Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells by Stefanie Hoyer, Kerstin F. Gerer, Isabell A. Pfeiffer, Sabrina Prommersberger, Sandra Höfflin, Tanushree Jaitly, Luca Beltrame, Duccio Cavalieri, Gerold Schuler, Julio Vera, Niels Schaft, Jan Dörrie

“…None of those RNAs induced changes in the expression of CD25, CD40, CD83, CD86, and CD70 or the secretion of the cytokines IL-8, IL-6, and TNFα of more than 1.5-fold compared to the control condition, while an mRNA encoding an NF-κB-activation protein as positive control induced massive secretion of the cytokines. …”
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Upregulated Expression of Indoleamine 2, 3-Dioxygenase in Primary Breast Cancer Correlates with Increase of Infiltrated Regulatory T Cells In Situ and Lymph Node Metastasis by Jinpu Yu, Jingyan Sun, Shizhen Emily Wang, Hui Li, Shui Cao, Yizi Cong, Juntian Liu, Xiubao Ren

“…We further demonstrated that CD4+CD25+CD127− Tregs could be amplified by coculturing CD3+ T cells with IDO/CHO cells in vitro which displayed increasing Foxp3 expression both at mRNA and protein levels. …”
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Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure by Yao Yao, Yanli Li, Qinchun Jin, Xiaoye Li, Xiaochun Zhang, Qianzhou Lv

“…The biochemical indicators, thrombin-antithrombin complex (TAT), soluble P-selectin (sP-selectin), von Willebrand factor (vWF), and CD40 ligand (CD40L), were measured by enzyme-linked immunosorbent assay. …”
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Evaluating the usefulness of plasma chromogranin A measurement in cyclic ACTH-dependent Cushing’s syndrome by Keisuke Kakizawa, Miho Yamashita, Yuto Kawauchi, Akira Ikeya, Kenji Ohba, Akio Matsushita

“…The measurement of plasma chromogranin A levels could aid in differentiating EAS from CD.…”
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Low Distribution of TIM-3+ Cytotoxic Tumor-Infiltrating Lymphocytes Predicts Poor Outcomes in Gastrointestinal Stromal Tumors by Chun Zhuang, Bo Ni, Zi-Zhen Zhang, Wen-Yi Zhao, Lin Tu, Xin-Li Ma, Lin-Xi Yang, Hui Cao, Ming Wang

“…The integrated analysis of TIM-3+, CD8+, and CD56+ TILs as one biomarker is a reliable independent predictor of prognosis. …”
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The Selection of Anode and Cathode Materials for Top Emission Organic Light-Emitting Diodes by Fuh-Shyang Juang, Krishn Das Patel, Kuo-Chun Huang, Wen-Xaing Juang, Jeng-Yue Chen, Lin-Ann Hong

“…At 8 V, the luminance is increased to 413.7 cd/m2, and the current efficiency is 0.81 cd/A. …”
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Predicting cadmium enrichment in crops/vegetables and identifying the effects of soil factors based on transfer learning methods by Rui Chen, Zean Liu, Jingyan Yang, Tiantian Ma, Aihong Guo, Rongguang Shi

“…Cadmium (Cd) is present in soils and can easily migrate into plants due to its various forms. …”
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Assessment of Patients’ Future Outlook after Bowel Resection in Crohn’s Disease by Shasha Tang, Xiaolong Ge, Weilin Qi, Wei Liu, Qian Cao, Wei Zhou

“…Many patients with Crohn’s disease (CD) require surgery in their life. Their future outlook is crucial to psychological and mental health after surgery. …”
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Analysis of the Concentration of Heavy Metals in Khat Grown in Meru County and the Assessment of Their Associated Health Risks by Albert M. Oyugi, Joshua K. Kibet, John O. Adongo

“…Based on the results, the mean levels of Pb, Cd, and Cr exceeded WHO permissible limits. In addition, the Pb and Cd THQ values and the HI of the six heavy metals investigated in the khat samples exceeded the threshold value of 1.0. …”
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Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner by Bojana Simovic Markovic, Marina Gazdic, Aleksandar Arsenijevic, Nemanja Jovicic, Jovana Jeremic, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L. Lukic, Vladislav Volarevic

“…MSC treatment significantly attenuated influx of leukocytes, macrophages, dendritic cells (DCs), neutrophils, CD4+ T helper (Th), and CD8+ cytotoxic T lymphocytes (CTLs) in damaged kidneys and attenuated the capacity of renal-infiltrated DCs, CD4+ Th, and CD8+ CTLs to produce TNF-α and IL-17. …”
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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

“…IntroductionCrohn’s disease (CD) results from alterations in the gut microbiota and the immune system. …”
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ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-/- Mouse through Promoting M2 Macrophage Polarization by Yong You, Xiaoqing Zhang, Xiao Wang, Dan Yue, Fanxiang Meng, Junfeng Zhu, Yuanyuan Wang, Xun Sun

“…The results showed that ILC2 reached a proliferation peak at day 5 and expressed multiple surface markers like CD127, C-kit, CD69, CD44, ST2, CD27, DR3, MHCII, and CD90.2. …”
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Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Tiina E. Kähkönen, Mari I. Suominen, Jenni H. E. Mäki-Jouppila, Jussi M. Halleen, Azusa Tanaka, Michael Seiler, Jenni Bernoulli

“…Bone lesions appeared earlier and were larger, and bone mineral density was higher in huNOG mice. huNOG mice had a high number of human CD3-, CD4-, and CD8-positive T cells and CD20-positive B cells in immune-related organs. …”
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RL-ADN: A high-performance Deep Reinforcement Learning environment for optimal Energy Storage Systems dispatch in active distribution networks by Shengren Hou, Shuyi Gao, Weijie Xia, Edgar Mauricio Salazar Duque, Peter Palensky, Pedro P. Vergara

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Carcinogenic and non-carcinogenic human health risk assessment of some vegetables irrigated with wastewater in Jos, Plateau State, Nigeria by Usman Bawa, Ahmad AbdulHameed

“…The metals of interest were Cd, Pb, Cr, Cu, and Zn. Results: Concentrations of Cd, Pb, and Cr in all the vegetables exceeded the WHO’s permissible limits while Cu and Zn did not. …”
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Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease by Shinichi Hashimoto, Kensaku Shimizu, Hiroaki Shibata, Satoko Kanayama, Ryo Tanabe, Hideko Onoda, Naohumi Matsunaga, Isao Sakaida

“…When determining therapeutic strategy, it is important to diagnose small intestinal lesions in Crohn's disease (CD) precisely and to evaluate mucosal healing as well as clinical remission in CD. …”
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Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma by Leonard D’Amico, Martin Cheever, Steven P Fling, Anna Wright, Kathryn Lurain, Ramya Ramaswami, Irene Ekwede, Thomas S Uldrick, Robert Yarchoan, Judith C Kaiser, Angela Shaulov Kask, Manoj P Menon, Paul Couey, Eli Burnham, Allysson Angeldekao, Byung Ha Lee, Li-Lian Kwok, Chia-Ching Jackie Wang

“…Background CD4+ T-cell lymphocytopenia and immune dysfunction are factors that drive the onset and persistence of Kaposi sarcoma (KS) in people with (PWH) and without HIV. …”
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AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

“…Background & Aims: Tumor-infiltrating lymphocytes (TILs), particularly CD8+ TILs, are key prognostic markers in many cancers. …”
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Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel F-Folate Radiotracer by Adrienne Müller, Katharina Beck, Zoran Rancic, Cristina Müller, Cindy R. Fischer, Thomas Betzel, Philipp A. Kaufmann, Roger Schibli, Stefanie D. Kramer, Simon M. Ametamey

“…Human endarterectomized specimens were used to measure gene expression levels of FR-β and CD68. Increased FR-β and CD68 levels were found in atherosclerotic plaques compared to normal artery walls by quantitative real-time polymerase chain reaction. …”
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A two-strain HIV-1 mathematical model to assess the effects of chemotherapy on disease parameters by Tinevimbo Shiri, Winston Garira, Senelani D. Musekwa

“…Model calculations show that there is a common pattern for CD4+ T cell count increase. There is a drastic increase of CD4+ T cells during the first few weeks of treatment, followed by a gradual increase, and these increases are strictly by clonal expansion of preexisting CD4+ T cells. …”
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