nonconsumers, regular tea consumption (≥ 3 times/week, 1 cup/day, > 30 years) was associated with reduced all‐cause mortality risk in T2DM, with HRs (95% CIs) of 0.82 (0.74, 0.91), 0.80 (0.72, 0.89), and 0.77 (0.68, 0.86). …”
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Prevalence of Hypertension and Associated Factors in Lubumbashi City, Democratic Republic of Congo: A Community-Based Cross-Sectional Study by Jacques Mbaz Musung, Placide Kambola Kakoma, Clarence Kaut Mukeng, Stéphane Lubamba Tshimanga, Jeef Paul Munkemena Banze, Nathalie Kayomb Kaj, Martin Kazadi Kamuna, Jimmy Kasali Mwamba, Dophra Ngoy Nkulu, Philippe Bianga Katchunga, Olivier Mukuku, Emmanuel Kiyana Muyumba

“…Hypertension is the leading cause of cardiovascular disease morbidity and mortality worldwide. …”
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Echocardiography indicators in patients with atherosclerosis of peripheral arteries of the lower extremities dependent on T(–786)C polymorphism of the endothelial nitric oxide synt... by V.I. Tseluyko, O.D. Yarova

“…Diastolic dysfunction in patients with the second group was associated with a history of cardiovascular disease (CVD) (p = 0.003) and arterial hypertension (AG) (p = 0.03). …”
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Assessment of Vitamin D3 Level Among a Sample of Type 2 Diabetic Patients Attending Diabetes and Endocrinology Center in Al-Hilla City by Ahmed Mahdi Habeeb, Atta Ah Mousa Al-Sarray, Ali Hussein Al Hafidh, Rafah Sabah Barrak, Afraa Brahim

“…Aside from its well-known effects on bone health, vitamin D has been hypothesized to play a role in various disease states and health situations, such as cardiovascular disease and type 2 diabetes. To assess vitamin D3 concentration in patients with type 2 diabetes, using the Vitamin D Total III kit on the Cobas E 411 device. …”
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Death trends for 2010 - 2022 for members of a large private medical scheme in South Africa by L Steenkamp, S Collie, T A Moultrie, H Moultrie, G Gray

“…Malignant neoplasms and cardiovascular disease have been and remained the two leading causes of death for Discovery Health Medical Scheme (DHMS) clients between 2012 and 2022. …”
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Danlian-Tongmai formula improves diabetic vascular calcification by regulating CCN3/NOTCH signal axis to inhibit inflammatory reaction by Wenting Wang, Yiwen Li, Mengmeng Zhu, Qian Xu, Jing Cui, Yanfei Liu, Yanfei Liu, Yue Liu

“…BackgroundVascular calcification (VC) commonly occurs in diabetes and is associated with cardiovascular disease incidence and mortality. Currently, there is no drug treatment for VC. …”
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Correlates of and Body Composition Measures Associated with Metabolically Healthy Obesity Phenotype in Hispanic/Latino Women and Men: The Hispanic Community Health Study/Study of L... by Mayra L. Estrella, Amber Pirzada, Ramon A. Durazo-Arvizu, Jianwen Cai, Aida L. Giachello, Rebeca Espinoza Gacinto, Anna Maria Siega-Riz, Martha L. Daviglus

“…., obesity and absence of cardiometabolic abnormalities: favorable levels of blood pressure, lipids, and glucose) experience lower risk of cardiovascular disease compared with those with “metabolically at-risk obesity” (MAO) phenotype (i.e., obesity with concurrent cardiometabolic abnormalities). …”
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Cost-effectiveness of leveraging existing HIV primary health systems and community health workers for hypertension screening and treatment in Africa: An individual-based modeling s... by Matthew D Hickey, James Ayieko, Jane Kabami, Asiphas Owaraganise, Elijah Kakande, Sabina Ogachi, Colette I Aoko, Erick M Wafula, Norton Sang, Helen Sunday, Paul Revill, Loveleen Bansi-Matharu, Starley B Shade, Gabriel Chamie, Laura B Balzer, Maya L Petersen, Diane V Havlir, Moses R Kamya, Andrew N Phillips

“…<h4>Background</h4>Cardiovascular disease (CVD) morbidity and mortality is increasing in Africa, largely due to undiagnosed and untreated hypertension. …”
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Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults by Malek Mecherques-Carini, Mario Albaladejo-Saura, Francisco Esparza-Ros, Nicolás Baglietto, Raquel Vaquero-Cristóbal

“…Abstract Background Accurate body fat distribution assessment is essential for managing cardiovascular disease and metabolic disorders. Although several methods are available for segmental fat analysis, few studies have examined the validity of affordable methods such as Bioelectrical Impedance Analysis (BIA) against the reference method, Dual-Energy X-ray Absorptiometry (DXA). …”
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Clinical Characteristics and Outcomes of Elderly Patients Undergoing Primary Percutaneous Coronary Intervention: An Observational Cohort Study by Ahmed Hassan, Amr Yosry Emam, Mohammed Thabet, Ahmed Osman, Khaled Ahmed Shams, Mina Samir Labib, Ahmed Elguindy

“…Background: The global trend of population aging has resulted in more frequent cardiovascular disease among seniors. Primary percutaneous coronary intervention (pPCI) is the standard of care for ST-elevation myocardial infarction (STEMI) without an upper age limit. …”
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Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 by Fei Zhang, Fei Zhang, Fei Zhang, Andong Zhang, Andong Zhang, Andong Zhang, Junyue Tao, Junyue Tao, Junyue Tao, Meng Zhang, Meng Zhang, Meng Zhang, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…In addition, this relationship was consistently observed across different subgroups, including individuals with lower education levels, a poverty income ratio (PIR) of 1.5 to 3.5, former smokers, married/living with partner individuals, those with uric acid levels of 5.5 to 6.5 mg/dL, those with hypertension, and those without cardiovascular disease (CVD).ConclusionThis study is the first to find a positive correlation between caffeine intake and BPH, but further research is needed to determine the exact causal relationship between these factors.…”
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Quantitative examination of video-recorded NHS Health Checks: comparison of the use of QRISK2 versus JBS3 cardiovascular risk calculators by Christopher J Gidlow, Sarah Grogan, Lisa Cowap, Elizabeth Cottrell, Ruth Chambers, Naomi J Ellis, Victoria A Riley, Diane Crone, David Clark-Carter

“…Objectives Quantitatively examine the content of National Health Service Health Check (NHSHC), patient–practitioner communication balance and differences when using QRISK2 versus JBS3 cardiovascular disease (CVD) risk calculators.Design RIsk COmmunication in NHSHC was a qualitative study with quantitative process evaluation, comparing NHSHC using QRISK2 or JBS3. …”
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Comprehensive profiling of serum microRNAs in normal and non-alcoholic fatty liver disease (NAFLD) patients by Jian-Wei Zhang, Kamran Ullah, Nauman Khan, Hai-Tao Pan

“…Our study suggests that miR-122 plays a key role in the progression of NAFLD and its associated metabolic disturbances, which can increase the risk of cardiovascular disease. Targeting miR-122 may offer potential therapeutic benefits for improving both liver and heart health in individuals with NAFLD.…”
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Health benefits of pedestrian and cyclist commuting: evidence from the Scottish Longitudinal Study by Paul Kelly, David Walsh, Bruce Whyte, Zhiqiang Feng, Chris Dibben, Graham Baker, Ruth Dundas, Evangelia Demou, Catherine Friel

“…Cox proportional hazard models were used to compare cyclist and pedestrian commuters with non-active commuters for a range of health outcomes, controlling for pre-existing health conditions, and demographic and socioeconomic characteristics.Results Compared with non-active commuting, cyclist commuting was associated with lower all-cause mortality risk (HR 0.53, 95% CI 0.38 to 0.73), lower risk of any hospitalisation (HR 0.90, 95% CI 0.84 to 0.97), lower risk of cardiovascular disease (CVD) hospitalisation (HR 0.76, 95% CI 0.64 to 0.91) and of having a CVD prescription (HR 0.70, 95% CI 0.63 to 0.78), lower risk of cancer mortality (HR 0.49, 95% CI 0.30 to 0.82) and cancer hospitalisation (HR 0.76, 95% CI 0.59 to 0.98), and lower risk of having a prescription for mental health problems (HR 0.80, 95% CI 0.73 to 0.89). …”
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Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity by Zhang Q, Liang D, Zhang C, Ye L, Sun P, Zhu H, Zhao Y, Li Y, Guan Y, Zhang H

“…Multiple studies have shown that an imbalance in the gut-heart axis plays an important role in the development of cardiovascular disease (CVD). We aim to explore the possible correlations between gut microbiota (GM) compositions and cardiometabolic (CM) disorder in MTX-triggered cardiotoxicity mice.Methods: MTX cumulative dose of 6 mg/kg was administered to healthy Kunming male mice to trigger cardiotoxicity, with 1 mg/kg twice weekly for a duration of 3 weeks. …”
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Patients with Age-related Macular Degeneration Have Increased Susceptibility to Valvular Heart Disease by Natan Lishinsky-Fischer, Itay Chowers, MD, PhD, Yahel Shwartz, MSc, Jaime Levy, MD

“…Aortic valve stenosis is the third most common cardiovascular disease in the Western world, after hypertension and coronary artery disease. …”
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Low Serum Magnesium Level Is Associated with Microalbuminuria in Chinese Diabetic Patients by Baihui Xu, Jichao Sun, Xinru Deng, Xiaolin Huang, Wanwan Sun, Yu Xu, Min Xu, Jieli Lu, Yufang Bi

“…After adjustment for age, sex, BMI, blood pressure, lipidaemic profile, HbA1c, eGFR, history of cardiovascular disease, HOMA-IR, antihypertensive and antidiabetic medication, and diabetes duration, we found that, compared with the subjects in tertile 3 of serum magnesium, those in tertile 1 had 1.85 times more likeliness to have microalbuminuria. …”
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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction by Zhi-rong Luo, Han Li, Zhong-xin Xiao, Shui-jin Shao, Tian-tian Zhao, Yue Zhao, Fang-fang Mou, Bo Yu, Hai-dong Guo

“…Cardiovascular disease has been established as a major cause of morbidity and mortality worldwide, resulting in a huge burden to patients, families, and society. …”
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What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation by Katy Cooper, Alan Brennan, David Bagguley, Helen Buckley Woods, Chloe Thomas, Penny Breeze, Michael Gillett, Edward Goka, Hazel Y Squires, Gilly Brenner, Joanna Leaviss, Mark Clowes, Laura Heathcote

“…Objectives To estimate the cost savings and health benefits of improving detection of individuals at high risk of cardiovascular disease (CVD) in England, to determine to which patient subgroups these benefits arise, and to compare different strategies for subsequent management.Design An economic analysis using the School for Public Health Research CVD Prevention Model.Setting England 2018.Participants Adults aged 16 and older with one or more high cardiovascular risk conditions, including hypertension, diabetes, non-diabetic hyperglycaemia, atrial fibrillation, chronic kidney disease and high cholesterol.Interventions Detection of 100% of individuals with CVD high risk conditions compared with current levels of detection in England. …”
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