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    Survey and perspective on verification, validation, and uncertainty quantification of digital twins for precision medicine by Kaan Sel, Andrea Hawkins-Daarud, Anirban Chaudhuri, Deen Osman, Ahmad Bahai, David Paydarfar, Karen Willcox, Caroline Chung, Roozbeh Jafari

    Published 2025-01-01
    “…We examine the critical role of Verification, Validation, and Uncertainty Quantification (VVUQ) for digital twins in ensuring safety and efficacy, with examples in cardiology and oncology. We highlight challenges and opportunities for developing personalized trial methodologies, validation metrics, and standardizing VVUQ processes. …”
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    Absence of Standard Modifiable Risk Factors in Middle Eastern Patients with Atherosclerotic Cardiovascular Disease. The Jordan Absence of Standard Modifiable Risk Factors (SMuRF-Le... by Hammoudeh AJ, Aldalal’ah M, Smadi EA, Alrishoud D, Alomari A, Alkhawaldeh M, Rizik A, Okour MF, Araydah M

    Published 2025-02-01
    “…Ayman J Hammoudeh,1 Mo’men Aldalal’ah,2 Elham A Smadi,2 Dima Alrishoud,2 Amal Alomari,2 Mahmoud Alkhawaldeh,3 Aseel Rizik,4 Mahmoud Fakhri Okour,5 Mohammad Araydah6 1Department of Cardiology, Istishari Hospital, Amman, Jordan; 2Department of Clinical Medical Sciences, Yarmouk University School of Medicine, Irbid, Jordan; 3Department of Internal Medicine, King Abdullah University Hospital, Irbid, Jordan; 4Department of Medical Education, University of Jordan School of Medicine, Amman, Jordan; 5Department of Internal Medicine, Tutanji General Hospital, Amman, Jordan; 6Department of Internal Medicine, Istishari Hospital, Amman, JordanCorrespondence: Ayman J Hammoudeh, Department of Cardiology, Istishari Hospital, 44 Kindi Street, Amman, 11954, Jordan, Tel + 9626 500 1000, Fax + 9626 693 8833, Email a.hammoudeh@istisharihospital.comBackground: A growing number of individuals develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of the standard modifiable risk factors (hypertension, diabetes, dyslipidemia, and cigarette smoking) (SMuRF-less patients). …”
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