Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening by Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell

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Adding Bismuth to Rabeprazole-Based First-Line Triple Therapy Does Not Improve the Eradication of Helicobacter pylori by Meng-Chieh Wu, Yao-Kuang Wang, Chung-Jung Liu, Fang-Jung Yu, Fu-Chen Kuo, Min-Li Liu, Chao-Hung Kuo, Deng-Chyang Wu, Yao-Kang Huang, I-Chen Wu

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Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies by Elisa Monti, Clara Vianello, Ilaria Leoni, Giuseppe Galvani, Annalisa Lippolis, Federica D’Amico, Sara Roggiani, Claudio Stefanelli, Silvia Turroni, Francesca Fornari

“…The development of safe and effective strategies that target the gut–liver axis holds promise for liver cancer prevention and treatment, especially if personalized options will be considered.…”
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Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review by Joshua Lubov, Mathilde Labbé, Krystelle Sioufi, Grégoire B. Morand, Michael P. Hier, Manish Khanna, Khalil Sultanem, Alex M. Mlynarek

“…Abstract Background Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a non-melanoma skin cancer that is mostly caused by solar ultraviolet radiation exposure. …”
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Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy by Khurram Shahzad, Martin Cadeiras, Sarfaraz Memon, Barry Zeeberg, Tod Klingler, Anshu Sinha, Esteban G. Tabak, Sreevalsa Unniachan, Mario C. Deng

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Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters by Mrozikiewicz Przemyslaw M., Bogacz Anna, Bartkowiak-Wieczorek Joanna, Kujawski Radoslaw, Mikolajczak Przemyslaw L., Ozarowski Marcin, Czerny Boguslaw, Mrozikiewicz-Rakowska Beata, Grzeskowiak Edmund

“…Extract from the aerial parts of Hypericum perforatum L. was the only one to cause an increased mRNA level for mdr1 and oatp1c1. …”
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Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development by Corina Toma, Roxana Popa, Lidia Ciobanu, Ioana Baldea, Irina Amorim, Diana Bochynska, Alan Wolfe, Andrada Negoescu, Claudiu Gal, Marian Taulescu

“…Abstract Background Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte sheep retrovirus (JSRV) and is considered an important potential animal model for human lung cancer. …”
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Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review by Li Zhu, Mengchen Tang, Yinyin Cai, Yinyin Cai, Panpan Wang, Panpan Wang

“…It is also associated with adverse inflammatory responses and tissue damage in periodontal tissues by causing oxidative stress, potentially leading to periodontitis. …”
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Exploring the prevalence of gout among underrepresented low socioeconomic status type 2 diabetes populations by Jessica Smith, Abey Martin, Jane Mundadan, Michael Roberts, Youssef Roman, Arturo Bravo-Nuevo, Farzaneh Daghigh

“…Exclusion criteria were a personal history of cancer, organ transplantation, or current pregnancy. …”
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BTEX Exposure Assessment and Inhalation Health Risks to Traffic Policemen in the Klang Valley Region, Malaysia by Noor Fatihah Mohamad Fandi, Juliana Jalaludin, Mohd Talib Latif, Haris Hafizal Abd Hamid, Mohd Fairus Awang

“…Abstract Benzene, toluene, ethylbenzene, m,p-xylene, and o-xylene (collectively referred to as BTEX), which are prevalent in the ambient air of urban environments, potentially cause chronic health effects, particularly among outdoor workers. …”
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Beneficial Effects of <i>In Vitro</i> Reconstructed Human Gut Microbiota by Ginseng Extract Fermentation on Intestinal Cell Lines by Margherita Finazzi, Federica Bovio, Matilde Forcella, Marina Lasagni, Paola Fusi, Patrizia Di Gennaro

“…Oxidative stress caused by reactive oxygen species (ROS) affects the aging process and increases the likelihood of several diseases. …”
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Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model by Chun-Yan Yeung, Jen-Shiu Chiang Chiau, Mei-Lien Cheng, Wai-Tao Chan, Szu-Wen Chang, Chuen-Bin Jiang, Hung-Chang Lee

“…Intestinal mucositis remains one of the most deleterious side effects in cancer patients undergoing chemotherapy. We hypothesize that the probiotics could preserve gut ecology, ameliorate inflammation, and protect epithelia via immune modulations of enterocytes and intestinal stem cells. …”
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The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia by Ilia Beliakov, Maria Senina, Yuriy Tyulenev, Elena Novoselova, Viktor Surovtsev, Alexander Guschin

“…Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. …”
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Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs by Abubakar Danmaigoro, Gayathri Thevi Selvarajah, Mohd Hezmee Mohd Noor, Rozi Mahmud, Md Zuki Abu Bakar

“…This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical’s release. …”
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Lentinan's effect on gut microbiota and inflammatory cytokines in 5-FU-induced mucositis mice by Xiaoxiao Zhang, Liang Wang, Asif Iqbal Khan, Ata Ur Rehman, Kavish Hasnain Khinsar, Yi Xin

“…Abstract Chemotherapeutic therapies for cancer are frequently associated with cytotoxic side effects that can be harmful to human health, including the development of intestinal mucositis (IM). …”
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The impact of weight change on suicide mortality: a nationwide population-based cohort study of 2 million Koreans by Kyuho Kim, Jin-Hyung Jung, Yoo Hyun Um, Yu-Bae Ahn, Seung-Hyun Ko, Kyungdo Han, Jae-Seung Yun

“…Abstract Background Previous studies have shown that weight change has a reverse J-shape association with all-cause mortality. However, its association with suicide mortality remains undetermined. …”
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Factors Affecting Male Involvement in Family Planning at Kazo Health Center IV in Kazo Town Council Kazo District. by Ndyaguma, Laban

“…Among the views pointed out by the respondent's on men's participation in family planning as highlighted in the study also agreed with the related literature like culture factors, religious beliefs, social economic factors and psychological factors, Also suggested some other reasons like Ignorance lack of time false myth and fear of family planning side effects as mentioned by the majority of respondents as discussed during a focus group discussion where they mentioned that condoms cause cancer. Men need more information and education so that they can fully participate in family planning services, support their partners and utilize the services and that Health care providers should conduct workshops or hold social gatherings and inform men about family planning and its importance. …”
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Safety and efficacy of immune checkpoint inhibitors in patients with pre-treatment reduced left ventricular function by Maor Tzuberi, Rafael Y. Brzezinski, Nir Flint, Moaad Slieman, Lior Zornitzki, Dana Viskin, Anna Rozenfeld Hemed, Barliz Waissengrin, Renana Barak, Inbal Golomb, Ido Wolf, Netanel Golan, Yan Topilsky, Shmuel Banai, Livia Kapusta, Michal Laufer-Perl

“…Abstract Aims Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment outcomes. However, the response varies across different populations, and their use may lead to life-threatening cardiovascular (CV) events. …”
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Association between lifestyle risk factors and mortality in the Mexico City prospective study by Paloma Ferrero-Hernández, Gary O’Donovan, Fanny Petermann-Rocha, Diego G. D. Christofaro, Carlos Cristi-Montero, Adilson Marques, Marcelo de Maio Nascimento, Claudio Farías-Valenzuela, Leandro F. M. Rezende, Gerson Ferrari

“…Multivariable Cox regression models were used to estimate the associations of lifestyle risk factor score (ranging from 0 to 5) with all-cause and cause-specific mortality (cardiovascular disease, renal or hepatobiliary diseases, diabetes, respiratory diseases, cancer and all-cause mortality). …”
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

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