CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

“…Chimeric antigen receptor (CAR)-T cell immunotherapy has constituted a revolutionary advance in cancer treatment and exhibited significant potential for application in endocrine cancer. …”
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Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives by Nikolaos Nektarios Karamanolis, Dimitris Kounatidis, Natalia G. Vallianou, Krystalia Dimitriou, Eleni Tsaroucha, Georgios Tsioulos, Ioanna A. Anastasiou, Evangelos Mavrothalassitis, Irene Karampela, Maria Dalamaga

“…This narrative review explores the mechanisms of antibiotics’ anti-cancer activity, addresses controversies about their dual role in cancer biology, and envisions future perspectives that include the development of novel derivatives and innovative frameworks for their incorporation into cancer treatment paradigms.…”
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Experiences of health information-seeking behaviour in preoperative patients with lung cancer: a qualitative study in China by Wei Li, Lihua Huang, Jie Zhu, Jiayi Guo, Man Ye

“…Challenges emerged in comprehending and assessing factors related to lung cancer, treatment alternatives, surgical complications, online media resources and preoperative exercise protocols. …”
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RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway by Xuan-ying Wang, Bo Zhang, Yi Lu, Lu Xu, Yi-jie Wang, Bi-yu Cai, Qing-hua Yao

“…Although first-line chemotherapy drugs, including 5-fluorouracil (5-FU), remain one of the major choice for cancer treatment, the clinical use is also accompanied with dose-depending toxicities, such as intestinal mucositis (IM), in cancer patients undergoing treatment. …”
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Out-of-field dose assessment for pencil beam scanning proton radiotherapy versus photon radiotherapy for breast cancer in pregnant women by Menke Weessies, Murillo Bellezzo, Britt J.P. Hupkens, Frank Verhaegen, Gloria Vilches-Freixas

“…Background and purpose: Cancer affects 1 in 1000–2000 pregnancies annually worldwide, creating challenges in balancing cancer treatment and fetal safety. This study compares out-of-field radiation doses between two treatment modalities: 6MV external photon radiotherapy (XRT) and pencil beam scanning proton-therapy (PBS-PRT) for breast cancer, including imaging, to evaluate PBS-PRT as a potential new treatment option. …”
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Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice by Peng Yu, Weiyin Xu, Yanqi Li, Zhaoyang Xie, Simeng Shao, Jianing Liu, Ying Wang, Long Wang, Hongmei Yang

“…Our results manifested for the first time that Rg3/Rg5-BG exerted its anti-cancer effects: through activation of the caspase-3/Bax/Bcl-2 pathway and by altering the gut microbiome composition, thus paving the way for new therapeutic strategies that incorporate natural products in cancer treatment.…”
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Challenges and adaptations in pancreatic cancer surgery during the COVID-19 pandemic in a high-volume center by Mohammed Al-Saeedi, Ali Ramouz, Elias Khajeh, Sakher Shraim, Alexander Werba, Georgios Polychronidis, Arianeb Mehrabi, Martin Loos

“…Abstract Background The COVID-19 pandemic affected healthcare systems worldwide, disrupting elective surgeries including those for cancer treatment. This study examines the effects of the pandemic on outcomes of pancreatic cancer surgeries at a specialized high-volume surgery center. …”
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Biophysical Insights into Cancer Transformation and Treatment by Jiří Pokorný, Alberto Foletti, Jitka Kobilková, Anna Jandová, Jan Vrba, Jan Vrba, Martina Nedbalová, Aleš Čoček, Andrea Danani, Jack A. Tuszyński

“…Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.…”
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NCAPD3‐mediated AKT activation regulates prostate cancer progression by Yi Zhang, Wanlin Xie, Xicui Zong, Yuanyuan Fang, Jia Ren, Zuolei Jing, Yong Wei, Shan Lu, Qingyi Zhu, Ping Liu

“…Abstract Despite therapeutic improvements in prostate cancer treatment, the recurrence and mortality rates are still high, and the underlying mechanisms still need further study. …”
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<i>In vitro</i> assay of biological activity of a national preparation of macrophage activating factor (GcMAF-RF) by E. V. Levites, S. S. Kirikovich, E. V. Dolgova, A. S. Proskurina, G. S. Ritter, А. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The preparation will be in demand in the field of cancer treatment, and, in addition, it can be used in the treatment of a number of neurodegenerative pathologies.…”
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Evaluation of 3D-CRT Radiotherapy Treatment Planning with Radiobiological Effects in Patient-Specific 3D Printed Anthropomorphic Phantom Postmastectomy Breast Cancer Axillary Metas... by Endarko Endarko, Aditya Hariyanto, Siti Aisyah, Nandia Kavilani, Ahmad Syafi&#039;i

“…Conclusion: This study successfully demonstrated the dosimetry evaluation and radiobiological effects of postmastectomy right breast cancer treatment using a patient-specific 3D printed anthropomorphic phantom, which met the established standards.…”
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Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition by Shuangqian Yan, Panpan Xue, Ying Sun, Tingjie Bai, Sijie Shao, Xuemei Zeng

“…Abstract The dysregulated cholesterol metabolism in breast cancer cells drives malignancy, invasion, and metastasis, emphasizing the significance of reducing abnormal cholesterol accumulation for effective cancer treatment and metastasis inhibition. Despite its promise, cholesterol oxidase (ChOx) encounters challenge due to limited catalytic efficiency and susceptibility to harsh conditions. …”
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation by Na Shao, Lei Xi, Yangfan Lv, Muhammad Idris, Lin Zhang, Ya Cao, Jingyi Xiang, Xi Xu, Belinda X. Ong, Qiongyi Zhang, Xu Peng, Xiaoyan Yue, Feng Xu, Chungang Liu

“…This study reveals a ubiquitination-dependent regulation of YTHDF1, proposing USP5 inhibition alongside PD-(L)1 blockade as a promising cancer treatment strategy.…”
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Clinical profile of patients assisted in a physical therapy outpatient service in oncology of Sao Paulo city by Pascale Mutti Tacani, Karina Tamy Kasawara, Rogério Eduardo Tacani, Aline Fernanda Peres Machado, Débora Montezello, João Carlos Guedes Sampaio Góes

“…Advances in cancer treatment has been favoring higher survival rates, increasing demand of rehabilitation of cancer patients, being physical therapy one of the areas in a higher growth. …”
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Global cervical cancer elimination: quantifying the status, progress, and gaps by Liangru Zhou, Yi Li, Hongyun Wang, Ruixi Qin, Zhen Han, Ruifeng Li

“…We also found that tertiary prevention was achieved in most LMICs, but the indicator-reported annual opioid consumption in oral morphine equivalents indirectly illustrates the under-utilisation of cancer treatment services.…”
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Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells. by Eiman Abdo, Mohammad A Ismail, Sabal Al Hadidi, Mairvat Al-Mrahleh, Tareq Saleh, Malik Zihlif, Nidaa A Ababneh

“…Given that immunotherapy is now approved for pancreatic cancer treatment, further understanding of how pancreatic tumor cell hypoxia influences T-cell cytotoxicityis essential.…”
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Infiltration and subtype analysis of CD3 + CD20 + T cells in lung cancer by Liping Luo, Juan Ji, Juan Dong, Maotao He, Wenjun Jiang, Yang Liu, Weidong Wang

“…This finding could facilitate the advancement of novel cancer treatment strategies.…”
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Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway by Dong T, Li J, Liang X, Wang W, Chen M, Yang G, Wu D

“…Tianwei Dong,1 Jinlian Li,2 Xinfang Liang,3 Wang Wang,3 Meichi Chen,4 Guangyuan Yang,5 Dongmei Wu4 1Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154000, People’s Republic of China; 2College of Pharmacy, Jiamusi University, Jiamusi, Heilongjiang, 154007, People’s Republic of China; 3Department of Cardiology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, 154002, People’s Republic of China; 4School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154000, People’s Republic of China; 5Cardiovascular Medicine, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, 154002, People’s Republic of ChinaCorrespondence: Dongmei Wu; Guangyuan Yang, Email dmwu@jmsu.edu.cn; Ygy665@126.comBackground: Doxorubicin (DOX) is a chemotherapeutic agent widely used for cancer treatment and has non-negligible cardiotoxicity. …”
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An Efficient 3D Convolutional Neural Network for Dose Prediction in Cancer Radiotherapy from CT Images by Lam Thanh Hien, Pham Trung Hieu, Do Nang Toan

“…One of the most commonly used methods for treatment is radiation therapy. However, cancer treatment using radiotherapy is a time-consuming process that requires significant manual work from planners and doctors. …”
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Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy by Runyan Niu, Xuexue Liu, Xian Yang, Xiao Du, Siliang Wang, Xiaolong Ma, Shaoping Yin, Lihua Shao, Jinping Zhang

“…This innovative approach presents new opportunities to enhance both the safety and therapeutic efficacy of cancer treatments. This review comprehensively explores recent progress in the application of PDANSs for cancer therapy. …”
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