低浓度雷公藤甲素联合伊达比星诱导急性髓系白血病 干细胞凋亡及其机制

“…【方法】 应用流式细胞仪分选KG1a细胞中具有AML干细胞特性的CD34+CD38-亚群;对分选的CD34+CD38-KG-1α细胞进行免疫表型和细胞周期的测定;流式细胞术检测IC20浓度的雷公藤甲素?…”
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Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention by Fuli Fan, Shubei Liu, Bin Wang, Xiaojian Song, Wei Wang

“…Both transcriptome analyses and CyTOF-based immune phenotyping confirmed that AMB had increased levels of TBX21 (T-bet), ITGAX (CD11c), CD19, CD20 and CXCR3 (P < 0.05), and it had decreased expressions of CD27, CD38, CXCR4, CXCR5 and CD62L (P < 0.05). …”
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Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients by Francesco Giudici, Tiziana Cavalli, Cristina Luceri, Edda Russo, Daniela Zambonin, Stefano Scaringi, Ferdinando Ficari, Marilena Fazi, Amedeo Amedei, Francesco Tonelli, Cecilia Malentacchi

“…The study is aimed at analyzing, in a group of CD patients undergoing surgery, the relationship between CARD15/NOD2 polymorphisms and the clinical CD behavior after a long-term follow-up, in order to identify potential clinical biomarkers of prognosis. …”
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Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli by Yunjia Ren, Li Hua, Xiuping Meng, Yue Xiao, Xu Hao, Sheng Guo, Peiyan Zhao, Luowei Wang, Boqi Dong, Yongli Yu, Liying Wang

“…After E. coli infection, sTLR9 expression on CD11b+ and CD11b− PMNs and macrophages in the PLCs were increased at early stage and deceased at late stage; IL-17 expression was also increased in CD11b+ PMNs, CD11b− PMNs, macrophages, and CD3+ T cells. …”
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T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates by Joanna M. Schaenman, MD, PhD, Harry Pickering, PhD, Elaine F. Reed, PhD, Maura Rossetti, PhD, Benjamin Seligman, MD, S. Samuel Weigt, MD, Michael Shino, MD, David Sayah, MD, PhD, John Belperio, MD, Ashley Hu, MD, Ashley Prosper, MD, Kathleen Ruchalski, MD, Abbas Ardehali, MD, Reshma Biniwale, MD

“…Hospital readmission was associated with lower frequency of naïve CD4 (p = 0.004) and CD8 T cells (p = 0.026). Senescent CD4 (KLRG1+/CD28−) and CD8 T cells were also associated with readmission (p = 0.014 and p = 0.013, respectively), and senescent CD4 T cells were predictive of total hospital time (p = 0.003). …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…Flow cytometry was used to detect splenic CD4+CD25+FOXP3+ Tregs. Using magnetic beads to extract CD4+ T cells from mice spleen, the effects of A. fumigatus conidia or TLR2 inhibitor (C29) to differentiate CD4+ T cells in vitro were tested. …”
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The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model by Changjing Xu, Junlong Zhu, Kun Tu, Hui Tang, Xinxin Zhou, Qiuyu Li, Kun Chen, Xuping Yang, Yilan Huang

“…Patients were divided into the CD and the N-CD groups. The occurrence of CD was designated as the dependent variable. …”
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Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study by Alex Bottle, Sonia Saxena, Richard C G Pollok, Jonathan Blackwell, Irene Petersen, Hanna Creese, Nishani Jayasooriya, Richard CG Pollok

“…We used multivariable Cox regression to examine the association of primary care consultation frequency (n=1, 2, &gt;2), annual consultation intensity, hospitalisations for gastrointestinal symptoms, and time to diagnosis with a range of key clinical outcomes following diagnosis.Results We identified 2645 incident IBD cases (CD: 782; UC: 1863). For CD, &gt;2 consultations were associated with intestinal surgery (adjusted HR (aHR)=2.22, 95% CI 1.45 to 3.39) and subsequent CD-related hospitalisation (aHR=1.80, 95% CI 1.29 to 2.50). …”
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Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain by XIANG Hongchun, ZHANG Hong, LI Jing, LONG Man, LI Man, CAI Guowei

“…There were a small number of inflammatory cells in the control group, the number of inflammatory cells in the aggregating and infiltrating state increased in the model group, and there were fewer inflammatory cells in the EA group. (3) The percentage of MCP-1 and CD68 immunopositive areas in DRG tissues: compared with the control group, the percentage of MCP-1 and CD68 immunopositive areas in DRG tissues in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the percentage of MCP-1 and CD68 immunopositive areas in DRG tissues in the EA group decreased significantly (<italic>P</italic>&lt;0.05). (4) The protein expression level of MCP-1, CD68, IL-1β and iNOS in DRG tissues: compared with the control group, the protein expression level of MCP-1, CD68, IL-1β and iNOS in DRG tissues in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the relative protein expressions of MCP-1, CD68, IL-1β and iNOS in the DRG tissues in the EA group decreased significantly (<italic>P</italic>&lt;0.05). (5) Ultrastructure of macrophages in DRG tissues: the shape of macrophages in DRG tissues in the control group was nearly round, with round and blunt processes; the shape of macrophages in DRG tissue in the model group was flat, cells with pseudopodia, and the cell bodies were larger than those in the control group; the shape of macrophages in DRG tissues in the EA group was nearly round, and the cell bodies were larger than those in the control group.ConclusionEA at bilateral Zusanli acupoint (ST 36) can relieve neuropathic pain induced by paclitaxel in mice, and its mechanism may be that EA plays an analgesic role by down-regulating the expression of MCP-1 in DRG, inhibiting the infiltration of macrophages in DRG tissue, and reducing the release of IL-1β, iNOS and CD68 inflammatory factors in DRG tissue.…”
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Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease by Yuan Zhang, Cuiping Jia, Manli Guo, Qian Chen, Ying Wen, Ting Wang, Yinyin Xie, Xuejiao Fan, Jingwen Gao, Timur O. Yarovinsky, Renjing Liu, Zhiyong Jiang, Mengmeng Wang, Jin Zhou, Di Che, Lanyan Fu, Richard Edelson, Xiaoqiong Gu, John Hwa, Wai Ho Tang

“…Monocyte‐activated platelets initiate transforming growth factor (TGF)β1 release, which results in nuclear localization of nuclear factor kappaB in monocytes, therefore, driving the phenotypic conversion of classical monocytes (CD14+CD16−) into proinflammatory monocytes (CD14+CD16+). …”
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The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…Serum analysis revealed that TTO lowered levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglycerides(TG), CD3 positive CD4 positive T cells(CD3+CD4+), CD4 positive to CD8 positive Rratio(CD4+/CD8+), and alkaline phosphatase(AKP), while increasing albumin(ALB), globulin(GLO), immunoglobulin A(IgA), and immunoglobulin G(IgG) levels (P < 0.05). …”
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The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease by Khalid A. Abdelhalim, Ataç Uzel, Nalan Gülşen Ünal

“…Inflammatory bowel disease (IBD) is a term that describes Crohn’s disease (CD) and ulcerative colitis (UC), and these two conditions are characterised by chronic inflammation of the gastrointestinal tract. …”
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Photocatalytic Activity of Nanosized Cadmium Sulfides Synthesized by Complex Compound Thermolysis by Yingchun Yu, Youxian Ding, Shengli Zuo, Jianjun Liu

“…The nanosized cadmium sulfides (CdSs) containing different phase structures were synthesized via the complex compound thermolysis method using different molar ratio of thiourea to acetate cadmium (S/Cd) and characterized by XRD, TEM, UV-Vis, and IR spectra. …”
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Hypopigmented Mycosis Fungoides in an 11-Year-Old Palestinian Boy by Duha Rabi, Balqis Shawer, Ahmad Rabee, Mohammad Qudaimat, Mohammad Milhem, Izzeddin Bakri

“…Immunohistochemical staining was positive for CD3 and CD7 (partial) and a mixture of CD4 and CD8 positive cells. …”
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A Case of Histiocytic Sarcoma Arising from Mycosis Fungoides by Ethan A. Burns, Cesar Gentille, Saro Kasparian, Sai Ravi Pingali

“…Histiocytic sarcoma (HS) is an uncommon malignant neoplasm arising from mature histiocytes and most commonly characterized by the immunophenotypic expression of CD68, CD163, or lysozyme. Although rare, HS arising as a second primary malignancy following hematolymphoid neoplasms has been reported. …”
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Supramolecular Self-Assembled Nanospheres for Enzyme Encapsulation Based on Cyclodextrin by Zhenqiang Dong, Lili Wu, Dongdong Ma

“…Based on the cyclodextrin (CD) and guest molecules inclusion, a novel rigid-flexible polymeric nanosphere was prepared by supramolecular self-assemble. …”
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The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells by Andrew W. Taylor, Darren J. Lee

“…Previous characterizations of the α-MSH-induced Treg cells showed that the cells are CD4+ T cells expressing the same levels of CD25 as effector T cells. …”
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Simultaneous Diagnosis of Acute Crohn’s Disease and Endometriosis in a Patient Affects HIV by S. Casiraghi, P. Baggi, P. Lanza, A. Bozzola, A. Vinco, V. Villanacci, F. Castelli, M. Ronconi

“…These patients were more likely to have stricturing CD but endometriosis does not seem to impact the natural history of CD.…”
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Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy by Marzia Caproni, Veronica Bonciolini, Antonietta D'Errico, Emiliano Antiga, Paolo Fabbri

“…The knowledge about pathogenic, epidemiological, clinical, and diagnostic aspects of CD is increasing in recent years as well as those about DH, but some aspects still remain to be defined, in particular the possible pathogenetic mechanisms involved in the association between both CD and DH and CD and other immunological skin diseases. …”
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紫外线与氯化镉的急性、亚急性联合作用对动物免疫功能的影响

“…本文观察了长、短波紫外线（UVA、UVC）与氯化镉（CdCl2）的急性、亚急性联合作用对大、小鼠免疫功能的影响。小鼠急性实验结果显示:22.3和55.9J/cm2的UVA照射能增强小鼠的免疫力;223.56J/cm2的UVC与CdCl2（15mg/kg）共存时有协同作用。…”
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