The Application of Magnetic-Controlled Capsule Gastroscopy in Patients Refusing C-EGD: A Single-Center 5-Year Observational Study by Lihan Zhou, Sijia Wang, Jian Li, Jie Zhong, Ling Zhang, Ruizhe Shen, Bielike Kouken, Chunhua Zhou, Qi Wang, Yuting Qian, Duowu Zou, Ye Chu

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Cochlear Implant Programming: A Global Survey on the State of the Art by Bart Vaerenberg, Cas Smits, Geert De Ceulaer, Elie Zir, Sally Harman, N. Jaspers, Y. Tam, Margaret Dillon, Thomas Wesarg, D. Martin-Bonniot, L. Gärtner, Sebastian Cozma, Julie Kosaner, Sandra Prentiss, P. Sasidharan, Jeroen J. Briaire, Jane Bradley, J. Debruyne, R. Hollow, Rajesh Patadia, Lucas Mens, K. Veekmans, R. Greisiger, E. Harboun-Cohen, Stéphanie Borel, Dayse Tavora-Vieira, Patrizia Mancini, Helen Cullington, Amy Han-Chi Ng, Adam Walkowiak, William H. Shapiro, Paul J. Govaerts

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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Among the adjusted covariates, CD4 cell count<50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. …”
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Disparities in the uptake of HPV-related cancer prevention strategies among women by HIV status in Puerto Rico by Marievelisse Soto-Salgado, Melisa Ramos-Sepúlveda, Jeslie M. Ramos-Cartagena, Maribel Tirado-Gómez, Humberto M. Guiot, Cristina Muñoz-Masso, Lorena González-Sepúlveda, Ana Patricia Ortiz

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-Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD

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Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment by V.P. Erichev, S.Yu. Petrov, A.V. Volzhanin, D.M. Safonova, T.V. Yaremenko, S.A. Kazaryan

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Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care by Joosup Kim, Dominique A Cadilhac, Karen Smith, Ramesh Sahathevan, Stephen Bernard, Dion Stub, Voltaire Nadurata, Ernesto Oqueli, Thomas Kraemer, Chris F Bladin, Kathleen L Bagot, Michelle Vu, Grant Hocking, Tessa Coupland, Debra Pearce, Diane Badcock, Marc Budge, Wayne Pearce, Howard Hall, Ben Kelly, Angie Spencer, Pauline Chapman, Casey Hair

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Oral Cyclophosphamide for Patients With Metastatic Castration-Resistant Prostate Cancer in a Scenario of Limited Health Care Resources by Diana del Cisne Pineda, Gabriel Berlingieri Polho, Yumi Ricucci Shinkado, Gustavo Alves Contado, Nathalia de Souza Crusoe, Vivian Naomi Horita, Joao Carlos Resende, Jamile Almeida Silva, Guilherme Fialho de Freitas, David Queiroz Muniz, Caio V. Suartz, Leopoldo Alves Ribeiro-Filho, Paulo M. Hoff, José Mauricio Mota

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BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats by Ying Wang, Guang Li, Guofeng Li, Yutao Pan, Zhongmin Liu

“…The expressions of KRT14, α‐SMA, CD31 and PCNA in rat trauma tissues were analyzed by immunofluorescence staining. …”
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Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function by Emily G. Knox, Paula Sánchez-Díaz, Colin Buttimer, Sarah-Jane Leigh, Klara Vlckova, Colin Hill, Elaine Kennedy, Jonathan O’Regan, Seamus McSweeney, David Goulding, Maria Rodriguez Aburto, Caitriona M. O’Driscoll, John F. Cryan, Eoin Gunnigle, Gerard Clarke

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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

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Neovascular glaucoma as a complication of proton therapy for uveal melanoma by I.E. Panova, E.M. Svistunova, N.A. Vorobyov, E.V. Samkovich, N.I. Martynova, A.A. Bykhovsky

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Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions by Irma Saulle, Irma Saulle, Fiona Limanaqi, Micaela Garziano, Micaela Garziano, Maria Luisa Murno, Valentina Artusa, Valentina Artusa, Sergio Strizzi, Matteo Giovarelli, Carsten Schulte, Jacopo Aiello, Mario Clerici, Mario Clerici, Claudia Vanetti, Mara Biasin

“…In these cells following 3 h or 24 h rhERAP stimulation by Western Blot, RT-qPCR, Elisa, Confocal microscopy, transwell migration assay, Oxygraphy and Flow Cytometry we assessed: i) rhERAP internalization; ii) activation; iii) migration; iv) oxygen consumption rate; v) reactive oxygen species (ROS) accumulation; granule release; vi) phagocytosis; and vii) autophagy.ResultsWe observed that following stimulation rhERAPs: i) were internalized by neutrophils; ii) triggered their activation as witnessed by increased percentage of MAC-1+CD66b+ expressing neutrophils, cytokine expression/release (IL-1β, IL-8, CCL2, TNFα, IFNγ, MIP-1β) and granule enzyme secretion (myeloperoxidase, Elastase); iii) increased neutrophil migration capacity; iv) increased autophagy and phagocytosis activity; v) reduced ROS accumulation and did not influence oxygen consumption rate.ConclusionOur study provides novel insights into the biological role of ERAPs, and indicates that extracellular ERAPs, contribute to shaping neutrophil homeostasis by promoting survival and tolerance in response to stress-related inflammation. …”
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Three different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study by Safaa A. Hussein, Gharib M. Taha, F. A. Adam, Marwa A. Moghazy

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بررسی ویژگی های فتوسنتزی، تبادلات گازی، عناصر و ترکیبات برگ ارقام ماستئوئیدس، مانزانیلا، جلت و ماری زیتون... by مهدی شجاعی, منصور غلامی

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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

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Physicochemical Properties and Bioreactivity of Sub‐10 μm Geogenic Particles: Comparison of Volcanic Ash and Desert Dust by Ines Tomašek, Julia Eychenne, David E. Damby, Adrian J. Hornby, Manolis N. Romanias, Severine Moune, Gaëlle Uzu, Federica Schiavi, Maeva Dole, Emmanuel Gardès, Mickael Laumonier, Clara Gorce, Régine Minet‐Quinard, Julie Durif, Corinne Belville, Ousmane Traoré, Loïc Blanchon, Vincent Sapin

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HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…Echoing the above findings, in vivo, HDAC and MEK inhibitors significantly improved PD-1 blockade efficacy, accompanied by increased CD8+ T-cell infiltration.Conclusions Our findings indicate that combining HDAC inhibitor, MEK inhibitor, and PD-1 blockade is a potential strategy for treating BRAFV600E-mutant MSS CRC, warranting further investigation in clinical settings.…”
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Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…By employing various machine learning algorithms, we pinpointed eight pivotal genes linked to PCD, specifically FLT3, SORL1, CD8A, BCL2L1, COL13A1, MPG, DYRK2 and CAMK2B. Following this, we established a Programmed Cell Death Index (PCDI) utilizing the aforementioned genes and amalgamated it with pertinent clinical characteristics to formulate a predictive nomogram model for prognosis. …”
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Blood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution by Stéphane Rodriguez, Stéphane Rodriguez, Laura Couloume, Juliette Ferrant, Juliette Ferrant, Nicolas Vince, Marion Mandon, Marion Mandon, Rachel Jean, Rachel Jean, Celine Monvoisin, Simon Leonard, Simon Le Gallou, Simon Le Gallou, Nayane S. B. Silva, Nayane S. B. Silva, Sonia Bourguiba-Hachemi, David Laplaud, David Laplaud, Alexandra Garcia, Romain Casey, Romain Casey, Romain Casey, Romain Casey, Helene Zephir, Anne Kerbrat, Gilles Edan, Emmanuelle Lepage, Eric Thouvenot, Eric Thouvenot, Aurelie Ruet, Aurelie Ruet, Guillaume Mathey, Guillaume Mathey, Pierre-Antoine Gourraud, Pierre-Antoine Gourraud, Karin Tarte, Karin Tarte, Celine Delaloy, Patricia Amé, Patricia Amé, Mikael Roussel, Mikael Roussel, Laure Michel, Laure Michel, Laure Michel

“…This monocytic population, detected in both the CSF and blood, was characterized by CD206, CD209, CCR5 and CCR2 expression, and was found to be more frequent in MS patients carrying the HLA-DRB1*15:01 allele. …”
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