Barrett’s Esophagus: Is It All That Bad? by GNJ Tytgat

“…Because superficial cancers only rarely cause symptoms, detection of cancer at such an early curable state can only be achieved through surveillance of patients at risk. …”
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Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis by Zeli Tang, Zeli Tang, Zeli Tang, Caibiao Wei, Xueling Deng, Qiumei Lin, Qiping Hu, Qiping Hu, Qiping Hu, Shitao Li, Jilong Wang, Yuhong Wu, Dengyu Liu, Dengyu Liu, Dengyu Liu, Min Fang, Min Fang, Tingzheng Zhan, Tingzheng Zhan, Tingzheng Zhan

“…The influence of C. sinensis on serum proteome and metabolome in HCC was further assessed.ResultC. sinensis infection correlated with a younger age at cancer onset, male predominance, advanced cancer stage, liver cirrhosis, and microvascular invasion in HCC patients. …”
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Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population by Lung-An Hsu, Ming-Sheng Teng, Semon Wu, Mei-Siou Liao, Hsin-Hua Chou, Yu-Lin Ko

“…Using Kaplan-Meier survival and Cox regression analyses, participants with progressively increasing resistin levels had a higher hazard ratio for all-cause mortality and cancer mortality compared to those with lower resistin levels. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Radiofrequency ablation combined with immunotherapy to treat hepatocellular carcinoma: a comprehensive review by Gui-Lin Xie, Zhi-Han Zhong, Tai-Wei Ye, Zun-Qiang Xiao

“…Abstract Background and aim Hepatocellular carcinoma (HCC) is a highly immunogenic tumor and the third leading cause of cancer-related deaths worldwide with an increasing incidence. …”
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Associations between systemic inflammatory biomarkers and metabolic dysfunction associated steatotic liver disease: a cross-sectional study of NHANES 2017–2020 by Xin Qiu, Shuang Shen, Nizhen Jiang, Yifei Feng, Guodong Yang, Donghong Lu

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In silico evaluation, characterization, and in vitro anticancer activity of curcumin–nimbin loaded nanoformulation in HCT-116 cell lines by Arumugam Madeswaran, Selvam Tamilazhagan, Sellappan Mohan

“…Colorectal cancer is one of the most prevalent malignancies worldwide and a leading cause of mortality. …”
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Metastatic Lesion of the Tibia from Renal Cell Carcinoma by Piotr Młodożeniec, Krzysztof Balawender, Mateusz Zasadny

“…Additionally, the patient was enrolled to sunitinib treatment and was disease free at one year of follow-up. 13 months after diagnosis of cancer, she was suffering a major stroke of the brain that caused her to die. …”
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New Strategies and In Vivo Monitoring Methods for Stem Cell-Based Anticancer Therapies by Ping Wang, Aitor Aguirre

“…Cancer is a devastating disease and the second cause of death in the developed world. …”
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Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant by Alexander Augustyn, Mona Lisa Alattar, Harris Naina

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TLRs, Alcohol, HCV, and Tumorigenesis by Keigo Machida

“…Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). …”
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Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia by Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios-Athanasios C. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Jeffrey V. Matous

“…Abstract: Peripheral neuropathy (PN) is a significant cause of morbidity associated with Waldenström macroglobulinemia (WM). …”
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The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability by Emily Graham, Lucia Rampazzo, Chin Wei Brian Leung, Jacob Wall, Emőke Zsanett Gerőcz, Mikhail Liskovykh, Nikolay Goncharov, Xanita Saayman, Ramazan Gundogdu, Masato T. Kanemaki, Hiroshi Masumoto, Vladimir Larionov, Natalay Kouprina, Fumiko Esashi

“…Conversely, PALB2 does not affect CENP-A, whereas its depletion increases centromeric DNA breaks in non-cancerous cells only. Interestingly, depleting the mismatch repair (MMR) factor MLH1 masks centromere fragility caused by BRCA2 or PALB2 loss, suggesting that MLH1 contributes to DNA instability when BRCA2 or PALB2 is absent. …”
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Optimism and Mortality in Older Men and Women: The Rancho Bernardo Study by Ericha G. Anthony, Donna Kritz-Silverstein, Elizabeth Barrett-Connor

“…To examine the associations of optimism and pessimism with all-cause, cardiovascular disease (CVD), coronary heart disease (CHD), and cancer mortality in a population-based sample of older men and women followed ≤12 years. …”
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Association of serum high-sensitivity C reactive protein with risk of mortality in an Asian population: the Health Examinees cohort by Jong-Koo Lee, Daehee Kang, Sang-Ah Lee, Xiao-Ou Shu, Sung Ok Kwon, Hyerim Park

“…The association of serum hsCRP with risk of cancer mortality was not observed in women with NCDhistory, but the association with risk of cardiovascular disease (CVD) mortality was predominantly observed in men with NCDhistory.Conclusions This study suggests a dose–response association of hsCRP with mortality risk, including cancer and CVD mortality, in Koreans with low serum hsCRP, although the association with cancer and CVD mortality risk could be influenced by gender and NCDhistory.…”
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Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…Abstract Alcohol‐related liver disease (ALD) is a common chronic liver disease caused by long‐term excessive alcohol consumption and responsible for more than half of all liver‐related deaths worldwide. …”
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Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment by Pingping Feng, Pingping Feng, Xinyang Hu, Xinyang Hu, Sining Zhou, Xianyong Liu, Linghui Zeng, Yiming Liu, Yiming Liu, Yiming Liu, Yiming Liu

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Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study by Vin-Cent Wu, Ting-Ya Yang, Min-Hsiang Chuang, Hong-Min Lin, Heng-Chih Pan, Yun Chou, Jui-Yi Chen

“…Subgroup analyses confirmed these findings across various patient’s characteristics.Conclusion Individuals with ICPi-AKI are associated with an increased risk of all-cause mortality, MAKE and MACE. Enhancing awareness and timely intervention for ICPi-AKI are crucial for improving prognosis and reducing complications among patients with cancer.…”
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Unlocking the potential of gold nanoparticles as a game-changer in the fight against hepatocellular carcinoma by Sarmistha Saha, Manas Taneja, Sneha Dubey, Alok Bhardwaj

“…According to research, hepatocellular carcinoma (HCC), ranks third globally in terms of cause of death and is the fifth most common type of cancer overall. …”
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MTIOT: Identifying HPV subtypes from multiple infection data by Qi Zhao, Tianjun Zhou, Lin Li, Guofan Hong, Luonan Chen

“…Persistent infection with high-risk human papillomavirus (hrHPV) is a major cause of cervical cancer. The effectiveness of current HPV-DNA testing, which is crucial for early detection, is limited in several aspects, including low sensitivity, accuracy issues, and the inability to perform comprehensive hrHPV typing. …”
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