E3泛素-蛋白连接酶Parkin介导线粒体自噬参与荷瘤小鼠心肌损伤 by 邓世杰, 李兴会, 蔡卫斌

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Population Pharmacokinetics of Pegcetacoplan in Patients with Geographic Atrophy or Neovascular Age-related Macular Degeneration by Ryan L. Crass, PharmD, Komal Prem, MD, Francois Gauderault, PhD, Ramiro Ribeiro, MD, PhD, Caroline R. Baumal, MD, Brandon Smith, PhD, Daniel Epling, PhD, Sunny Chapel, PhD

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Keterkaitan Personal Growth Initiative dan Harapan dengan Adaptabilitas Karir pada Mahasiswa Vokasi by Hartawati Indah Pertiwi, Ridwan Budi Pramono

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Lineamientos para el uso de terapias pulpares en dientes primarios con pulpas no-vitales by Coll JA, Dhar V, Vargas K, et al., Grupo Trabajo Asociación Latinoamericana de Odontopediatría

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Diffusion Tensor Imaging Evaluation of Neural Network Development in Patients Undergoing Therapeutic Repetitive Transcranial Magnetic Stimulation following Stroke by Naoki Yamada, Ryo Ueda, Wataru Kakuda, Ryo Momosaki, Takahiro Kondo, Takuya Hada, Nobuyuki Sasaki, Takatoshi Hara, Atsushi Senoo, Masahiro Abo

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Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

“…In this study, we have developed classification sequence-structure-property relationships (SSPR) models for predicting the pathogenicity of amino acid substitutions (AAS) in 25 proteins associated with the most important and genetically studied PIDs and encoded genes: IL2RG, JAK3, RAG1, RAG2, ADA, DCLRE1C, CD40LG, WAS, ATM, STAT3, KMT2D, BTK, FOXP3, AIRE, FAS, ELANE, ITGB2, CYBB, G6PD, GATA2, STAT1, IFIH1, NLRP3, MEFV, and SERPING1.MethodsThe data on 4825 pathogenic and benign AASs in the selected proteins were extracted from ClinVar and gnomAD. …”
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Predicting cardiovascular outcomes in Chinese patients with type 2 diabetes by combining risk factor trajectories and machine learning algorithm: a cohort study by Qi Huang, Xiantong Zou, Zhouhui Lian, Xianghai Zhou, Xueyao Han, Yingying Luo, Shuohua Chen, Yanxiu Wang, Shouling Wu, Linong Ji

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A framework for quantifying the multisectoral burden of animal disease to support decision making by Sara Lysholm, Sara Lysholm, Gemma L. Chaters, Gemma L. Chaters, Carlotta Di Bari, Carlotta Di Bari, Ellen C. Hughes, Ellen C. Hughes, Ben Huntington, Ben Huntington, Jonathan Rushton, Jonathan Rushton, Lian Thomas, Lian Thomas

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Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers by Daehwan Kim, Heekyung Chung, Wen Liu, Kangjin Jeong, Tugba Y. Ozmen, Furkan Ozmen, Matthew J. Rames, Sangyub Kim, Xiao Guo, Nathan Jameson, Petrus R. de Jong, Steven Yea, Laurie Harford, Jiali Li, Cara A. Mathews, Deborah B. Doroshow, Vincent J. Charles, Doris Kim, Kimberlee Fischer, Ahmed A. Samatar, Adrian Jubb, Kevin D. Bunker, Kimberly Blackwell, Fiona Simpkins, Funda Meric-Bernstam, Gordon B. Mills, Olivier Harismendy, Jianhui Ma, Mark R. Lackner

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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Formation of abnormal blood vessels increases area of hypoxia which recruits suppressor cells, blocks tumor infiltration by CD8+ T lymphocytes, inhibits efficacy of chemoterapeutic drug and leads to cancer relapse. …”
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Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract by Lixia Ma, Yimeng Dou, Rui Liu, Teng Xu, Fan Yang, Peihao Zheng, Shaomei Feng, Yuelu Guo, Hui Shi, Fei Xue, Biping Deng, Xiaoyan Ke, Kai Hu

“…Methods During the period from May 2019 to August 2022, a total of 26 patients recurrent/refractory with recurrent/refractory B‐cell lymphoma involving the gastrointestinal tract enrolled. Pathology confirmed CD19 antigen expression in tumor tissues. The disease status of patients who failed multiple lines of therapy was progressive disease (PD). …”
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The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity by Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch

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The role of paternal support in breastfeeding outcomes: a meta-analytic review by Si-si Zhou, Jia Lu, An Qin, Yang Wang, Wei Gao, Hong Li, Lin Rao

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完全性雄激素不敏感综合征合并苗勒管残留临床特点的分析与探讨 by 邱珊娇, 许钰英, 张军, 陈德禄, 徐诚, 马华梅, 刘钧澄, 林少宾

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Public Benefit and Public Interest – Two Sides of the Same Coin? by Tina Sever

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Revealing viral hepatitis epidemiology in the Democratic Republic of Congo: insights from yellow fever surveillance reanalysis by Patrick Mukadi-Kakoni, Yannick Munyeku-Bazitama, Gracia Kashitu-Mujinga, Marguerite Manwana-Pemba, Niclette Zenga-Bibi, Patient Okitale-Talunda, Christelle Mbelu-Kabongo, Fleurette Domai-Mbuyakala, Elisabeth Pukuta-Simbu, Pierre Mutantu-Nsele, Yoshinao Kubo, Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Koya Ariyoshi, Jean-Jacques Muyembe-Tamfum

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In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney by Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, Yukiko Kamiya, Hiroyuki Asanuma, Shoichi Maruyama

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Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration by Junyi Zhu, Yijia Zhang, Yinuo Sun, Fangzheng Yu, Yang Lu, Qianqian Hu, Jiali Guo, Haijuan Zhang, Tianling Chen, Feifei Lian, Jian Wang, Xiaokun Li, Jian Xiao

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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

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The Economic Analysis of the Overlooked Recurrent Low Back Pain: Three Years Retrospective Observational Study by Szyszka J, Matuska J, Szyszka BG, Walkowiak D, Skorupska E

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