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    Early-Stage Luminal B-like Breast Cancer Exhibits a More Immunosuppressive Tumor Microenvironment than Luminal A-like Breast Cancer by Tânia Moura, Olga Caramelo, Isabel Silva, Sandra Silva, Manuela Gonçalo, Maria Antónia Portilha, João N. Moreira, Ana M. Gil, Paula Laranjeira, Artur Paiva

    Published 2025-01-01
    “…Results: The luminal B-like tumor samples exhibited increased infiltration of CD4<sup>+</sup> cells, regulatory T cells (Tregs), and Th17 cells and decreased levels of NK cells, γδ T cells, Th1 cells, and follicular T cells, which is indicative of a more immunosuppressive tumor microenvironment. …”
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    Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population by Iryna Kril, Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak

    Published 2025-01-01
    “…These molecules present antigenic peptides to CD8+ T lymphocytes and natural killer cells. HLA-I molecules bind their peptide cargo (8–10 amino acids long) in the endoplasmic reticulum. …”
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    Utilization of Phosphogypsum and Sediment in Subgrade Material for Pavement Construction by Dragana Tomašević Pilipović, Nataša Slijepčević, Dunja Rađenović Veselić, Miloš Šešlija, Vesna Bulatović, Nataša Duduković

    Published 2025-01-01
    “…This study investigates the feasibility of incorporating phosphogypsum (PG) and contaminated sediment into subgrade materials, focusing on their physico-chemical and physico-mechanical properties. (2) Methods: The physico-chemical and physico-mechanical properties, performance, and mechanisms of solidified sediment with phosphogypsum (3% and 5% of phosphogypsum in mixture) were studied using long-term leaching tests (ANS 16.1), uniaxial compressive strength (UCS), California Bearing Ratio (CBR), X-ray fluorescence (XRF), and thermogravimetric analysis (TGA). (3) Results: Based on the pseudo-total metal content (Cr, Ni, Cu, Zn, As, Cd, Pb), the sediment is classified as third- and fourth-class, indicating it is polluted and requires treatment before disposal in the environment. …”
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    Maternal-fetal cytokine profiles in acute SARS-CoV-2 “breakthrough” infection after COVID-19 vaccination by Claire H. Packer, Olyvia Jasset, Nikolina Hanniford, Sara Brigida, Stepan Demidkin, Roy H. Perlis, Roy H. Perlis, Andrea G. Edlow, Andrea G. Edlow, Lydia L. Shook, Lydia L. Shook

    Published 2025-01-01
    “…Significantly higher maternal levels of TNFα and CD62P were observed in vaccinated individuals with SARS-CoV-2 BTI compared with unvaccinated individuals with infection (p&lt;0.05). …”
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    Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

    Published 2025-02-01
    “…After filtering using methods such as phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking, six potentially druggable genes (BAK1, AMFR, LAMP3, STK17B, ACP5, and CD9) and six drugs (beclomethasone, propyl pyrazole triol, momelotinib, monoisoamyl-2,3-dimercaptosuccinate, pterostilbene, and naftidrofuryl) that may affect ARHL outcomes were finally identified. …”
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    MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

    Published 2025-02-01
    “…Moreover, significantly greater CD31 expression, less DLAT accumulation, more mitochondria, and fewer mitochondrial abnormalities were observed in the CPOMT2A+ group than in the CPO group, accompanied by significantly improved cerebral blood perfusion and cognitive function. …”
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