After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia by Mario Delia, Paola Carluccio, Anna Mestice, Roberta Frappampina, Francesco Albano, Giorgina Specchia, Pellegrino Musto

“…In particular, immune suppressive regulatory T cells (Tregs) may contribute to this defective antileukemic immune response, being recruited by bone marrow leukemic cells to evade immune surveillance. We evaluated Tregs (CD4+/CD45RA-/CD25high/CD127low), performing multiparametric flow cytometry on freshly collected bone marrow aspirate (BMA), in addition to the usual molecular and cytogenetic work-up in newly diagnosed AML patients to look for any correlation between Tregs and the overall response rate (ORR). …”
Get full text

Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…There was increased expression of CD8+ CD68+ M1 macrophage markers with upregulation of iNOS and co-expression of CD163+. …”
Get full text

USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…In vitro experiments demonstrated that USP25−/− CD4+ T lymphocytes had a higher proportion for Th17 cell differentiation and exhibited higher RORγt levels upon stimulation. …”
Get full text

Heavy Metal Ion Adsorption Properties of Methacrylamidocysteine-Containing Porous Poly(Hydroxyethyl Methacrylate) Chelating Beads by Adil Denizli, Bora Garipcan, Sibel Emir, Süleyman Patir, Ridvan Say

“…The maximum adsorption capacities of the p(HEMA–MAC) beads were 1058.2 mg/g for Cd II , 123.4 mg/g for As III , 199.6 mg/g for Cr III , 639.1 mg/g for Pb II and 1018.6 mg/g for Hg II . …”
Get full text

Soluble Markers of Antibody Secreting Cell Function as Predictors of Infection Risk in Rheumatoid Arthritis by Maria J. Gutierrez, Stephen V. Desiderio, Nae-Yuh Wang, Erika Darrah, Laura Cappelli, Gustavo Nino, Michelle Jones, Clifton O. Bingham

“…Using the Johns Hopkins Arthritis Cohort and Biorepository, we contrasted serum protein levels of soluble factors involved in B-cell activation (CD40, CD40L) and B-cell/ASC homing (CXCL10, CXCL11, and CXCL13) or survival (BAFF, APRIL, TACI, and BCMA) in 10 healthy subjects and 23 adult RA patients (aged 24-65 years). …”
Get full text

An analysis of heavy metals contamination and estimating the daily intakes of vegetables from Uganda by Keneth Iceland, Kasozi, Eric Oloya, Otim, Herbert Izo, Ninsiima, Gerald, Zirintunda, Andrew, Tamale, Justin, Ekou, Grace Henry, Musoke, Robert, Muyinda, Kevin, Matama, Regan, Mujinya, Henry, Matovu, Fred, Ssempijja, Ejike, Daniel Eze, Mauryn, Atino, Bede, Udechukwu, Ronald, Kayima, Patrick, Etiang, Emmanuel Tiyo, Ayikobua, Stellamaris, Kembabazi, Ibe Michael, Usman, Sheu Oluwadare, Sulaiman, Phyllis Candy, Natabo, Grace Nambatya, Kyeyune, Gaber El-Saber, Batiha, Ochan, Otim

“…Environmental contamination with elevated levels of copper (Cu), cobalt (Co), iron (Fe), zinc (Zn), lead (Pb), chromium (Cr 6þ), cadmium (Cd), and nickel (Ni)—all states of which are found in Uganda—raises health risk to the public. …”
Get full text

Administration of Rhodiola kirilowii Extracts during Mouse Pregnancy and Lactation Stimulates Innate but Not Adaptive Immunity of the Offspring by Sławomir Lewicki, Ewa Skopińska-Różewska, Aleksandra Brewczyńska, Robert Zdanowski

“…These changes correlated with decreased percentage of CD3+/CD4+ T-cells (RKW and RKW-A), decrease of CD8+ cells, and increase percentage of NK cells in RKW group. …”
Get full text

Trace Metal Content of Sediments Close to Mine Sites in the Andean Region by Cristina Yacoub, Agustí Pérez-Foguet, Nuria Miralles

“…Sediment concentrations of Al, As, Cd, Cu, Cr, Fe, Hg, Ni, Pb, Sb, Sn, and Zn were analyzed. …”
Get full text

Research on Trypanosoma cruzi and Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega by Eliângela de Castro Côbo, Thales Parenti Silveira, Adilha Misson Micheletti, Eduardo Crema, Sheila Jorge Adad

“…Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+).…”
Get full text

Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature by Vishwas Parekh, Thomas Winokur, Robert J. Cerfolio, Todd M. Stevens

“…The lesional cells expressed cytokeratin, calretinin, and nuclear WT1 but were negative for PAX8, TTF1, p53, chromogranin, CD31, and CD34, and Ki67 showed <2% proliferation rate, diagnostic of adenomatoid tumor. …”
Get full text

Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Maggie L. Diller, Ragini R. Kudchadkar, Keith A. Delman, David H. Lawson, Mandy L. Ford

“…IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage. …”
Get full text

Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy by Amandeep Singh, Nayere Zaeri, Immanuel K. Ho

“…We herein present the case of a 53-year-old female patient who developed celiac disease (CD) as a result of triple therapy (interferon, ribavirin, and boceprevir) for chronic HCV. …”
Get full text

Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study by Ennio Bramanti, Marco Cicciù, Giada Matacena, Stefano Costa, Giuseppe Magazzù

“…Patients involved on coeliac disease (CD) have atypical symptoms and often remain undiagnosed. …”
Get full text

Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C by Xi-yu Liu, Hong Li

“…Reduced global H3 lysine 9 methylation was observed in LADA patients’ CD4+ T lymphocytes, compared to healthy controls (P < 0.05). …”
Get full text

An analysis of trace element by atomic absorption in samples of human milk collected in Amapá’s Bank of Milk by Danilo Monteiro Monteiro, Roberto Bezerra Messias

“…For example, in a milk sample a content of 1 ppm Cd was found, thereby being an average value of contamination. …”
Get full text

A Diversified Spectrometric and Molecular Docking Technique to Biophysical Study of Interaction between Bovine Serum Albumin and Sodium Salt of Risedronic Acid, a Bisphosphonate fo... by M. Manjushree, Hosakere D. Revanasiddappa

“…The conformational and secondary structural changes observed for BSA from CD spectra and by curve fitting procedure were applied to Fourier self-deconvolution in FT-IR spectra. …”
Get full text

Analysis of heavy metal concentration from sugar mill and its impact on groundwater “a case study of shaheed benazirabad (SBA) Sindh Pakistan” by Lashari Saima, Muhammad Fuad, Warsito Budi

“…After analyzing the collected samples of wastewater, Pb, Cd, As, and Ni concentrations were found in excess than the recommended limits set by the PAKEPA. …”
Get full text

An Assessment of Heavy Metals in <i>Synodontis Clarias</i> (Linnaeus, 1766) from Ikpoba Reservoir, Benin City, Nigeria by OM Wangboje, JAO Oronsaye

“…This study determined the concentrations of Cd, Mn, Cu, Pb, Zn and Cr in Synodontis clarias (Linnaeus, 1766) and water from Ikpoba Reservoir, Benin City, Nigeria, in order to ascertain the magnitude of impact by these heavy metals on the resources of the investigated ecosystem. …”
Get full text

ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation by Sheng-Wen Chen, Ying Chu, Chien-Hsin Chu, Xuan-Dieu Thi Pham, Hang Pong Ng, Chin-Lin Guo, Pei-Lin Cheng

“…Intraspinal adeno-associated virus (AAV)/Olig001-mediated expression of the self-antigen NDUFA1p ameliorates EAE and expands NDUFA1p-recognizing CD103+CD8+CD122+ Treg cells. Thus, Ecm29/proteasome-controlled, neuroglia-derived self-antigens modulate CNS immune tolerance.…”
Get full text

Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study by Zheng Wang, Mengshu Pan, Jie Zhu, Changhong Liu

“…Among these immune cells, hepatocarcinogenesis had the greatest impact on CD4 on EM CD4 + and CD33 on Mo MDSC. Conclusions This study enhances our comprehension of the interaction between immune cells and HCC risk, furnishing novel avenues to explore the mechanisms of HCC.…”
Get full text