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141
The systemic evolutionary theory of the origin of cancer (SETOC): an update
Published 2025-01-01“…Abstract The Systemic Evolutionary Theory of the Origin of Cancer (SETOC) is a recently proposed theory founded on two primary principles: the cooperative and endosymbiotic process of cell evolution as described by Lynn Margulis, and the integration of complex systems operating in eukaryotic cells, which is a core concept in systems biology. …”
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142
In vivo trafficking of cancer-derived exosomes and their role in metastasis
Published 2025-06-01“…Cancer metastasis is one of the leading causes of cancer-related mortality. …”
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143
Natural products as part of triple negative breast cancer
Published 2025-01-01“…Triple negative breast cancer (TNBC) continues to be the breast cancer subtype with the highest recurrence and mortality rates. …”
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144
Mortality Burden of Cancer of the Lip, Oral Cavity and Pharynx
Published 2022-12-01“…The universe was made up of all deaths from cancer of the lip, oral cavity and pharynx for the years studied. …”
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145
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146
CALR ins5-mediated clonal hematopoiesis causes severe hemolytic anemia in a female PGK1 Ser320Asn carrier
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147
The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients
Published 2018-01-01“…Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. …”
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148
Hybrid discrete-continuous model of invasive bladder cancer
Published 2013-03-01“…This type of cancer starts in theurothelium and progresses towards surroundingmuscles and tissues, causing metastatic disease.Our mathematical model of invasive BC consists of two coupledsub-models: (i) living cycle of the urothelial cells (normal and mutated) simulatedusing discrete technique of Cellular Automata and (ii) mechanism oftumor invasion described by the system of reaction-diffusionequations. …”
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149
Pre-clinical study of curcumin in the treatment of gastric Cancer
Published 2025-02-01“…Gastric cancer is the fifth most common cancer globally and the third leading cause of cancer-related deaths. …”
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150
Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker
Published 2025-01-01“…It has emerged as a biomarker not only for iron-related disorders but also for inflammatory diseases and conditions in which inflammation plays a key role, including cancer, neurodegeneration, and infection. Oxidative stress, which can cause cellular damage, is induced by reactive oxygen species generated during the Fenton reaction, activating signaling pathways associated with tumor growth and proliferation. …”
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151
Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies
Published 2025-04-01“…Colorectal cancer (CRC) has an incidence rate of 10 % and is the third most common cause of mortality worldwide, following breast and lung cancer. …”
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152
Treatment of oligometastatic breast cancer: The role of patient selection
Published 2025-02-01“…Up to 90 % of death from solid tumors are caused by metastases. By 2040, breast cancer (BC) is predicted to increase to over 3 million new cases. …”
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153
Active Roles of Tumor Stroma in Breast Cancer Metastasis
Published 2012-01-01“…Metastasis is the major cause of death for breast cancer patients. Tumors are heterogenous cellular entities composed of cancer cells and cells of the microenvironment in which they reside. …”
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154
Midregion PTHrP and Human Breast Cancer Cells
Published 2010-01-01“…The midregion PTHrP domain (38-94)-amide was found to restrain growth and invasion in vitro of some breast cancer cell lines, causing striking toxicity and accelerating death; the most responsive being MDA-MB231, whose tumorigenesis was also attenuated in vivo. …”
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155
Reproductive Late Effects in Female Survivors of Childhood Cancer
Published 2012-01-01“…Childhood cancer treatments can cause female reproductive late effects. …”
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156
DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
Published 2016-01-01“…Thus, tweaking the epigenetic machinery may help cause or cure diseases, especially cancer. Therefore, cancer epigenetics, especially at a molecular level, needs to be scrutinised closely, as it could potentially serve as the future pharmaceutical goldmine against neoplastic diseases. …”
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157
MicroRNAs in the DNA Damage/Repair Network and Cancer
Published 2014-01-01“…Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. …”
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158
Lung cancer classification with Convolutional Neural Network Architectures
Published 2021-02-01“… One of the most common malignant tumors in the world today is lung cancer, and it is the primary cause of death from cancer. …”
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159
Helicobacter pylori and gastric cancer: mechanisms and new perspectives
Published 2025-01-01“…Our investigation of the molecular mechanisms reveals a complex network involving STAT3, NF-κB, Hippo, and Wnt/β-catenin pathways, which are dysregulated in gastric cancer caused by H. pylori. Furthermore, we highlight the role of H. pylori in inducing oxidative stress, DNA damage, chronic inflammation, and cell apoptosis—key cellular events that pave the way for carcinogenesis. …”
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160
Pancreatic Cancer: Current Concepts, Trends, and Future Directions
Published 2025-02-01“…Epidemiological studies project that it will become the second leading cause of cancer-associated mortalities in the following decades. …”
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