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    Exploring lipidome mediated inflammatory pathways in acute pancreatitis using mendelian randomization by Wenbin Liu, Song Yang, Yuhan Li, Dava Tenzing, Ruizi Shi, Yang Jiang, Hao Deng, Enqiang Mao, Ying Chen, Yihui Wang

    Published 2025-01-01
    “…Additionally, five inflammatory factors (CD5, IL-13, MMP-1, STAMBP, TNFRSF9) showed significant potential causal relationship with AP. …”
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    DHAOx方案治疗复发和难治性非霍奇金淋巴瘤的研究

    Published 2010-01-01
    “…【目的】 探讨 DHAOx方案(地塞米松65380;大剂量阿糖胞苷65380;奥沙利铂)治疗复发和难治性非霍奇金淋巴瘤(NHL)的近期疗效和不良反应65377; 【方法】 中山大学肿瘤防治中心近年采用DHAOx ± R方案(地塞米松 20 mg/d静脉滴注d1~4; 阿糖胞苷2 000 mg/m2 3 h静脉滴注,12 h重复一次 d2;奥沙利铂130 mg/m2 2 h静脉滴注d1;加或不加抗CD20单克隆抗体利妥昔单抗375 mg/m2,d0)治疗20例复发和难治性NHL患者,其中6例缓解后接受了自体外周血造血干细胞移植支持下的超大剂量化疗65377;客观疗效评定参照1998年美国和国际淋巴瘤专家组制定的 NHL疗效评价标准,分为完全缓解(CR),部分缓解(PR),稳定(SD)和疾病进展(PD);不良反应评价按照WHO不良反应评价标准分为0-Ⅳ度65377; 【结果】 20例患者共化疗47疗程,接受DHAOx方案13例(65%),DHAOx + R方案7例(35%),20例均可评价疗效,总有效率55% (11/20),完全缓解率(CR) 35% (7/20),既往接受过含铂类方案的患者再次接受DHAOx ± R方案亦有效65377;主要的不良反应为骨髓抑制,主要表现为中性粒细胞下降和血小板下降,Ⅲ ~ Ⅳ级的中性粒细胞下降占35%(16/47),其中粒细胞缺乏合并感染性发热占17 %(8/47);Ⅲ ~ Ⅳ级的血小板下降占20%(9/47);轻度的外周神经毒性占17%(8/47)65377;中位随访12个月(1 ~ 32个月),1年和2年生存率均为70.6%65377;【结论】 DHAOx治疗复发难治NHL有效率与传统DHAP方案(地塞米松65380;大剂量阿糖胞苷65380;顺铂)相似,不良反应可耐受,值得在更大宗病例中作进一步的研究65377;…”
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    Evaluation of Left Atrial Function in Patients with Paroxysmal Atrial Fibrillation Using Left Atrial Automatic Myocardial Functional Imaging Ultrasonography by Hailan Liu, Lili Chen, Yan Song, Yingying Xu, Chunquan Zhang

    Published 2023-01-01
    “…The LA emptying fraction (LAEF) was significantly decreased, and LA reservoir strain (S_R), LA conduit strain (S_CD), and LA contractile strain (S_CT) were significantly compromised (P < 0.05). …”
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