Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by Graham McIlroy, Charlotte Gaskell, Aimee Jackson, Emily Yafai, Rachel Tasker, Catherine Thomas, Sonia Fox, Rebecca Boucher, Fitsum Ghebretinsea, Claire Harrison, Adam J. Mead, Mary Frances McMullin

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Clinical integration of germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina C. Anggala, Brittany Gillies, Kirsten M. Farncombe, Renee Hofstedter, Larissa Peck, Helia Purnaghshband, Laura Redondo, Emily Thain, Wei Xu, Peter Sabatini, Philippe L. Bedard, Raymond H. Kim

“…Eligibility for hereditary cancer syndrome investigation (‘germline criteria’) followed Cancer Care Ontario’s Hereditary Cancer Testing Criteria and clinical judgment. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

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Melanoma Disparities among US Hispanics: Use of the Social Ecological Model to Contextualize Reasons for Inequitable Outcomes and Frame a Research Agenda by Valerie M. Harvey, Charlene W. Oldfield, Jarvis T. Chen, Karl Eschbach

“…Currently, there is a paucity of literature investigating the root causes underlying these trends among Hispanics. Given that Hispanics are the most rapidly expanding demographic segment in the US, it is essential for cancer control efforts to elucidate the major determinants of their poor melanoma outcomes. …”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

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Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

“…Immune checkpoint inhibitor (ICI) therapy is a cornerstone treatment for many cancers, but it can induce severe immunotoxicity, including acute interstitial nephritis (AIN). …”
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An Anaplastic Lymphoma Kinase-positive Inflammatory Myofibroblastic Tumor with Rapidly Acquired Resistance to First-line Anaplastic Lymphoma Kinase Inhibitor: A Case and Literature... by Shu-Cheng Wu, Hsing-Wu Chen

“…Approximately half of IMTs are positive for an anaplastic lymphoma kinase (ALK) gene rearrangement which causes aberrant expression. Early phase clinical trials have demonstrated the efficacy of ALK inhibitors in the treatment of IMTs. …”
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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

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Recent updates of centromere proteins in hepatocellular carcinoma: a review by Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu

“…Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, with approximately 800,000 deaths worldwide each year. …”
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Successful Diagnosis and Management of Superior Orbital Fissure Syndrome Secondary to Lung Adenocarcinoma: A Case Report by Wang Y, Zhao X

“…It also demonstrates the efficacy of localized radiotherapy in treating such uncommon presentations of lung cancer metastasis.Keywords: superior orbital fissure syndrome, lung adenocarcinoma, metastasis, radiotherapy, case report…”
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Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells by Katarzyna Stasiak, Aaron D. Stevens, Ashley C. Bolte, Colleen T. Curley, Mirna Perusina Lanfranca, Robin S. Lindsay, Ukpong B. Eyo, John R. Lukens, Richard J. Price, Timothy N. J. Bullock, Victor H. Engelhard

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Fractionated radiotherapy initiated at the early stage of bone metastasis is effective to prolong survival in mouse model by Yun Zhang, Zhunyi Gao, Ziwei Qi, Jiahe Xu, Jiao Xue, Lujie Xiong, Junhui Wang, Yuhui Huang, Songbing Qin

“…Background and purpose Bone metastasis is common for breast cancer and associated with poor prognosis. Currently, radiotherapy (RT) serves as the standard treatment for patients exhibiting symptoms of bone metastasis to alleviate pain. …”
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Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study by Malte Beckmann, Julian Schlüter, Michael Erdmann, Rafaela Kramer, Sarah Cunningham, Holger Hackstein, Robert Zimmermann, Lucie Heinzerling

“…Recent reports suggest a correlation between ICI-induced systemic inflammation and thromboembolic events as well as an increased effectiveness by coadministration of anticoagulants. With cancer patients having a higher risk of thrombotic events per se, it is crucial to dissect and characterize the mechanisms that cause pro-coagulative effects induced by systemic tumor therapies and their potential interplay with anti-tumor response. …”
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Targeting the NLRP3 inflammasome abrogates cardiotoxicity of immune checkpoint blockers by Ping Li, Zhen Qin, Yang Lu, Jiamin Gao, Zhenwei Wang, Ge Zhang, Han Yang, Yachen Hou, Dashuai Wang, Pengchong Du, Yunzhe Wang, Quanzhou Chen, Zhaowei Sun, Jinying Zhang, Junnan Tang

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Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…Background Polyclonal autologous T cells that are epigenetically reprogrammed through mTOR inhibition and IFN-α polarization (RAPA-201) represent a novel approach to the adoptive T cell therapy of cancer. Ex vivo inhibition of mTOR results causes a shift towards T central memory (TCM) whereas ex vivo IFN-α promotes type I cytokines, with each of these functions known to enhance the adoptive T cell therapy of cancer. …”
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Rapid corticosteroid taper versus standard of care for immune checkpoint inhibitor induced nephritis: a single-center retrospective cohort study by Ryan Sullivan, Riley Fadden, Kerry L Reynolds, Meghan D Lee, Harish Seethapathy, Ian A Strohbehn, Sophia H Zhao, Genevieve M Boland, Meghan E Sise

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Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15 by Xin Xu, Shantan Reddy, Saleh Bhar, Frederic D Bushman, Amy N Courtney, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa, Antonino Montalbano, Hangjin Yu, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Aoife M Roche, David de la Cerda, Donald Williams Parsons, Andras Heczey

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Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis by Yan Liu, Junjie Liu, Qin Wang, Kun Zhang, Chunyan Zhu, Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Chao Fang

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A Review on Automatic Mammographic Density and Parenchymal Segmentation by Wenda He, Arne Juette, Erika R. E. Denton, Arnau Oliver, Robert Martí, Reyer Zwiggelaar

“…However, the exact cause(s) of breast cancer still remains unknown. …”
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Efficacy Analysis of Hypofractionated Radiotherapy for Oligometastatic Tumors: A Retrospective Study by Qian Sun MD, Hanqing Zhao MS, Xianwen Zhang MS, Suli Zhang MS, Zelai He MD, Gengming Wang MD, Hao Jiang MS, Aili Xuan MS, Xianming Li MD

“…Introduction Metastasis remains a major cause of death among patients with malignant tumors. …”
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