Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…The most common cancers were breast cancer and soft tissue sarcoma in females, and soft tissue sarcoma and prostate cancer in males. …”
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The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells by Yun Zhao, Shanel Dhani, Vladimir Gogvadze, Boris Zhivotovsky

“…Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. …”
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SELENOF gene as a quintessential target in oral squamous cell carcinoma by Ramya Ramadoss, Monal Yuwanati, Abigail Viola E, Pradeepkumar Yadalam, Pratibha Ramani, Sindhu Ramesh

“…Goal of the Perspective: Antioxidant mechanism are irreversibly damaged and cause cellular and genetic changes in oral cancer. …”
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A Challenging Case of Metastatic Intra-Abdominal Synovial Sarcoma with Unusual Immunophenotype and Its Differential Diagnosis by Yi-Che Changchien, Uhrin Katalin, János Fillinger, László Fónyad, Gergő Papp, Ferenc Salamon, Zoltán Sápi

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Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature by William Forehand III, Germame Ajebo, Michael Toscano, Anand Jillella, Paul Dainer

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Targeted Therapy in Hepatocellular Carcinoma by Clarinda W. L. Chua, Su Pin Choo

“…Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, as well as a common cause of cancer-related death. …”
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The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…Breast cancer is one of the most common cancers among females and is associated with high mortality and morbidity rates. …”
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An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance by Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng

“…Therapeutic resistance is a major challenge in clinical cancer theranostics, often leading to treatment failure and increased patient mortality. …”
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Integrated proteogenomic characterization of ampullary adenocarcinoma by Qiao Zhang, Xiaomeng Xu, Dongxian Jiang, Yunzhi Wang, Haixing Wang, Jiajun Zhu, Shaoshuai Tang, Ronghua Wang, Shuang Zhao, Kai Li, Jinwen Feng, Hang Xiang, Zhenmei Yao, Ning Xu, Rundong Fang, Wenjia Guo, Yu Liu, Yingyong Hou, Chen Ding

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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Previously, we have reported that glomeruli and proximal tubules with diabetic nephropathy express toll-like receptor TLR2/4, and that the TLR ligand lipopolysaccharide (LPS) of periodontal pathogens have caused nephropathy in diabetic model mice. Recently, many researchers suggested that the periodontal pathogenic bacteria Fusobacterium (F.) nucleatum has the TLR4-associated strong activator of the colorectal inflammation and cancer. …”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…To present the modern concept on the causes and pathogenesis of pancreatic exocrine insufficiency (PEI) as well as the new diagnostic and therapeutic approaches at this syndrome to general practitioners. …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

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Aflatoxins in Uganda: An Encyclopedic Review of the Etiology, Epidemiology, Detection, Quantification, Exposure Assessment, Reduction, and Control by Timothy Omara, Winfred Nassazi, Tom Omute, Aburu Awath, Fortunate Laker, Raymond Kalukusu, Bashir Musau, Brenda Victoria Nakabuye, Sarah Kagoya, George Otim, Eddie Adupa

“…More efforts should be geared towards awareness creation and vaccination against hepatitis B and hepatitis A to reduce the risk of development of liver cancer among the populace.…”
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Cohort profile: the ChicagO Multiethnic Prevention and Surveillance Study (COMPASS) by Habibul Ahsan, Farzana Jasmine, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Liz Stepniak, Rajan Gopalakrishnan, Andrew Craver, Paul Zakin, Saira Tasmin, Karen E Kim, Kathleen H Goss, Marcy List, Michelle LeBeau

“…Purpose The ChicagO Multiethnic Prevention and Surveillance Study or ‘COMPASS’ is a population-based cohort study with a goal to examine the risk and determinants of cancer and chronic disease. COMPASS aims to address factors causing and/or exacerbating health disparities using a precision health approach by recruiting diverse participants in Chicago, with an emphasis on those historically underrepresented in biomedical research.Participants Nearly 8000 participants have been recruited from 72 of the 77 Chicago community areas. …”
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Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…Zhan Wang,1,* Pengpeng Zhang,2,* Run Shi,3,* Shuai Yang,1 Kui Liu,4 Zhaokai Zhou,1 Qi Li5 1Pediatric Urodynamic Center, Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, 450052, People’s Republic of China; 2Department of Lung Cancer, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China; 3Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Pediatric Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471000, People’s Republic of China; 5Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaokai Zhou, Pediatric Urodynamic Center, Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, 450052, People’s Republic of China, Email 13526278113@163.com Qi Li, Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China, Email siloam1994@163.comBackground: Nocturnal enuresis (NE) and obstructive sleep apnea (OSA) are common diseases in children, which often cause various social and psychological problems. …”
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Anterior Uveitis as an Initial Manifestation of Polymyalgia Rheumatica by Hiromasa Tsuda, Kozue Tanaka, Shuji Kishida

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Deep learning for stage prediction in neuroblastoma using gene expression data by Aron Park, Seungyoon Nam

“…Neuroblastoma is a major cause of cancer death in early childhood, and its timely and correct diagnosis is critical. …”
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LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis. by Lin Zhu, Qianqian Meng, Weiyi Qian, Weiting Shao, Yuyue Lu, Shuai Jin, Afei Zhang, Shuang G Yan, Jingtao Lu

“…Primary hepatocellular carcinoma (PHC) is the sixth most common cancer and the third leading cause of cancer death worldwide. …”
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Everolimus Implicated in Case of Severe Gastrointestinal Hemorrhage by Paul Gonzales, Seth Klusewitz, Johanna Marowske, John Gancayco, Michael B. Osswald, Robert Setlik

“…Breast cancer remains the leading cause of cancer and the third leading cause of cancer related deaths among our population with an estimated number of 246,660 new cases and 40,450 deaths in 2016. …”
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<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…In Russia, cancer is the second leading cause of death following cardiovascular diseases. …”
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