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Single-cell transcriptome atlas of peripheral immune features to Omicron breakthrough infection under booster vaccination strategies
Published 2025-01-01“…IntroductionThe high percentage of Omicron breakthrough infection in vaccinees is an emerging problem, of which we have a limited understanding of the phenomenon.MethodsWe performed single-cell transcriptome coupled with T-cell/B-cell receptor (TCR/BCR) sequencing in 15 peripheral blood mononuclear cell (PBMC) samples from Omicron infection and naïve with booster vaccination.ResultsWe found that after breakthrough infection, multiple cell clusters showed activation of the type I IFN pathway and widespread expression of Interferon-stimulated genes (ISGs); T and B lymphocytes exhibited antiviral and proinflammatory-related differentiation features with pseudo-time trajectories; and large TCR clonal expansions were concentrated in effector CD8 T cells, and clonal expansions of BCRs showed a preference for IGHV3. …”
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23903
Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome
Published 2025-01-01“…Finally, depleting monocytes through the usage of a CD14 neutralizing antibody or blocking monocyte chemotaxis via inhibition of CCL2 notably mitigates kidney injury and dysfunction caused by lipopolysaccharide (LPS)/Stx2 treatment. …”
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23904
A Path to High-Value Gastric Cancer Surgery Care Delivery
Published 2024-06-01Get full text
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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease
Published 2025-02-01“…Lymphopenia, more apparent among natural killer (NK) cells, CD8+ T-cells, and B-cells, can contribute to disease severity and may reflect direct cytopathic effects of SARS-CoV-2 or end-organ sequestration. …”
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Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation
Published 2025-01-01“…In addition, hub genes exhibited significant correlation with Eosinophils, NK cells resting, Dendritic cells resting, NK cells activated and T cells CD4 memory activated. We verified the expression of SLC7A11, PSAT1 and ASNS was higher than that in normal tissues using RT-qPCR and western blot in mouse models of heart transplantation with I/R, companied by ferroptosis aggravated is involved. …”
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Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma
Published 2025-01-01“…RAPA-201 drug products (DPs) were: polyclonal; enriched for TCM cells; reduced for immune checkpoint expression, including PD1, CD73, and LAIR1; and preferentially secreted Th1 cytokines. …”
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IDH-mutant gliomas in children and adolescents - from biology to clinical trials
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Transforming 5G Mega-Constellation Communications: A Self-Organized Network Architecture Perspective
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer
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Espacios verdes espontáneos. Análisis de factores que promueven su surgimiento
Published 2023-11-01Get full text
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