Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Indeed, without affecting the global number of (CD45+) immune cells, drastic reductions of monocytic/granulocytic myeloid-derived suppressor cells (MDSC) and regulatory T lymphocytes, a higher M1/M2 ratio of macrophages as well as an increased activation of both DC and pDC were continually observed following HMGB1 inhibition. …”
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Elevated D-dimer on admission may predict poor prognosis in childhood influenza associated encephalopathy by Huizhen Wang, Lingkong Zeng, Xingfeng Cheng, Hui Li, Hong Zhang, Yuanmei Shi, Yong Zhang, Changjian Li

“…In the univariate analysis, the poor prognosis group compared with the clinically cured group showed a significant increase in the number of days of hospitalization (3.0 vs. 9.5 days, P < 0.001), high-sensitivity C-reactive protein (6.80 vs. 1.88 mg/L, P = 0.003), interleukin-6 (20.26 vs. 8.24 pg/mL, P = 0.001), interleukin-10 (11.75 vs. 4.72 pg/mL, P = 0.003), alanine aminotransferase (104.0 vs. 20.0 U/L, P = 0.011), aspartate azelotransferase (186.5 vs. 37.0 U/L, P = 0.003), serum albumin (37.99 vs. 40.76 g/L, P = 0.042), prothrombin time (13.2 vs. 11.4 s, P = 0.017), D-dimer (4.34 vs. 0.44 mg/L FEU, P < 0.001), peripheral blood CD19 B-cell count (35.11 vs. 32.75 cells/µL, P = 0.018), and cerebrospinal fluid chloride (126.82 vs. 125.50 mmol/L, P = 0.027) were statistically different in the above 11 indicators. …”
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慢病毒介导的Clusterin基因沉默抑制肾癌786-O细胞增殖并促进细胞凋亡

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Cloning and sequencing of VP19-encoding gene of white spot syndrome virus from Situbondo’s isolate by Sahrul Alim, Dinamella Wahjuningrum, Muhamad Ali

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睡眠剥夺对正常成年人前庭功能影响的初步研究 by 吴诗欣, 黎志成, 张姝琪, 李凌伟, 吴慧青, 曾祥丽

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Évaluation de la prescription et de l’utilisation des benzodiazépines dans la ville de Sidi Bel-Abbès by Derouicha Matmour, Mounia Medjeber, Yassine Merad

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lncRNA-SNHG14 Plays a Role in Acute Lung Injury Induced by Lipopolysaccharide through Regulating Autophagy via miR-223-3p/Foxo3a by Jun Hong, Shijing Mo, Fangxiao Gong, Zongbin Lin, Hanhui Cai, Ziqiang Shao, Xianghong Yang, Renhua Sun, Qiangnu Zhang, Jingquan Liu

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The Financial Implications of Pancreatic Surgery: The Hospital Is the Big Winner, Not the Surgeon! by Nitzan Zohar, MD, Avinoam Nevler, MD, Sean P. Maher, Matthew C. Rosenthal, Florence Williams, Wilbur B. Bowne, MD, FACS, Charles J. Yeo, MD, FACS, Harish Lavu, MD, FACS

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CAMELS-IND: hydrometeorological time series and catchment attributes for 228 catchments in Peninsular India by N. K. Mangukiya, K. B. Kumar, P. Dey, S. Sharma, V. Bejagam, P. P. Mujumdar, P. P. Mujumdar, A. Sharma, A. Sharma

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مروری بر درمان ترکیبی با دوز ثابت برای پیشگیری ثانویه از حوادث نامطلوب قلبی- عروقی و نتایج اولیه‌ی کارآزمایی بالینی تصادفی شده‌ی PersianPolypill... by معصومه صادقی, حمیدرضا روح افزا, علیرضا ناطقی, دکتر نضال صراف زادگان, مرجان منصوریان, جمشید نجفیان, فاطمه بستان, شروین غفاری حسینی

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Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma by Thomas Kapapa, Vanida Wernheimer, Andrea Hoffmann, Tamara Merz, Fabia Zink, Eva-Maria Wolfschmitt, Oscar McCook, Josef Vogt, Martin Wepler, David Alexander Christian Messerer, Claire Hartmann, Angelika Scheuerle, René Mathieu, Simon Mayer, Michael Gröger, Nicole Denoix, Enrico Clazia, Peter Radermacher, Stefan Röhrer, Thomas Datzmann

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improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

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Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus by Dian-dian Zhao, Pei-lin Jiao, Jing-jia Yu, Xiao-jing Wang, Lin Zhao, Yan Xuan, Li-hao Sun, Bei Tao, Wei-qing Wang, Guang Ning, Jian-min Liu, Hong-yan Zhao

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A Predictive Model for Super-Response to Cardiac Resynchronization Therapy: The QQ-LAE Score by Xi Liu, Yiran Hu, Wei Hua, Shengwen Yang, Min Gu, Hong-Xia Niu, Li-Gang Ding, Jing Wang, Shu Zhang

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Evaluasi Sistem Informasi Menggunakan Technology Acceptance Model dengan Penambahan Variabel Eksternal by Ria Andriani, Arief Setyanto, Asro Nasiri

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Evaluation of Prayer Windows with Inscriptions Located Around the Mausoleum of Eyup Sultan by Saliha Tanık, Aliye Öten

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Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma by I. A. Goncharova, A. A. Zarubin, N. P. Babushkina, I. A. Koroleva, M. S. Nazarenko

“…Among the genes of fibrogenesis or DNA repair, cg14143055 (ADAMDEC1) is located in the binding region of the HOX gene family transcription factors (TFs), while cg05921699 (CD79A), cg06196379 (TREM1) and cg10990993 (MLH1) are located in the binding region of the ZNF protein family transcription factor (TF). …”
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Consonant Error Patterns in Children with Functional Dysarthria and Dysarthria with Language Retardation by Zhenping LIN, Zhuoming CHEN, Yuchang LI, Na LI, Zhimei LIU, Xian XIE, Dan LI

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اثر زمان برداشت، نیتروژن و تراکم کاشت بر عملکرد و برخی صفات فیزیولوژیکی گیاه دارویی پونه معطر (.Mentha pulegium L)... by باب اله فرجی, امیر صحرارو, یوسف حمیداوغلی, جمالعلی الفتی

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Statistically Coherent Calibration of X-Ray Fluorescence Spectrometry for Major Elements in Rocks and Minerals by Surendra P. Verma, Sanjeet K. Verma, M. Abdelaly Rivera-Gómez, Darío Torres-Sánchez, Lorena Díaz-González, Alejandra Amezcua-Valdez, Beatriz Adriana Rivera-Escoto, Mauricio Rosales-Rivera, John S. Armstrong-Altrin, Héctor López-Loera, Fernando Velasco-Tapia, Kailasa Pandarinath

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